Selective Estrogen Receptor Modulators and Phytoestrogens

Oseni, Tawakalitu O.; Patel, Roshani R.; Pyle, Jennifer R.; Jordan, V. Craig

doi:10.1055/s-0028-1088304

Cited by 190 publications

(129 citation statements)

References 124 publications

(150 reference statements)

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“…The osteogenic effects of phytoestrogens contained in medicinal plants are generally considered to occur through the modulation of the ERs (Oseni et al, 2008). Whether they can also promote estrogen biosynthesis by modulating aromatase, another mechanism to help maintain bone homeostasis (Ribot et al, 2006), is yet unknown.…”

Section: Discussionmentioning

confidence: 99%

“…Selective estrogen receptor modulators (SERMs), pharmaceutical agents that selectively activate or inhibit ERs, are used in the treatment of estrogen-related diseases, such as breast cancer or osteoporosis, depending on the target tissues (Bryant, 2002). The phytoestrogens in medicinal plants, mainly flavonoids, have long been considered to exert beneficial effects on estrogen-related diseases by acting as SERMs (Oseni et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Icariin from Epimedium brevicornum Maxim promotes the biosynthesis of estrogen by aromatase (CYP19)

Yang

Guo

et al. 2013

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Icariin from Epimedium brevicornum Maxim promotes the biosynthesis of estrogen by aromatase (CYP19)

Yang

Guo

et al. 2013

Journal of Ethnopharmacology

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“…Phytoestrogens are plant polyphenols with a chemical structure similar to that of estrogens. 49 A complicated role for these compounds has been proposed. For example, at low doses, phytoestrogens may prevent tamoxifen-induced reduction in mammary tumor formation.…”

Section: Cholesterol and Cellular Proliferationmentioning

confidence: 99%

Role of Cholesterol in the Development and Progression of Breast Cancer

Llaverı́as

Danilo

Mercier

et al. 2011

The American Journal of Pathology

270

237

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Breast cancer is the most commonly occurring cancer in women in Western societies. 1 It is estimated that 207,090 new cases will be diagnosed and that in the United States, 39,840 women will die of the disease in 2010 (American Cancer Society, Cancer Facts & Figures 2010, http://www. cancer.org/Research/cancer-facts-and-figures-2010, last accessed November 15, 2010. Interestingly, the incidence is about 5 times higher in Western countries than in developing countries. 2 Moreover, relocation and migrational studies have demonstrated that migration from a region with low incidence to a region with high incidence increases breast cancer incidence in the immigrant population. 3 These observations suggest a strong environmental influence on breast cancer development.Diet and obesity are now considered important risk factors for cancer development. 4,5 However, despite major modifications of its metabolism during obesity development and its function in tissue pathogenesis, little is known about the metabolism and role of plasma cholesterol in cancer development. Epidemiological studies have demonstrated that patients with cancer have abnormal levels of high-density lipoprotein (HDL)-cholesterol and low-density lipoprotein (LDL)-cholesterol, 6,7 which are the major lipoprotein carriers of cholesterol in human plasma. In addition, numerous studies have established that transformed cells and tumors exhibit abnormal regulation of several genes that are under the control of cholesterol. The products of these genes include the LDL receptor (LDL-R), hydroxy-methyl-glutaryl coenzyme A reductase (HMG-CoA Reductase), and their regulators, the sterol regulatory element binding proteins. 8 -13 As a consequence, these genes are dysregulated at the transcriptional level during tumorigenesis. These data suggest that transformed cells may require or utilize more cholesterol than normal cells, and this may be associated with their increased rate of proliferation. More recent studies have implicated HDL during tumor formation in breast cancer. 14 -16 However, their precise function remains controversial. The present study was performed to test the hypothesis that dietary cholesterol and plasma cholesterol levels have an important role in the regulation of breast cancer onset and progression.

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“…It has been suggested that phytoestrogens may possess a weak estrogenic, selective estrogen modulating (SERM) or antiestrogenic effects [14]. In the presence of estradiol, such compounds may also have an antagonistic effect and decrease the potency of estradiol.…”

Section: Discussionmentioning

confidence: 99%

Estrogen modulating effects of resveratrol in female rats

Özatik

Erol

Özatik

2016

MMJ

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Objectives: This study investigates the estrogen-like effects of resveratrol (RES) in female rats. Materials and Methods:In this two-step study on estrogenlike activity of RES, immature female rats (21 days old) were used in the first step and pubertal female rats (28 days old) with primary ovarian failure (POF) induced by 4-vinylcyclohexene diepoxide (VCD) were used in the second step. Possible agonistic and/or antagonistic effects of RES were investigated by using several parameters including the ratios of uterine/body weights (UBW), uterine dry/wet weights (UDWW) and body weight increase (BW%), bone density measurement, serum estradiol and vitamin D levels and histological evaluation. Results:In immature rats, RES resulted in an increase in UBW equal to that produced by 17 alpha-ethinyl estradiol (17alphaEE). The minimum effective dose for RES was 10 mg/kg. This effect was not decreased by tamoxifen but was significantly antagonized by fulvestrant. Similarly, tamoxifen did not abolish the effects of RES completely in rats with POF. However, in rats with VCDinduced POF, tamoxifen resulted in lower UBW values and estradiol levels were significantly higher in 17alphaEE-treated, RES+tamoxifen-treated and 17 beta-estradiol (17betaE)-treated rats compared to control animals. Conclusion:The dose of RES may be important in terms of estrogenic activity and even RES may modulate the effects of estrogen. Keywords Bulgular:İmmatür sıçanlarda UA/VA oranları değerlendirmesinde RES, UA/VA oranını 17 alfa-etinil estradiol (17alfaEE)'e benzer bir şekilde arttırmıştır. En düşük anlamlı etki 10 mg/kg RES dozunda görülmüştür. Bu etki tamoksifen ile azalmazken fulvestrant ile anlamlı bir şekilde antagonize edilmiştir. POY oluşturulmuş dişi sıçanlarda da tamoksifen, RES'ün etkilerini tamamen ortadan kaldırmamıştır. UA/VA değerleri açısından POY geliştirilmiş sıçanlarda VCD+RES10mg/kg+tamoksifen verilen grubun ortalama değerlerinin, VCD+RES 10mg/kg verilen grubun ortalama değerlerinden daha düşüktür. POY geliştirilmiş sıçanlarda estradiol değerleri incelendiğinde, VCD+17alfaEE, sıçanlarda VCD+RES 10mg/kg+tamoksifen ve VCD+17 betaestradiol (17betaE) verilen gruplarda estradiol değerlerinin kontrol değerlerine göre anlamlı derecede arttığı gözlenmektedir.Sonuç: Çalışmamızın sonucuna göre estrojenik aktivite açısından RES'ün dozu önemli bir faktör olabilir ve RES'ün estrojen modülatörü olarak etki ettiği söylenebilir.Anahtar kelimeler: Estrojen, Resveratrol, 4-vinilsikloheksen diepoksid, Primer over yetmezliği

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Selective Estrogen Receptor Modulators and Phytoestrogens

Cited by 190 publications

References 124 publications

Icariin from Epimedium brevicornum Maxim promotes the biosynthesis of estrogen by aromatase (CYP19)

Icariin from Epimedium brevicornum Maxim promotes the biosynthesis of estrogen by aromatase (CYP19)

Role of Cholesterol in the Development and Progression of Breast Cancer

Estrogen modulating effects of resveratrol in female rats

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