Selective electrochemical sensor for theophylline based on an electrode modified with imprinted sol–gel film immobilized on carbon nanoparticle layer

Güney, Sevgi; Cebeci, Fevzi Çakmak

doi:10.1016/j.snb.2014.10.056

Cited by 41 publications

(25 citation statements)

References 58 publications

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“…The proportional increase of the current response of TP was observed at a potential of +1. 18 Comparable results were also obtained with the utilization of a GCE modied by AuNPs/Chit-IL/Gr 47 and MIP/CNPs-SO 3 H. 22 Signicance of modication by MWCNTs obtained the best results in the case of CPEs. As can be seen, no signicant differences were observed between the values found for the TP amounts using the proposed and reference methods.…”

Section: Determination Of Tp In Pharmaceutical Dosages and Human Urinmentioning

confidence: 89%

“…In general, glassy carbon electrodes (GCEs) and carbon paste electrodes (CPEs) are the most frequently used materials. Voltammetric behavior of TP at a multi-walled carbon nanotube (MWCNT) modied CPE using DPV was studied by Malode et al 21 Recently, Güney et al 22 developed a new electrochemical sensor based on an imprinted hybrid sol-gel lm for selective and sensitive determination of TP in a drug sample. 18 This sensor showed excellent electrocatalytic activity towards the oxidation of TP in the presence of 0.1 mol L À1 sulphuric acid.…”

Section: Introductionmentioning

confidence: 99%

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Electroanalytical application of a boron-doped diamond electrode for sensitive voltammetric determination of theophylline in pharmaceutical dosages and human urine

et al. 2015

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In this paper, a novel voltammetric method for the determination of 1,3-dimethylxanthine alkaloid theophylline is elaborated using differential pulse (DPV) and square-wave voltammetric (SWV) modes on a boron-doped diamond electrode. Direct oxidation of the analyte at very positive potentials was observed by cyclic voltammetry, as evidenced by the presence of a well-shaped irreversible peak at +1.63 V (vs. Ag/AgCl electrode) in 1 mol L À1 sulphuric acid. After optimization of experimental conditions, the current response of theophylline was proportionally linear from 2 to 380 mmol L À1 using both pulse techniques. The developed electroanalytical method yielded low detection limits of 0.91 and 1.45 mmol L À1 associated with good intra-day repeatability (relative standard deviation of 3.2 and 2.5%) using DPV and SWV, respectively. The influence of some possible interferents was also evaluated. The practical feasibility of the proposed methodology was tested in the analysis of pharmaceutical dosages and human urine samples and good recovery values were accomplished (93.2-102.5%). The results of analysis of pharmaceuticals were also in close agreement at a 95% confidence level with those obtained using the titration (reference) method. Taking these attributes into consideration, the proposed sensor may be employed as a simple and effective analytical tool in drug control analysis and analysis of biological samples as well as a useful alternative to previously utilized modified electrodes in this field.

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Section: Determination Of Tp In Pharmaceutical Dosages and Human Urinmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Electroanalytical application of a boron-doped diamond electrode for sensitive voltammetric determination of theophylline in pharmaceutical dosages and human urine

et al. 2015

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“…Nowadays, more studies about the sol‐gel imprinting technique on surface are notified for incorporating amino‐functionalized silane as a functional monomer and template into inorganic network through tetraethyl orthosilicate as a cross‐linker by hydrolysis reaction . When the hydrolysis reaction starts, condensation of a series of silane monomers occurs, promoting the generation of sol‐gel networks.…”

Section: Introductionmentioning

confidence: 99%

Development of an Electrochemical Sensor Based on Covalent Molecular Imprinting for Selective Determination of Bisphenol‐A

Güney

2017

Electroanalysis

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In this study, an electrochemical sensor was developed and used for selective determination of bisfenol‐A (BPA) by integrating sol‐gel technique and multi‐walled carbon nanotubes (MWCNTs) modified paste electrode. BPA bounded by covalently to isocyanatopropyl‐triethoxy silane (ICPTS) was synthesized as a new precursor (BPA‐ICPTS) and then BPA‐imprinted polymer (BPA‐IP) sol‐gel was prepared by using tetramethoxysilane (TMOS) and BPA‐ICPTS. Non‐imprinted polymer (NIP) sol‐gel was obtained by using TMOS and (3‐Aminopropyl) triethoxysilane. Both BPA‐IP and NIP sol‐gels were characterized by nitrogen adsorption‐desorption analysis, FTIR, SEM, particle size analyzer and optical microscope. Carbon paste sensor electrode was fabricated by mixing the newly synthesized BPA‐IP with MWCNTs, graphite powder and paraffin oil. The electrochemical characterization of the sensor electrode was achieved with cyclic and differential pulse voltammetric techniques. The response of the developed sensor under the most proper conditions was linear in BPA concentration range from 4.0×10−9 to 1.0×10−7 mol L−1 and 5.0×10−7 to 5.0×10−5 mol L−1 and the detection limit was 4.4×10−9 mol L−1. The results unclosed that the proposed sensor displayed high sensitivity and selectivity, superior electrochemical performance and rapid response to BPA.

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“…Nowadays, there is a considerable interest to molecularly imprinted polymers (MIPs) which are promising electrode modifying agents for the evaluation of novel electrochemical sensors due to high recognition ability of imprinted polymers to the target molecule . MIPs are artificial polymers formed upon polymerization of complex structure that was produced by interaction between target molecule and functional monomers.…”

Section: Introductionmentioning

confidence: 99%

Electrosynthesis of Molecularly Imprinted Poly‐o‐phenylenediamine on MWCNT Modified Electrode for Selective Determination of Meldonium

Güney

2019

Electroanalysis

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In this study, a molecularly imprinted polymer (MIP) was synthesized by electrochemical polymerization and used to construct an electrochemical sensor for determination of meldonium (MEL) selectively for the first time. The polymer film was generated by using o‐phenylenediamine (o‐PD) as a monomer on the surface of carboxylic acid functionalized multiwalled carbon nanotube (MWCNT) modified pencil rod electrode in the presence of MEL as a template. MEL imprinted (MEL‐imp) and non‐imprinted (N‐imp) polymer films and coated electrodes were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), profilometry, electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Voltammetric measurements were carried out in a ferrocyanide/ferricyanide redox probe solution for MEL‐imp and N‐imp electrodes in the presence and absence of template molecule. The decrease in peak current of redox probe was linear with the concentration of MEL in the range of 0.1–5 μg/mL and the limit of detection (3 s/b) was found to be 0.066 μg/mL under optimized experimental conditions. The proposed sensor was successfully applied for selective determination of MEL in human urine sample with long term stability and good reproducibility.

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Selective electrochemical sensor for theophylline based on an electrode modified with imprinted sol–gel film immobilized on carbon nanoparticle layer

Cited by 41 publications

References 58 publications

Electroanalytical application of a boron-doped diamond electrode for sensitive voltammetric determination of theophylline in pharmaceutical dosages and human urine

Electroanalytical application of a boron-doped diamond electrode for sensitive voltammetric determination of theophylline in pharmaceutical dosages and human urine

Development of an Electrochemical Sensor Based on Covalent Molecular Imprinting for Selective Determination of Bisphenol‐A

Electrosynthesis of Molecularly Imprinted Poly‐o‐phenylenediamine on MWCNT Modified Electrode for Selective Determination of Meldonium

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