Selective IgA Deficiency in Blood Donors

Koistinen, J.

doi:10.1111/j.1423-0410.1975.tb00494.x

Cited by 160 publications

(74 citation statements)

References 20 publications

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“…IgA deficiency is a common immunologic abnormality which may affect as many as 1 out of every 700 individuals (8). The majority do not have symptoms referable to deficient immunity, but for the minority who do have symptoms, sinopulmonary infections, allergic reactions, and frequent gastrointestinal and arthritic complaints are common (9).…”

Section: Discussionmentioning

confidence: 99%

Milk Precipitins, Circulating Immune Complexes and IgA Deficiency

Cunningham‐Rundles

et al. 1978

Advances in Experimental Medicine and Biology

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Twenty-two patients with selective IgA deficiency were studied for the presence of serum precipitins to bovine milk, bovine and fetal calf serum, and circulating immune complexes. Fifty-nine percent had circulating immune complexes, 50% had milk precipitins, 23% had precipitins to bovine serum, and 13% had precipitins to fetal calf serum. All patients with precipitating antibodies against milk or against bovine or fetal calfserum had circulating immune complexes and the precipitin titers correlated with the amount of circulating immune complexes. After one IgA-deficient patient had drunk 100 ml of milk, studies of sequential serum samples showed the presence of casein in the circulation at 60 min and the appearance of increasing amounts of immune complexes for 120 min. These findings are interpreted to indicate that in human beings the IgA system may provide a major barrier to absorption of immunogens from the gastrointestinal tract.

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Section: Discussionmentioning

confidence: 99%

Milk Precipitins, Circulating Immune Complexes and IgA Deficiency

Cunningham‐Rundles

et al. 1978

Advances in Experimental Medicine and Biology

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“…Selective IgA deficiency is found in one in 400 -500 of the general population. 16,17 With this exception, antibody deficiencies are rare disorders (e.g. CVID, 1 in 10,000) and as such often not recognized early in the disease process.…”

Section: Discussionmentioning

confidence: 99%

Immunoglobulin E deficiency: a forgotten clue pointing to possible immunodeficiency?

2011

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Background: Patients with primary antibody deficiency often have delayed diagnosis. Very low IgE, found during investigations for allergy, may be a marker for other immunodeficiency. Methods: We introduced a new laboratory policy of testing cases with very low IgE levels for possible linked antibody deficiency. The data represent an audit of routine results collected over two years. Results: Very low IgE ( 2 IU/mL) was identified in 85/2622 (3.2%) routine patient samples. Two children and four adult patients were found to have one or more classes of immunoglobulin below the reference range for age. In 2/6, the initiative of the laboratory led to a new unsuspected diagnosis of antibody immunodeficiency. Conclusions: Common variable immunodeficiency continues to be overlooked as a primary cause of lung disease in adults. Very low serum IgE should trigger appropriate investigation (immunoglobulin quantification and serum electrophoresis).

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“…They had been screened from apparently heathy adult blood donors by double diffusion and haemagglutination inhibition methods in the Finnish Red Cross Blood Transfusion Service in the years 1971±80 [13]. In 1992, the concentration of IgA was redeterminated in fresh serum samples by an enzyme immunoassay (EIA) [14,15].…”

Section: Study Subjectsmentioning

confidence: 99%

The significance of IgG subclasses and mannan-binding lectin (MBL) for susceptibility to infection in apparently healthy adults with IgA deficiency

Aittoniemi

Koskinen

Laippala

et al. 1999

Clinical and Experimental Immunology

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SUMMARYThe aim of this study was to investigate the signi®cance of IgG subclasses and MBL for susceptibility to infection in association with IgA de®ciency. The study population consisted of 139 apparently healthy adult blood donors with IgA de®ciency and normal serum levels of IgG and IgM, and an increased susceptibility to infection demonstrated at a population level. Additionally, 216 controls matched for age and sex were investigated. IgG4 de®ciency was more common and the mean level of IgG4 lower in persons with IgA de®ciency than in the controls. No signi®cant associations could be demonstrated between overt IgG subclass de®ciencies and increased susceptibility to infection. However, when the mean concentrations of IgG subclasses were analysed with regard to medical history, that of IgG1 was lower in persons who reported recurrent viral respiratory infections, that of IgG3 in persons who had episodes of severe infection in their history, and that of IgG4 in persons who had recurrent mild respiratory infections, compared with those who had no particular history of infections. In contrast, MBL de®ciencyÐalone or combined with that of the IgG subclassÐwas not associated with increased susceptibility to infection in persons with IgA de®ciency. The results indicate that the proneness to infections observed in a population of otherwise healthy persons with IgA de®ciency can only for a small part be accounted for by concomitant de®ciencies of IgG subclasses. Contrary to expectations, no synergism between the de®ciencies of IgA and MBL could be demonstrated.

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Selective IgA Deficiency in Blood Donors

Cited by 160 publications

References 20 publications

Milk Precipitins, Circulating Immune Complexes and IgA Deficiency

Milk Precipitins, Circulating Immune Complexes and IgA Deficiency

Immunoglobulin E deficiency: a forgotten clue pointing to possible immunodeficiency?

The significance of IgG subclasses and mannan-binding lectin (MBL) for susceptibility to infection in apparently healthy adults with IgA deficiency

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