Selective Impairment of Spatial Cognition Caused by Autoantibodies to the N-Methyl-d-Aspartate Receptor

Chang, Eric H.; Volpe, Bruce T.; Mackay, Meggan; Aranow, Cynthia; Watson, Phillip; Kowal, Czeslawa; Storbeck, Justin; Mattis, Paul J.; Berlin, RoseAnn; Chen, Huiyi; Mader, Simone; Huerta, T.; Huerta, Patricio T.; Diamond, Betty

doi:10.1016/j.ebiom.2015.05.027

Cited by 73 publications

(115 citation statements)

References 38 publications

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“…Peripheral antibodies, released during the disease and targeting the brain glutamatergic system, have been directly implicated in brain derangements (188–191). This insight suggests new therapeutic possibilities.…”

Section: The Role Of the Central Nervous Systemmentioning

confidence: 99%

Molecular and Functional Neuroscience in Immunity

Pavlov

Chavan

Tracey

2018

Annu. Rev. Immunol.

345

320

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The nervous system regulates immunity and inflammation. The molecular detection of pathogen fragments, cytokines, and other immune molecules by sensory neurons generates immunoregulatory responses through efferent autonomic neuron signaling. The functional organization of this neural control is based on principles of reflex regulation. Reflexes involving the vagus nerve and other nerves have been therapeutically explored in models of inflammatory and autoimmune conditions, and recently in clinical settings. The brain integrates neuro-immune communication, and brain function is altered in diseases characterized by peripheral immune dysregulation and inflammation. Here we review the anatomical and molecular basis of the neural interface with immunity, focusing on peripheral neural control of immune functions and the role of the brain in the model of the immunological homunculus. Clinical advances stemming from this knowledge within the framework of bioelectronic medicine are also briefly outlined.

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Section: The Role Of the Central Nervous Systemmentioning

confidence: 99%

Molecular and Functional Neuroscience in Immunity

Pavlov

Chavan

Tracey

2018

Annu. Rev. Immunol.

345

320

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“…2). Betty Diamond and colleagues have provided important insight into the neurological complications of this autoimmune condition pointing to a mediating role of peripheral antibodies targeting the brain glutamatergic system [144–147]. These findings have provided a rationale for developing new therapeutic modalities.…”

Section: The Remote Immunomodulatory Switches In the Brainmentioning

confidence: 99%

Neural circuitry and immunity

2015

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Research during the last decade has significantly advanced our understanding of the molecular mechanisms at the interface between the nervous system and the immune system. Insight into bidirectional neuroimmune communication has characterized the nervous system as an important partner of the immune system in the regulation of inflammation. Neuronal pathways, including the vagus nerve-based inflammatory reflex are physiological regulators of immune function and inflammation. In parallel, neuronal function is altered in conditions characterized by immune dysregulation and inflammation. Here, we review these regulatory mechanisms and describe the neural circuitry modulating immunity. Understanding these mechanisms reveals possibilities to use targeted neuromodulation as a therapeutic approach for inflammatory and autoimmune disorders. These findings and current clinical exploration of neuromodulation in the treatment of inflammatory diseases defines the emerging field of Bioelectronic Medicine.

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“…In the pathophysiology of NPSLE, antidouble stranded (ds)-DNA Ab may contribute to the involvement of the central nervous system. Some anti-native-DNA Ab cross-react with the GluN2A and GluN2B subunits of the N-methyl-D-aspartate (NMDA) receptor for the neurotransmitter glutamate (Chang et al, 2015). Based on mouse experiments, cross-reacting antibodies may contribute to the neurocognitive impairment and other symptoms of NPSLE.…”

Section: Polymorphisms Of the Serotonin Transporter Gene Promoter Regmentioning

confidence: 99%

Depression in Autoimmune Diseases

Pryce

Fontana

2016

Current Topics in Behavioral Neurosciences

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Up to 50% of patients with autoimmune diseases show an impairment of health-related quality of life and exhibit depression-like symptoms. The immune system not only leads to inflammation in affected organs, but also mediates behavior abnormalities including fatigue and depression-like symptoms. This review focuses on the different pathways involved in the communication of the immune system with the neuronal network and the body's timing system. The latter is built up by a hierarchically organized expression of clock genes. As discussed here, the activation of the immune system interferes with high amplitude expression of clock genes, an effect which may play a pivotal role in depression-like behavior in autoimmune diseases.

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Selective Impairment of Spatial Cognition Caused by Autoantibodies to the N-Methyl-d-Aspartate Receptor

Cited by 73 publications

References 38 publications

Molecular and Functional Neuroscience in Immunity

Molecular and Functional Neuroscience in Immunity

Neural circuitry and immunity

Depression in Autoimmune Diseases

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