“…In particular, a careful analysis of such cases revealed that in this population, the hippocampal formation systematically displayed a moderate to severe involvement, whereas the neocortical areas were unaffected or showed very low densities of NFTs and SPs Arriagada et al, 1992a ;Berg et al, 1993;Bouras et al, 1993). This difference in regional lesion distribution distinguishes these elderly nondemented cases from the Alzheimer's disease population, in which neocortical areas are devastated (Pearson et al, 1985;Lewis et al, 1987;Hof et al, 1990aHof et al, ,b, 1992Bouras et al, 1992). Most of the recent clinicoanatomic analyses of brain aging have been based on relatively small patient samples consisting of selected cases (Crystal et al, 1988;Katzman et al, 1988;Hubbard et al, 1990;Morris et al, 1991;Price et al, 1991;Arriagada et al, 1992a,b;.…”