Selective Electrochemical Sensing Platform Based on the Synergy between Carbon Black and Single-Crystalline Bismuth Sulfide for Rapid Analysis of Antipyretic Drugs

Abstract

Nanomaterials are of significant interest in acetaminophen (APAP) detection in pharmaceutical samples. Herein, a carbon black/single-crystalline rodlike bismuth sulfide (CB/Bi2S3) composite prepared by an ultrasonic method is reported and utilized for the rapid analysis of APAP. The highly oriented edge reactive sites of the CB/Bi2S3 composite promoted synergy and good electrochemical sensing performance with a fast electron transfer rate and low overpotential (0.35 V). Therefore, a CB/Bi2S3 composite-modified glassy carbon electrode (GCE) was applied to the selective determination of APAP by the voltammetric technique. The CB/Bi2S3 composite-modified electrode showed the lowest limit of detection of APAP (1.9 nM) with excellent sensitivity. The proposed CB/Bi2S3/GCE platform exhibited high selectivity, excellent stability (87.15%), and reproducibility. Also, the CB/Bi2S3/GCE sensor was then successfully used to analyze an APAP pharmaceutical sample and exhibited satisfactory outcomes. Therefore, the CB/Bi2S3-modified GCE sensor platform would be a low-cost and robust GCE electrode material for APAP detection.

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