Selective homocysteine lowering gene transfer attenuates the development of pressure overload-induced cardiomyopathy in mice

Abstract

Plasma homocysteine levels predict heart failure incidence in prospective epidemiological studies.We evaluated whether selective homocysteine lowering gene transfer beneficially affects cardiac remodelling and function in a model of pressure overload-induced cardiomyopathy induced by transverse aortic constriction (TAC). Female C57BL/6 low-density lipoprotein receptor (Ldlr