Selective expression of neurotrophin-3 messenger RNA in muscle spindles of the rat

Copray, J.C.V.M.; Brouwer, Nieske

doi:10.1016/0306-4522(94)90578-9

Cited by 100 publications

(68 citation statements)

References 43 publications

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“…Satellite cells are known to be present within the inner capsule of the muscle spindle (Bird 1978), and the intrafusal muscle fibers of muscle spindles are also known to be capable of regeneration in the same manner as extrafusal muscle fibers (Maier 1997). Muscle spindles show selective expression of neurotrophin-3 (Copray and Brouwer 1994), adhesion molecules (Maier and Mayne 1995), and high Pax7 (Rodger et al 1999), but this is the first report demonstrating the presence of TNF-␣. Staining of intrafusal myofibers of muscle spindles indicates that a response of both extrafusal (i.e., "normal") and intrafusal (i.e., spindle) muscle fibers to injury is the production of TNF-␣.…”

Section: Immunostaining Of Normal and Regenerating Musclementioning

confidence: 91%

The Role of Tumor Necrosis Factor-alpha (TNF-α) in Skeletal Muscle Regeneration

Collins

Grounds²

2001

J Histochem Cytochem.

147

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The role of tumor necrosis factor-alpha (TNF-α), an important mediator of the inflammatory response after injury, was investigated in regenerating skeletal muscle. The pattern of expression of TNF-α during muscle regeneration was examined by immunohistochemistry in tissue sections of crush-injured or transplanted muscle autografts and in primary cultures of adult skeletal muscle. TNF-α was highly expressed in injured myofibers, inflammatory cells, endothelial cells, fibroblasts, and mast cells. Myoblasts and myotubes also expressed TNF-α in primary muscle cultures and tissue sections. The essential role of TNF-α and its homologue lymphotoxin-alpha (LT-α) during muscle regeneration was assessed by basic histology in TNF-α(–) and TNF-α(-/-)/LT-α(-/-) mice. No difference was apparent in the onset or pattern of muscle regeneration (i.e., inflammatory response, activation and fusion of myoblasts) between the two strains of null mice or between nulls and normal control mice. However, both strains of null mice appeared more prone to bystander damage of host muscle and regeneration distant from the site of injury/transplantation. Although expression of TNF-α may play an important role in muscle regeneration, the studies in the null mice show that redundancy within the cytokine system (or some other response) can effectively compensate for the absence of TNF-α in vivo. (J Histochem Cytochem 49:989–1001, 2001)

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Section: Immunostaining Of Normal and Regenerating Musclementioning

confidence: 91%

The Role of Tumor Necrosis Factor-alpha (TNF-α) in Skeletal Muscle Regeneration

Collins

Grounds²

2001

J Histochem Cytochem.

147

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“…during development of sympathetic neurons, NT3 expression is activated by Nrg1 (Verdi et al, 1996). Likewise, muscle spindles express NT3 (Copray and Brouwer, 1994) and muscle spindles are absent in NT3-deficient mice (Farinas et al, 1994). This raises the possibility that NT3 is more generally a downstream effector of Nrg1/Erbb signaling, and that it is an essential component by which Erbb2 regulates muscle spindle development.…”

Section: Erbb2 Functions In Muscle Spindle Developmentmentioning

confidence: 99%

“…Interestingly, NT3 regulates the survival of proprioceptive sensory neurons prior to innervation of muscle spindles, but is also required for the survival of Ia afferent neurons once they reach their target (ElShamy and Ernfors, 1996;ElShamy et al, 1998;Oakley et al, 1995;Oakley et al, 1997;Ockel et al, 1996;Ringstedt et al, 1997;Wright et al, 1997). NT3 is expressed in spindles, and maintenance of NT3 expression is dependent on nerve contact (Chen et al, 2002;Copray and Brouwer, 1994). These data suggest the existence of a regulatory loop, where yet to be defined neuronal signals induce muscle spindle formation and NT3 expression, while NT3 serves to maintain Ia afferent neurons.…”

Section: Introductionmentioning

confidence: 99%

Erbb2 regulates neuromuscular synapse formation and is essential for muscle spindle development

et al. 2003

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“…ISH was performed as described (Copray and Brouwer 1994). In brief, the L-CCR PCR product was cloned into the dual promoter PCR II vector and linearized.…”

Section: In Situ Hybridization (Ish)mentioning

confidence: 99%