2004
DOI: 10.1016/j.molbrainres.2003.11.014
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Selective expression of regulators of G-protein signaling (RGS) in the human central nervous system

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Cited by 143 publications
(125 citation statements)
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“…229 Again, the original three marker haplotypes positive in the Irish study were not overtransmitted in this sample, and the authors did not report their individual SNP analyses. Van den Bogaert et al 230 typed four of the most positive SNPs from the earlier studies, spanning introns 3 and 4, and an additional marker contained within the high-risk haplotypes, and examined three case-control samples, from Germany (418 cases, 285 controls), Poland (294,113), and Sweden (142,272). These had to be studied separately because variable allele frequencies were found between the control groups, starkly illustrating the potential for stratification errors even in studies of European populations.…”
Section: Dysbindin (Dtnbp1)mentioning
confidence: 99%
See 1 more Smart Citation
“…229 Again, the original three marker haplotypes positive in the Irish study were not overtransmitted in this sample, and the authors did not report their individual SNP analyses. Van den Bogaert et al 230 typed four of the most positive SNPs from the earlier studies, spanning introns 3 and 4, and an additional marker contained within the high-risk haplotypes, and examined three case-control samples, from Germany (418 cases, 285 controls), Poland (294,113), and Sweden (142,272). These had to be studied separately because variable allele frequencies were found between the control groups, starkly illustrating the potential for stratification errors even in studies of European populations.…”
Section: Dysbindin (Dtnbp1)mentioning
confidence: 99%
“…On the other hand, RGS4 certainly has some biological plausibility as a schizophrenia gene. It is the most brain-enriched of the 19 human RGS transcripts, 272 and is abundant in the cerebral cortex, with much lower levels in thalamus and basal ganglia.…”
Section: Regulator Of G-protein Signalling 4 (Rgs4)mentioning
confidence: 99%
“…Tissue-specific patterns of RGS protein expression in the human peripheral tissues and brain were reported by Larminie and his group (13). They showed that the major RGS10 proteins in human lymphocytes are RGS1, RGS2, RGS10, RGS13, RGS14, RGS16, and RGS18 (13). The RGS proteins may acquire functional diversity in immune cells by a fine-tuned and dynamic regulation of the expression of multiple RGS proteins.…”
Section: Introductionmentioning
confidence: 94%
“…Located on chromosome 1q23.3, the RGS4 gene (Online Mendelian Inheritance in Men database entry 602516) is a 7 kb sequence encoding a 23.3 kDa protein of 205 amino acids. Across species, RGS4 is highly expressed in neocortex, striatum, and the hippocampus (Gold et al, 1997;Nomoto et al, 1997;Ingi and Aoki, 2002;Erdely et al, 2004;Larminie et al, 2004). RGS4 modulates G-protein signaling in a number of neurotransmitter systems, several of which have been linked to schizophrenia, including metabotropic glutamate (Saugstad et al, 1998;De Blasi et al, 2001), dopamine (Yan et al, 1997;Ghavami et al, 2004), and serotonin (Beyer et al, 2004;Ghavami et al, 2004) receptors.…”
Section: Introductionmentioning
confidence: 99%