Selective human cells in vitro transduction with porcine endogenous retrovirus (PERV)

Gałka, Sabina; Nowak, Ewa; Bednarek, Ilona

doi:10.4149/av_2022_201

2022

DOI: 10.4149/av_2022_201

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Selective human cells in vitro transduction with porcine endogenous retrovirus (PERV)

Sabina Gałka¹,

Ewa Nowak²,

Ilona Bednarek³

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2024

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Cited by 1 publication

References 39 publications

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Advances in Organ and Tissue Xenotransplantation

Ali,

Kemter,

Wolf

2024

Annu. Rev. Anim. Biosci.

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End-stage organ failure can result from various preexisting conditions and occurs in patients of all ages, and organ transplantation remains its only treatment. In recent years, extensive research has been done to explore the possibility of transplanting animal organs into humans, a process referred to as xenotransplantation. Due to their matching organ sizes and other anatomical and physiological similarities with humans, pigs are the preferred organ donor species. Organ rejection due to host immune response and possible interspecies infectious pathogen transmission have been the biggest hurdles to xenotransplantation's success. Use of genetically engineered pigs as tissue and organ donors for xenotransplantation has helped to address these hurdles. Although several preclinical trials have been conducted in nonhuman primates, some barriers still exist and demand further efforts. This review focuses on the recent advances and remaining challenges in organ and tissue xenotransplantation. Expected final online publication date for the Annual Review of Animal Biosciences, Volume 12 is February 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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Advances in Organ and Tissue Xenotransplantation

Ali,

Kemter,

Wolf

2024

Annu. Rev. Anim. Biosci.

View full text Add to dashboard Cite

show abstract

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Selective human cells in vitro transduction with porcine endogenous retrovirus (PERV)

Cited by 1 publication

References 39 publications

Advances in Organ and Tissue Xenotransplantation

Advances in Organ and Tissue Xenotransplantation

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