Selective Fabrication of α- and γ-Polymorphs of Glycine by Intense Polarized Continuous Wave Laser Beams

Yuyama, Ken‐ichi; Rungsimanon, Thitiporn; Sugiyama, Teruki; Masuhara, Hiroshi

doi:10.1021/cg300065x

Cited by 56 publications

(89 citation statements)

References 46 publications

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“…28 The fact that crystallization View Article Online occurs after minutes, and that crystallization takes place even in undersaturated (S = 0.68) solutions, demonstrates the sustained influence of the laser on the solution. As noted in the Introduction, however, we limit our ongoing discussion to polarization switching in the (nanosecond) pulsed NPLIN experiments used here.…”

Section: Polarization Switchingmentioning

confidence: 99%

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Supersaturation dependence of glycine polymorphism using laser-induced nucleation, sonocrystallization and nucleation by mechanical shock

Liu

Berg

Alexander

2017

Phys. Chem. Chem. Phys.

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The nucleation of glycine from aqueous supersaturated solution has been studied using nonphotochemical laser-induced nucleation (NPLIN), ultrasound (sonocrystallization), and mechanical shock of sample vials. It was found that at higher supersaturation, samples were more susceptible to nucleation and produced more of the g-glycine polymorph. The results are described in terms of a mechanism common to all three nucleation methods, involving the induction of cavitation events and pressure shockwaves. The switch in preference from a-to g-glycine was observed to occur over a narrower range of supersaturation values for NPLIN. We attribute this to induction of cavitation events with higher energies, which result in higher localized pressures and supersaturations. Experiments on NPLIN using circularly versus linearly polarized light showed no evidence for binary polarization switching control of glycine polymorphism.

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Section: Polarization Switchingmentioning

confidence: 99%

“…27 The effects of polarization were considered to be similar to those observed by Garetz et al, with CP light acting preferentially on native clusters that favour a-glycine. 28 At high laser powers, the trapping increased, and more g-glycine was nucleated. At very high powers, heating competed with trapping, and g-glycine became less favourable.…”

mentioning

confidence: 99%

Supersaturation dependence of glycine polymorphism using laser-induced nucleation, sonocrystallization and nucleation by mechanical shock

Liu

Berg

Alexander

2017

Phys. Chem. Chem. Phys.

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“…For glycine, a few polymorphs are well known and its aform is generally prepared in aqueous solution. We have extended a series of experiments showing how a-and cforms are prepared for glycine depending on linearly polarized (LP) and circularly polarized (CP) laser beams [18][19][20]. We succeeded in demonstrating selective preparation of c-form by trapping at the solution surface of the unsaturated solution of glycine.…”

Section: Crystal Polymorph Control By Laser Power and Polarizationmentioning

confidence: 93%

“…Thus, crystal polymorph control was expected, and indeed it has been demonstrated for glycine and L-phenylalanine in our laboratory. The former was already published [18][19][20], whereas the latter will be reported in the near future. It is worth remembering that one single crystal is always formed at the focus upon laser trapping as illustrated in Fig.…”

Section: Crystal Polymorph Control By Laser Power and Polarizationmentioning

confidence: 97%

Optical trapping assembling of clusters and nanoparticles in solution by CW and femtosecond lasers

Masuhara

Sugiyama

Yuyama

et al. 2015

Opt Rev

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Laser trapping of molecular systems in solution is classified into three cases: JUST TRAPPING, EXTEN-DED TRAPPING, and NUCLEATION and GROWTH. The nucleation in amino acid solutions depends on where the 1064-nm CW trapping laser is focused, and crystallization and liquid-liquid phase separation are induced by laser trapping at the solution/air surface and the solution/glass interface, respectively. Laser trapping crystallization is achieved even in unsaturated solution, on which unique controls of crystallization are made possible. Crystal size is arbitrarily controlled by tuning laser power for a plate-like anhydrous crystal of L-phenylalanine. The a-or c-crystal polymorph of glycine is selectively prepared by changing laser power and polarization. Further efficient trapping of nanoparticles and their following ejection induced by femtosecond laser pulses are introduced as unique trapping phenomena and finally future perspective is presented.

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“…10 However, a laser-induced nucleation experiment using CW lasers did reliably show polarisation-control over polymorph selection. 11 Thus, it is fair to say that a physical understanding of these phenomena is still sorely lacking.…”

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confidence: 99%

Control over phase separation and nucleation using a laser-tweezing potential

Walton

Wynne

2018

Nature Chem

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Control over the nucleation of new phases is highly desirable but elusive. Even though there is a long history of crystallisation engineering by varying physicochemical parameters, controlling which polymorph crystallises or whether a molecule crystallises or forms an amorphous precipitate is still a black art. Although there are now numerous examples of control using laserinduced nucleation, a physical understanding is absent and preventing progress. Here we show that the proximity of a liquid-liquid critical point or the corresponding binodal line can be used by a laser-tweezing potential to induce concentration gradients. A simple theoretical model shows that the stored electromagnetic energy of the laser beam produces a free-energy potential that forces phase separation or triggers the nucleation of a new phase. Experiments in a liquid mixture using a low-power laser diode confirm the effect. Phase separation and nucleation through a laser-tweezing potential explains the physics behind non-photochemical laser-induced nucleation and suggests new ways of manipulating matter.The nucleation of new phases such as crystals from solution is of enormous technological importance but poorly understood. Although the vast majority of pharmaceutical products and most fine and speciality chemical products are made in crystalline form, industrial crystallisation has changed little in the past 350 years and suffers from an embarrassing lack of control with sometimes unexpected and severe financial consequences.1 Therefore, a deeper understanding of and control over (crystal) nucleation is of great importance.Two decades ago, it was shown that nanosecond pulsed lasers can nucleate crystals in a supersaturated solution through a non-photochemical process.2 Most significantly, it was shown that the crystal polymorph could be selected by the polarisation state of the laser.3 Subsequent work has shown that laser pulses can induce nucleation of various crystals, 4,5 liquid crystals, 6,7 and bubbles. 8 It was initially suggested that the Kerr effect was responsible for laser-induced nucleation 2 but subsequent work has shown that the data are inconsistent with it. 9 Most disconcertingly, the reproducibility of polarisation-control over polymorph selection has been questioned while pulsedlaser induced nucleation appears to require impurity particles.10 However, a laser-induced nucleation experiment using CW lasers did reliably show polarisation-control over polymorph selection.11 Thus, it is fair to say that a physical understanding of these phenomena is still sorely lacking.In a supersaturated solution, the crystal is the thermodynamically most stable state but is difficult to access in the absence of heterogeneous nucleation sites. In the simplest case, random fluctuations lead to the formation of a critical nucleus and ultimately a macroscopic crystal. As suggested by Frenkel for proteins 12 and more generally in non-classical nucleation theories, 13-15 the concentration fluctuations leading to nucleation may well be enhanced by...

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Selective Fabrication of α- and γ-Polymorphs of Glycine by Intense Polarized Continuous Wave Laser Beams

Cited by 56 publications

References 46 publications

Supersaturation dependence of glycine polymorphism using laser-induced nucleation, sonocrystallization and nucleation by mechanical shock

Supersaturation dependence of glycine polymorphism using laser-induced nucleation, sonocrystallization and nucleation by mechanical shock

Optical trapping assembling of clusters and nanoparticles in solution by CW and femtosecond lasers

Control over phase separation and nucleation using a laser-tweezing potential

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