Selective expression of adult β-globin but not embryonic y-globin genes in hybrids of mouse yolk-sac and erythroleukemia cells

Genetic Analysis of Mammalian Cell Differentiation

“…In such hybrids, tissue-specific products of both parents continue to be expressed. For example, hepatoma x hepatocyte (Szpirer et al 1980;Gourdeau et al 1989) and hepatoma x hepatoma (Cassio & Weiss 1979) hybrids express liver functions, and intra typic erythroid (Papayannopoulou et al 1985;Obinata et al 1985), lymphoblastoid (Riley et aI1981), and muscle (Quinn et al 1981) cell hybrids express tissue-specific markers of the respective cell types. One well-known and particularly useful intratypic somatic hybrid is the hybridoma cell: a hybrid generated by fusing cultured myeloma cells with antigen-stimulated B-cells.…”