Selective impairment of attention networks in breast cancer patients receiving chemotherapy treatment

Chen, Xingui; Li, Jingjing; Ren, Jing; Hu, Xinglong; Zhu, Chunyan; Tian, Yanghua; Hu, Panpan; Ma, Hu; Yu, Fang; Wang, Kai

doi:10.1002/pon.3539

Cited by 27 publications

(22 citation statements)

References 47 publications

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“…The intact orienting attention function found in HIV-infected patients is not unique. Using ANT, we have also found that an intact orienting attentional ability in patients with depression [38], untreated hyperthyroidism [39], and the breast cancer patients receiving chemotherapy treatment [40]. Previous studies have documented that cholinergic systems arising in the basal forebrain appear to play a critical role in orienting attention network [18, 41, 42].…”

Section: Discussionmentioning

confidence: 99%

Selective impairments of alerting and executive control in HIV-infected patients: evidence from attention network test

et al. 2017

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BackgroundAttention ability can be subdivided into three functionally independent networks, i.e., alerting network, orienting network, and executive network. Previous literature has documented that deficits in attention are a common consequence of HIV infection. However, the precise nature of deficits of attention in HIV-infected patients is poorly understood. Accordingly, the aim of the study was to identify whether the HIV-infected patients showed a specific attention network deficit or a general attentional impairment.MethodsWe investigated 27 HIV-infected patients and 31 normal controls with the Attention Network Test (ANT).ResultsThe patients exhibited less efficient alerting network and executive network than controls. No significant difference was found in orienting network effect between groups. Our results also indicate a tendency for poorer efficiency on alerting attention and executive attention in patients with CD4 ≤ 200.ConclusionsOur findings suggest that HIV-infected patients exhibited selective impairments of attention network of alerting and executive control. The link between lower CD4 T cell count and poorer attention network function imply the importance of starting antiretroviral therapy earlier to avoid irreversible neurocognitive impairment.

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Section: Discussionmentioning

confidence: 99%

Selective impairments of alerting and executive control in HIV-infected patients: evidence from attention network test

et al. 2017

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“…In 2002, Posner and Fan designed a simple computer-based paradigm-Attention Network Test (ANT; Fan et al, 2002) to measure the three network efficiencies of attention. Some studies that have applied ANT to patients with focal frontal and parietal lesions (Hu et al, 2013) and breast cancer (Chen et al, 2014) have confirmed that ANT is reliable.…”

Section: Introductionmentioning

confidence: 94%

“…Cerebral small vessel disease (CSVD) refers to the clinical, cognitive, imaging, and pathological manifestations of cerebrovascular syndrome caused by small vessel arteries, arterioles, capillary, and venule change (Chen et al, 2019). The major imaging features of CSVD mainly include white matter hyperintensities (WMHs), enlarged perivascular space (EPVS), cerebral microbleeds (CMBs), and lacunar infarcts (LI;French et al, 2014). The clinical manifestations of CSVD include a wide range of symptoms, which are as follows: typical stroke symptoms, varying degrees of cognitive impairment from mild impairment to dementia (Meissner, 2016).…”

Section: Introductionmentioning

confidence: 99%

Laterality of Attentional Networks in Patients With Cerebral Small Vessel Disease

Cao

Zhang

Wang

et al. 2020

Front. Aging Neurosci.

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Introduction: Problems with attention are common in patients with cerebral small vessel disease (CSVD). The normal human brain exhibits functional and structural asymmetry. However, it is unknown whether there is lateralization of attention in patients with CSVD. Objective: This study aims to investigate attention separately in both cerebral hemispheres in patients with CSVD using the computer-based Lateralized Attention Network Test-Revised (LANT-R). Methods: The total number of subjects included was 58, which includes the CSVD (N = 35) and healthy control (HC, N = 23) groups. All subjects completed the LANT-R paradigm and neuropsychological background tests. Results: The results indicate that there is an left hemisphere (LH) lateralization in orienting network efficiency in the HC group. However, this lateralization was not apparent in the CSVD group. Furthermore, the difference between groups was significant (interaction P = 0.02). In addition, the scores of subjects in the CSVD group are lower in several cognitive domains, including attention function, memory function, information processing speed, and executive function, compared with the controls. Conclusion: Patients with CSVD change in the lateralization of attention compared with the normal elderly. The decrease in attention in patients with CSVD might be caused by the reduced ability of selecting useful information in the LH.

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“…Prior research suggests the effects of CT on specific domains of executive functioning. These findings suggest that CT-treated patients are vulnerable to cognitive control and monitoring (Chen et al, 2014;Yao, Bernstein, & Rich, 2017). Deficits in executive functioning may not have Fig.…”

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confidence: 91%

Heterogeneous Response of Chemotherapy-Related Cognitive Decline in Patients with Breast Cancer: A Prospective Study

Schrauwen

Cavey

Vingerhoets

et al. 2020

J Int Neuropsychol Soc

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Objective: A significant proportion of adjuvant-treated breast cancer patients experience cognitive decline, challenging the person’s ability to return to normal activities after treatment. However, not every patient experiences cognitive problems, and even in patients with impairments, determining clinically important cognitive decline remains challenging. Our objective was to explore differences in neuropsychological performance following adjuvant chemotherapy (CT) in patients with breast cancer. Method: We conducted a prospective observational study in an Oncology Breast Clinic and assessed neuropsychological performance before and after adjuvant CT and in non-CT-treated women with breast cancer and healthy controls (HCs). Standardised between-group differences and regression-based change scores were calculated. Results: CT-treated patients (n = 66) performed significantly different from non-CT-treated patients (n = 39) and HCs (n = 56). There was a significant effect on verbal fluency (p = .0013). CT performed significantly worse than non-CT and HC [effect size (ES) = .89, p < .001 and ES = .61, p ≤ .001, respectively] and from HCs with regard to proactive interference (ES = .62, p ≤ .001). Regression-based scores revealed more severe cognitive decline in the CT-treated group [24.24% (16/66)] than in the non-CT-treated group [15.20% (6/39)] and HC group [7.14% (4/56)]. Patients who underwent CT and showed cognitive decline were less educated and older, with significantly lower baseline scores. Conclusions: CT-treated patients showed more vulnerability on cognitive control and monitoring than non-CT-treated breast cancer patients and HCs. Older patients with less education and lower baseline cognitive performance represent a group at risk for cognitive decline following CT. Identification of patients at risk for decline could improve targeted support and rehabilitation.

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Selective impairment of attention networks in breast cancer patients receiving chemotherapy treatment

Abstract: These results suggest that the three attention networks were selectively impaired following chemotherapy treatment, which affected different brain areas in the breast cancer survivors.

Cited by 27 publications

References 47 publications

Selective impairments of alerting and executive control in HIV-infected patients: evidence from attention network test

Selective impairments of alerting and executive control in HIV-infected patients: evidence from attention network test

Laterality of Attentional Networks in Patients With Cerebral Small Vessel Disease

Heterogeneous Response of Chemotherapy-Related Cognitive Decline in Patients with Breast Cancer: A Prospective Study

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