2005
DOI: 10.1016/j.jacc.2005.03.043
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Selective Increase of Cardiac Neuronal Sympathetic Tone

Abstract: The neural adrenergic tone to the heart can be selectively increased by catheter stimulation of cardiac efferent sympathetic nerves.

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Cited by 15 publications
(7 citation statements)
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“…In ex vivo studies using isolated rabbit and canine hearts, cardiac SNS increased LV pressure by increased contractility [43, 44]. The SNS at the subclavian artery also increased the adrenergic neural tone of the heart [7]. Unfortunately, SNS also significantly increases HR, leading to a significant increase in MVo 2 , the same adverse effect associated with the use of inotropic drugs such as dobutamine to override beta-receptor downregulation and acutely augment LV contractility in patients with acute and endstage HF [45, 46].…”
Section: Cardiac Autonomic Nerve Stimulation Therapymentioning
confidence: 99%
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“…In ex vivo studies using isolated rabbit and canine hearts, cardiac SNS increased LV pressure by increased contractility [43, 44]. The SNS at the subclavian artery also increased the adrenergic neural tone of the heart [7]. Unfortunately, SNS also significantly increases HR, leading to a significant increase in MVo 2 , the same adverse effect associated with the use of inotropic drugs such as dobutamine to override beta-receptor downregulation and acutely augment LV contractility in patients with acute and endstage HF [45, 46].…”
Section: Cardiac Autonomic Nerve Stimulation Therapymentioning
confidence: 99%
“…Future research into the identification of separate cardiac sympathetic neural elements that selectively affect LV contractility over HR may allow sympathetic neuro-modulation in HF therapy. More recent animal studies have investigated the impact of selective SNS by stimulation directly at the heart in isolated heart experiments (ex vivo) and by in vivo deployment of stimulating catheters into the coronary sinus [6, 7]. …”
Section: Cardiac Autonomic Nerve Stimulation Therapymentioning
confidence: 99%
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“…Selective stimulation of the cardiac sympathetic nerves by transvascular stimulation of the heart has been shown [63, 64]. Cardiac sympathetic nerves course within neural sleeves along the subclavian artery.…”
Section: Electrical Stimulation Outside the Heartmentioning
confidence: 99%