Selective IgE deficiency, immune dysregulation, and autoimmunity

Magen, Eli; Schlesinger, Menachem; David, M. Ojcius; Ben-Zion, Itzhak; Vardy, Daniel

doi:10.2500/aap.2014.35.3734

Cited by 56 publications

(77 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…15,588,589,[596][597][598][599] A number of selective Ig deficiencies, specifically those involving IgG3 subclass, IgA, and IgM, have been consistently identified in this group of patients. 585,586,590,593,594,[596][597][598][600][601][602] Preimmunization antipneumococcal titers have been shown to be decreased as well, particularly in patients with the more severe forms of immunodeficiency such as CVID.…”

Section: Discussionmentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

557

888

View full text Add to dashboard Cite

Background:The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). Methods:Evidence-based reviews with recommendations (EBRRs) were developed for scores of topics, using previously reported methodology. Where existing evidence was insufficient for an EBRR, an evidence-based review (EBR) was produced. The sections were then synthesized and the entire manuscript was then reviewed by all authors for consensus. Results:The resulting ICAR:RS document addresses multiple topics in RS, including acute RS (ARS), chronic RS (CRS) with and without nasal polyps (CRSwNP and CRSsNP), recurrent acute RS (RARS), acute exacerbation of CRS (AE-CRS), and pediatric RS. Conclusion:As a critical review of the RS literature, ICAR:RS provides a thorough review of pathophysiology and evidence-based recommendations for medical and surgical treatment. It also demonstrates the significant gaps in our understanding of the pathophysiology and optimal management of RS. Too o en the foundation upon which these recommendations are based is comprised of lowerlevel evidence. It is our hope that this summary of the evidence in RS will point out where additional research efforts may be directed. C 2016 ARS-AAOA, LLC. Key Words:rhinosinusitis; chronic rhinosinusitis; acute rhinosinusitis; recurrent acute rhinosinusitis; evidence-based medicine; systematic review; endoscopic sinus surgery List of Abbreviations Used

show abstract

Section: Discussionmentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

557

888

View full text Add to dashboard Cite

show abstract

“…Surprisingly little is known about clinical entities that present with a low IgE result. Low serum IgE has been associated clinically with chronic fatigue and polyarthralgias [8] and a higher prevalence of autoimmune and oncological diseases and asthma, as well as chronic sinusitis and otitis media [9]. Recent studies found an association between low serum IgE levels and the levels of one or more classes of immunoglobulins (i.e.…”

Section: Introductionmentioning

confidence: 99%

Low immunoglobulin E flags two distinct types of immune dysregulation

Elkuch

Greiff

Berger

et al. 2017

Clinical and Experimental Immunology

View full text Add to dashboard Cite

1These authors contributed equally to this study. SummaryDuring the last two decades, hyper-immunoglobulin (Ig)E syndromes have been characterized clinically and molecularly in patients with genetically determined primary immunodeficiencies. However, the detection of low IgE levels, defined here as below detection limit in the routine clinical immunology laboratory, has received little attention. We analysed the association of serum IgA, IgM and IgG levels (including IgG subclasses) with low, normal or high serum IgE levels in patients evaluated in a singlecentre out-patient immunodeficiency and allergy clinic. The correlation of serum IgE levels with IgG subclasses depended on the clinical phenotype. In patients with immunodeficiencies, IgE correlated with IgG2 and IgG4 but not with IgG3. In contrast, in patients referred for signs of allergy, IgE correlated with IgG3 but not with IgG2. A low IgE result was associated with low IgG3 and IgG4 in allergy referrals, while immunodeficiency referrals with a low IgE result had significantly lower IgG1, IgG2 and IgG4 levels. Hierarchical clustering of non-IgE immunoglobulin profiles (IgM, IgA, IgG, IgG1-4) validated that non-IgE immunoglobulin levels predict the clinic referral, i.e. phenotype, of low-IgE patients. These results suggesto guide the clinical management of patients with low serum IgE levels.

show abstract

“…4 Recently, we described a relatively large group of patients with undetectable serum total IgE and found that IgE less than or equal to 2 kIU/L may serve as a marker of immune dysregulation and autoimmunity. 5 IgE is thought to be potentially atherogenic through its proinflammatory influence on mast cells and platelets. 6,7 Likewise, allergic inflammation can promote arterial cell apoptosis and atherogenesis.…”

mentioning

confidence: 99%