Selective Electrochemical Detection of Epinephrine Using Gold Nanoporous Film

Abstract

Epinephrine (EP) is one of the important catecholamine neurotransmitters that play an important role in the mammalian central nervous system. Therefore, it is necessary to determine the change of its concentrations. Nanoporous materials have wide applications that include catalysis, energy storages, environmental pollution control, wastewater treatment, and sensing applications. These unique properties could be attributable to their high surface area, a large pore volume, and uniform pore sizes. A gold nanoporous layer modified gold electrode was prepared and applied for the selective determination of epinephrine neurotransmitter at low concentration in the presence of several other substances including ascorbic acid (AA) and uric acid (UA). The constructed electrode was characterized using scanning electron microscopy and cyclic voltammetry. The resulting electrode showed a selective detection of epinephrine with the interferences of dopamine and uric acid over a wide linear range (from 50 μM to 1 mM). The coverage of gold nanoporous on the surface of gold electrode represents a promising electrochemical sensor with high selectivity and sensitivity.

Hierarchical C-N doped NiO with dual-head echinop flowers for ultrasensitive monitoring of epinephrine in human blood serum

“…To date, the materials used for electrode fabrication showed redox probes of EPI at high over potential due to the slow-moving of charges over electrode at traditional bare working electrodes (i.e., Au, Ag, Pt, glassy carbon, and graphite). Synthesis of highly reliable electrodes with fast response binding and high molecular diffusion along the entire active coverage surfaces is demanded to sensitive and selective detection of EPI, particularly in the presence of highly comparative species such as ascorbic acid (AA) and uric acid (UA) [12][13][14][15][16][17][18][19].…”

Electrochemical sensor for the detection of adrenaline at poly(crystal violet) modified electrode: optimization and voltammetric studies

“…The LOD and LDR obtained in this study are comparable with that of a wide range of sensors in literature ( Table 4 ). Specifically, the proposed sensor gave a lower LOD than some existing electrochemical AD sensors [ 45 , 46 ]. This implies that it could be accurately applied for AD detection at the micromolar level over a wide LDR.…”

Electrochemical Cell Chips Based on Functionalized Nanometals

“…Moreover, fabrication of porous Au film modified electrodes was reported to enhance the electrochemical conductivity and developing highly sensitive cell-based chip for rapid cancer detection (El-Said et al, 2010 ) electrochemical biosensors (Fouad and El-Said, 2016 ; Bollella et al, 2019 ; Jo and Shin, 2020 ). The unique electrochemical, optical, and biocompatible properties of the noble metals NPs besides their ability to form in several shapes with a larger surface area represented one of the best candidates to enhance the efficiency of electrochemical/spectrochemical-based biosensors.…”