Selective Electrochemical Determination of Paracetamol Using Nanostructured Film of Functionalized Thiadiazole Modified Electrode

Kalimuthu, Palraj; John, S. Abraham

doi:10.1002/elan.200900362

Cited by 20 publications

(9 citation statements)

References 31 publications

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“…Taking the above mentioned lacune and the high electroactivity of PCM into consideration, electrochemical analytical techniques for PCM determination has been 3 widely explored method due to simplicity, high sensitivity, low cost, easy operation and possibility to miniaturization [18][19][20][21]. Hence, considerable efforts have been devoted to modify the electrode for enhancing its voltammetric response and analytical performance [23][24][25][26][27][28][29][30][31][32][33][34][35][36]. Another problem commonly encountered at bare electrode is that they get poisoned by several species and decrease sensitivity and reproducibility.…”

Section: Introductionmentioning

confidence: 99%

MWCNT–CTAB modified glassy carbon electrode as a sensor for the determination of paracetamol

et al. 2015

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An electrochemical sensor for sensitive detection of paracetamol (PCM) was developed by constructing the glassy carbon electrode (GCE) modified with multiwalled carbon nanotubecetyltrimethyl ammonium bromide (MWCNT-CTAB). Modification improves the redox kinetics of PCM with increased current intensity. A similar modification at CTAB modified GCE did not result in an impressive charge transfer. Detection limit of PCM was determined from differential pulse voltammetric (DPV) study and found to be 4.82×10 −9 M with a linear dynamic range of 4.0×10 −7 M to 4.0×10 −6 M. The interference studies showed that the modified electrode exhibits excellent selectivity in the presence of large excess of interferents and response is fast, stable, reliable, resistant to biofouling and can be applied for the real sample analysis in medical, pharmaceutical and biotechnological sectors.Kinetic parameters were determined using electrochemical approaches. The practical analytical application of this electrode was demonstrated by measurement of PCM content in PYREMOL 650 tablet and real sample analysis.

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Section: Introductionmentioning

confidence: 99%

MWCNT–CTAB modified glassy carbon electrode as a sensor for the determination of paracetamol

et al. 2015

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“…Hence, the electrostatic interaction between -COOof MA and -N +. H -of the p-ATT is also possible [33] (Scheme 2). After four cycles, the oxidation current of MA was slightly decreased (S1: curve b').…”

Section: Fabrication Of Fmwcnts and Fmwcnts/p-att Modified Gc Electrodementioning

confidence: 99%

Selective determination of mefenamic acid in the presence of 1000-fold excess paracetamol and caffeine using a multiwalled carbon nanotube–polymer composite electrode

Rajalakshmi

John

2015

Anal. Methods

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ARTICLE This journal isThis article describes the selective and sensitive determination of Mefenamic acid (MA) using carboxylated multiwalled carbon nanotubes (FMWCNTs) -nanostructured conducting polymer (p-ATT) composite modified glassy carbon (GC) electrode in 0.2 M phosphate buffer solution (PBS, pH 7.2). The bare GC electrode failed to show a stable response for MA oxidation due to the surface fouling caused by the oxidized product of MA. However, the FMWCNTs/p-ATT composite electrode showed 2.4-fold higher oxidation current with 70 mV less positive potential for MA when compared to bare GC electrode. The higher electrocatalytic activity of MA at composite modified electrode may be due to the hydrogen bonding and electrostatic interactions between p-ATT and MA besides the π-π interaction between the FMWCNTs and p-ATT. Further, the FMWCNTs/p-ATT composite electrode showed extreme selectivity towards MA in the presence of 1000-fold excess of paracetamol (PA) and caffeine (CAF) and 3330-fold excess of other common interferences. The amperometric current response was increased linearly with increasing MA concentration in the range of 40-5000 nM with a correlation coefficient of 0.9980 and the limit of detection was found to be 90 pM (S/N=3). The practical application of the present modified electrode was successfully demonstrated by determining MA in commercial drug samples.

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“…It is also used for the reduction of fever of bacterial or viral origin [4]. Generally, PAR does not exhibit any harmful side effects, but at higher doses in few cases it will lead to the formation of some liver and nephrotoxic metabolites [5]. Given that PAR is being used increasingly for therapeutic purposes, its quantitative analysis is of vital importance.…”

Section: Introductionmentioning

confidence: 99%

Determination of Paracetamol Based on its Quenching Effect on the Photoluminescence of CdTe Fluorescence Probes

Ding

Cheng

et al. 2011

J Fluoresc

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L-Cysteine capped CdTe nanoparticles (NPs) were synthesized in aqueous medium, and their application as fluorescence probes in the determination of paracetamol was studied. The L-cysteine capped CdTe NPs were characterized by transmission electron microscopy, X-ray diffraction spectrometry, spectrofluorometry, ultraviolet-visible and Fourier transform infrared spectrometry. Based on the distinct fluorescence quenching of CdTe fluorescence probes in the presence of paracetamol, a simple, rapid and specific method for paracetamol determination was presented. Under optimum conditions, the relative fluorescence intensity of CdTe NPs was linearly proportional to paracetamol concentration from 1.0 × 10(-8) mol/L to 1.6 × 10(-7) mol/L with a detection limit of 4.2 × 10(-9) mol/L. The proposed method was applied to detect paracetamol in commercial tablets with satisfactory results.

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Selective Electrochemical Determination of Paracetamol Using Nanostructured Film of Functionalized Thiadiazole Modified Electrode

Cited by 20 publications

References 31 publications

MWCNT–CTAB modified glassy carbon electrode as a sensor for the determination of paracetamol

MWCNT–CTAB modified glassy carbon electrode as a sensor for the determination of paracetamol

Selective determination of mefenamic acid in the presence of 1000-fold excess paracetamol and caffeine using a multiwalled carbon nanotube–polymer composite electrode

Determination of Paracetamol Based on its Quenching Effect on the Photoluminescence of CdTe Fluorescence Probes

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