Selective extraction of female hormones using aqueous two-phase system composed of double protic ionic liquid + acetonitrile

Buarque, Filipe Smith; Barreto, Victor; Soares, Cleide Mara Faria; Souza, Ranyere Lucena de; Pereira, Matheus M.; Lima, Álvaro Silva

doi:10.1016/j.fluid.2019.112443

Cited by 18 publications

(17 citation statements)

References 41 publications

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“…The integrated process for atrazine isolation and the recycling and reuse of phase‐forming components studied in this work is also further supported by other studies already published in the literature comprising the recycling and reuse of both ATPS phases (Alencar et al., 2020; Buarque et al., 2019, 2020). The process herein proposed offers a sustainable and more efficient recovery/concentration alternative to the current techniques for the separation of atrazine from water samples that can, with little effort, be extended to other bodies of water (river, surface water, groundwater, wastewater).…”

Section: Resultssupporting

confidence: 85%

“…(2016, 2017) and Buarque et al. (2020) when partitioning diuron herbicide in an ATPS based on THF. Tian et al.…”

Section: Resultsmentioning

confidence: 99%

“…Glycerol can be separated from the real water sample by precipitation with alcohol through the salting‐out effect. With the addition of an alcohol such as ethanol, isopropanol, or n ‐butanol, the interactions between alcohols and glycerol will be dominated by hydrogen bonds, thus decreasing the solubility of glycerol in water (Gutiérrez et al., 2013 and Buarque et al., 2020). Alcohol has a lower boiling temperature than glycerol and can thus be separated by applying to the rotary evaporator.…”

Section: Resultsmentioning

confidence: 99%

“…Although widely studied in the past decades, conventional polymer‐based ATPS display a high viscosity, which hinders the mass transfer and the phase separation; and they have a limited polarity range between the two phases (Freire, 2016). Therefore, these systems have restricted applicability, leading to the development of new systems formed by different constituents such as ionic liquids (Gutowski et al., 2003), organic solvents, for example, alcohols (Tan et al., 2014), acetonitrile (Buarque et al., 2020), and tetrahydrofuran (THF; Buarque et al., 2019).…”

Section: Introductionmentioning

confidence: 99%

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Preconcentration and chromatographic detection of atrazine in real water sample using aqueous two‐phase system based on tetrahydrofuran and glycerol

Buarque

Lima

Soares

et al. 2021

Environmental Quality Mgmt

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Environmental contamination by atrazine leads to serious environmental impact. The low concentrations of atrazine in aqueous media render its identification and quantification difficult. In this context, aqueous two‐phase systems based on tetrahydrofuran (THF) + glycerol were tested as simultaneous recovery and preconcentration platforms of atrazine from real water samples. The phase diagrams were determined, and it was reported that the phase separation ability largely depends on the number of hydroxyl groups present in each polyol. Posteriorly, the atrazine was partitioned to the THF‐rich phase and presented recovery values between 70.9 (KATZ = 2.9) and 96.5% (KATZ = 15.2). The computational predictive method (COSMO‐RS) was used, aiming to confirm the atrazine partitioning for the THF‐rich phase. In addition, a 250‐fold preconcentration factor was achieved using a mixture point of 3.27 wt% of THF + 93.98 wt% of glycerol + 2.75 wt% of real water sample. This preconcentration factor and subsequent use of UFLC‐TOF permitted the identification and quantification of atrazine in real samples of water collected in the hydrographic basin from the Japaratuba River, in the state of Sergipe, Brazil. The protocol presented values of 95‒2400 ng L−1 of atrazine with a limit of detection of 50 ng L−1.

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Section: Resultssupporting

confidence: 85%

“…(2016, 2017) and Buarque et al. (2020) when partitioning diuron herbicide in an ATPS based on THF. Tian et al.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Preconcentration and chromatographic detection of atrazine in real water sample using aqueous two‐phase system based on tetrahydrofuran and glycerol

Buarque

Lima

Soares

et al. 2021

Environmental Quality Mgmt

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“…Further expanding the diversity of phase-forming components of IL-based ABS and pharmaceuticals recovered, the use of polar organic solvents as well as antidepressants and hormones was recently reported by Lima's research group [178,179]. A series of ILs belonging to the imidazolium family, while bearing distinct anions and cation alkyl chain lengths ([C n C 1 im]X, with n = 2-10 and X = Clas well as n = 2 and X…”

Section: Il-based Absmentioning

confidence: 99%

Advances Brought by Hydrophilic Ionic Liquids in Fields Involving Pharmaceuticals

et al. 2021

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The negligible volatility and high tunable nature of ionic liquids (ILs) have been the main drivers of their investigation in a wide diversity of fields, among which is their application in areas involving pharmaceuticals. Although most literature dealing with ILs is still majorly devoted to hydrophobic ILs, evidence on the potential of hydrophilic ILs have been increasingly provided in the past decade, viz., ILs with improved therapeutic efficiency and bioavailability, ILs with the ability to increase drugs' aqueous solubility, ILs with enhanced extraction performance for pharmaceuticals when employed in biphasic systems and other techniques, and ILs displaying low eco/cyto/toxicity and beneficial biological activities. Given their relevance, it is here overviewed the applications of hydrophilic ILs in fields involving pharmaceuticals, particularly focusing on achievements and advances witnessed during the last decade. The application of hydrophilic ILs within fields involving pharmaceuticals is here critically discussed according to four categories: (i) to improve pharmaceuticals solubility, envisioning improved bioavailability; (ii) as IL-based drug delivery systems; (iii) as pretreatment techniques to improve analytical methods performance dealing with pharmaceuticals, and (iv) in the recovery and purification of pharmaceuticals using IL-based systems. Key factors in the selection of appropriate ILs are identified. Insights and perspectives to bring renewed and effective solutions involving ILs able to compete with current commercial technologies are finally provided.

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Hormones Concentration in an Aqueous Two‐Phase System: Experimental and Computational Analysis

Buarque,

Lima,

Carniel

et al. 2024

Chem Eng & Technol

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Estrogens are emergent pollutants found in low levels in water bodies, and for this reason they require concentration for quantification. In this study, aqueous two‐phase systems (ATPSs) were used as an alternative strategy to improve hormone detection and quantification from real water samples. In addition, a predictive computational method (COSMO‐RS) was used to understand better the migration of hormones between the two phases at the molecular level. Water samples previously analyzed as hormone‐free were added to the 250‐fold concentrated ATPS, where it was possible to detect and quantify concentrations of these micropollutants in the range of 9.3–29.19 ng L−1.

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Selective extraction of female hormones using aqueous two-phase system composed of double protic ionic liquid + acetonitrile

Cited by 18 publications

References 41 publications

Preconcentration and chromatographic detection of atrazine in real water sample using aqueous two‐phase system based on tetrahydrofuran and glycerol

Preconcentration and chromatographic detection of atrazine in real water sample using aqueous two‐phase system based on tetrahydrofuran and glycerol

Advances Brought by Hydrophilic Ionic Liquids in Fields Involving Pharmaceuticals

Hormones Concentration in an Aqueous Two‐Phase System: Experimental and Computational Analysis

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