Selective enhancement of NMDA receptor-mediated locomotor hyperactivity by male sex hormones in mice

Buuse, Maarten van den; Low, Jac Kee; Kwek, Perrin; Martin, Sally; Gogos, Andrea

doi:10.1007/s00213-017-4668-8

Cited by 14 publications

(7 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some evidence indicates that NMDAR activity may be differently modulated according to sex. Gonadectomy alters mouse behavioral responses to the NMDAR agonist MK-801 in males but not females; male mice have higher NMDAR density in the NAc, motor and cingulate cortices (van den Buuse et al, 2017) and gonadal hormonal status influences both LTP induction and NMDAR function in male rats (Moradpour et al, 2013). Thus, SCE causes similar behavioral deficits in both male and female rats but triggered different alterations of PFC synapses.…”

Section: Discussionmentioning

confidence: 99%

Sex Differences in the Behavioral and Synaptic Consequences of a Single in vivo Exposure to the Synthetic Cannabimimetic WIN55,212-2 at Puberty and Adulthood

Borsoi

Manduca

Bara

et al. 2019

Front. Behav. Neurosci.

View full text Add to dashboard Cite

Heavy cannabis consumption among adolescents is associated with significant and lasting neurobiological, psychological and health consequences that depend on the age of first use. Chronic exposure to cannabinoid agonists during the perinatal period or adolescence alters social behavior and prefrontal cortex (PFC) activity in adult rats. However, sex differences on social behavior as well as PFC synaptic plasticity after acute cannabinoid activation remain poorly explored. Here, we determined that the consequences of a single in vivo exposure to the synthetic cannabimimetic WIN55,212-2 differently affected PFC neuronal and synaptic functions after 24 h in male and female rats during the pubertal and adulthood periods. During puberty, single cannabinoid exposure (SCE) reduced play behavior in females but not males. In contrast, the same treatment impaired sociability in both sexes at adulthood. General exploration and memory recognition remained normal at both ages and both sexes. At the synaptic level, SCE ablated endocannabinoid-mediated synaptic plasticity in the PFC of females of both ages and heightened excitability of PFC pyramidal neurons at adulthood, while males were spared. In contrast, cannabinoid exposure was associated with impaired long-term potentiation (LTP) specifically in adult males. Together, these data indicate behavioral and synaptic sex differences in response to a single in vivo exposure to cannabinoid at puberty and adulthood.

show abstract

Section: Discussionmentioning

confidence: 99%

Sex Differences in the Behavioral and Synaptic Consequences of a Single in vivo Exposure to the Synthetic Cannabimimetic WIN55,212-2 at Puberty and Adulthood

Borsoi

Manduca

Bara

et al. 2019

Front. Behav. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Therefore, premature responses in our study may be better characterized as an index of hyperactivity rather than impulsivity. Hyperactivity has been shown to be more prominent in males in a disease state compared to females (Acharjee et al 2014; van den Buuse et al 2017). Nevertheless, future studies should attempt to fade in timeouts for various incorrect responses potentially after the task has been acquired to help Tat transgenic mice learn the task.…”

Section: Discussionmentioning

confidence: 99%

Inhibitory Control Deficits Associated with Upregulation of CB1R in the HIV-1 Tat Transgenic Mouse Model of Hand

Jacobs

Hermes

et al. 2019

J Neuroimmune Pharmacol

View full text Add to dashboard Cite

In the era of combined antiretroviral therapy, HIV-1 infected individuals are living longer lives; however, longevity is met with an increasing number of HIV-1 associated neurocognitive disorders (HAND) diagnoses. The transactivator of transcription (Tat) is known to mediate the neurotoxic effects in HAND by acting directly on neurons and also indirectly via its actions on glia. The Go/No-Go (GNG) task was used to examine HAND in the Tat transgenic mouse model. The GNG task involves subjects discriminating between two stimuli sets in order to determine whether or not to inhibit a previously trained response. Data reveal inhibitory control deficits in female Tat(+) mice (p = .048) and an upregulation of cannabinoid type 1 receptors (CB1R) in the infralimbic (IL) cortex in the same female Tat(+) group (p < .05). A significant negative correlation was noted between inhibitory control and IL CB1R expression (r = −.543, p = .045), with CB1R expression predicting 30% of the variance of inhibitory control (R2 = .295, p = .045). Furthermore, there was a significant increase in spontaneous excitatory postsynaptic current (sEPSC) frequencies in Tat(+) compared to Tat(−) mice (p = .008, across sexes). The increase in sEPSC frequency was significantly attenuated by bath application of PF3845, a fatty acid amide hydrolase (FAAH) enzyme inhibitor (p < .001). Overall, the GNG task is a viable measure to assess inhibitory control deficits in Tat transgenic mice and results suggest a potential therapeutic treatment for the observed deficits with drugs which modulate endocannabinoid enzyme activity.

show abstract

“…Female rats exhibit higher levels of PPI compared to males at baseline (Nozari et al, 2015 ; Zhang X. et al, 2015 ; Gogos et al, 2017 ). NMDA receptor antagonist, MK-801, decreases PPI in both intact and gonadectomized male mice whereas female mice only exhibit this decrease following ovariectomy (van den Buuse et al, 2017 ). This suggests that circulating hormones protect females against NMDA receptor mediated disruption of PPI.…”

Section: Sex Differences In Glutamate Systems In Diseasementioning

confidence: 99%

Sex Differences in Psychiatric Disease: A Focus on the Glutamate System

Wickens

Bangasser

Briand

2018

Front. Mol. Neurosci.

View full text Add to dashboard Cite

Alterations in glutamate, the primary excitatory neurotransmitter in the brain, are implicated in several psychiatric diseases. Many of these psychiatric diseases display epidemiological sex differences, with either males or females exhibiting different symptoms or disease prevalence. However, little work has considered the interaction of disrupted glutamatergic transmission and sex on disease states. This review describes the clinical and preclinical evidence for these sex differences with a focus on two conditions that are more prevalent in women: Alzheimer's disease and major depressive disorder, and three conditions that are more prevalent in men: schizophrenia, autism spectrum disorder, and attention deficit hyperactivity disorder. These studies reveal sex differences at multiple levels in the glutamate system including metabolic markers, receptor levels, genetic interactions, and therapeutic responses to glutamatergic drugs. Our survey of the current literature revealed a considerable need for more evaluations of sex differences in future studies examining the role of the glutamate system in psychiatric disease. Gaining a more thorough understanding of how sex differences in the glutamate system contribute to psychiatric disease could provide novel avenues for the development of sex-specific pharmacotherapies.

show abstract

Selective enhancement of NMDA receptor-mediated locomotor hyperactivity by male sex hormones in mice

Cited by 14 publications

References 48 publications

Sex Differences in the Behavioral and Synaptic Consequences of a Single in vivo Exposure to the Synthetic Cannabimimetic WIN55,212-2 at Puberty and Adulthood

Sex Differences in the Behavioral and Synaptic Consequences of a Single in vivo Exposure to the Synthetic Cannabimimetic WIN55,212-2 at Puberty and Adulthood

Inhibitory Control Deficits Associated with Upregulation of CB1R in the HIV-1 Tat Transgenic Mouse Model of Hand

Sex Differences in Psychiatric Disease: A Focus on the Glutamate System

Contact Info

Product

Resources

About