Selective induction of apoptosis by ar-turmerone isolated from turmeric (Curcuma longa L) in two human leukemia cell lines, but not in human stomach cancer cell line

Aratanechemuge, Yue; Komiya, Takashi; Moteki, Hiroyuki; Katsuzaki, Hirotaka; Imai, Kunio; Hibasami, Hiroshige

doi:10.3892/ijmm.9.5.481

Cited by 22 publications

(21 citation statements)

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“…Terpenoids are another major class of bioactive compounds found in ginger and turmeric [22,25,36-40]. Isopentenyl diphosphate and dimethylallyl diphosphate (IPP and DMAPP), the common building blocks for mono-, sesqui- and other terpenoids, appear to be produced mainly by the plastidic methylerythritol phosphate (MEP) pathway in these species as ESTs for all enzymes in this pathway were readily identified in the ArREST database at high levels (Additional file 1: Table S4), especially the potential regulatory enzyme, 1-deoxy-D-xylulose-5-phosphate (DOXP) synthase.…”

Section: Resultsmentioning

confidence: 99%

Ginger and turmeric expressed sequence tags identify signature genes for rhizome identity and development and the biosynthesis of curcuminoids, gingerols and terpenoids

Koo

McDowell

et al. 2013

BMC Plant Biol

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BackgroundGinger (Zingiber officinale) and turmeric (Curcuma longa) accumulate important pharmacologically active metabolites at high levels in their rhizomes. Despite their importance, relatively little is known regarding gene expression in the rhizomes of ginger and turmeric.ResultsIn order to identify rhizome-enriched genes and genes encoding specialized metabolism enzymes and pathway regulators, we evaluated an assembled collection of expressed sequence tags (ESTs) from eight different ginger and turmeric tissues. Comparisons to publicly available sorghum rhizome ESTs revealed a total of 777 gene transcripts expressed in ginger/turmeric and sorghum rhizomes but apparently absent from other tissues. The list of rhizome-specific transcripts was enriched for genes associated with regulation of tissue growth, development, and transcription. In particular, transcripts for ethylene response factors and AUX/IAA proteins appeared to accumulate in patterns mirroring results from previous studies regarding rhizome growth responses to exogenous applications of auxin and ethylene. Thus, these genes may play important roles in defining rhizome growth and development. Additional associations were made for ginger and turmeric rhizome-enriched MADS box transcription factors, their putative rhizome-enriched homologs in sorghum, and rhizomatous QTLs in rice. Additionally, analysis of both primary and specialized metabolism genes indicates that ginger and turmeric rhizomes are primarily devoted to the utilization of leaf supplied sucrose for the production and/or storage of specialized metabolites associated with the phenylpropanoid pathway and putative type III polyketide synthase gene products. This finding reinforces earlier hypotheses predicting roles of this enzyme class in the production of curcuminoids and gingerols.ConclusionA significant set of genes were found to be exclusively or preferentially expressed in the rhizome of ginger and turmeric. Specific transcription factors and other regulatory genes were found that were common to the two species and that are excellent candidates for involvement in rhizome growth, differentiation and development. Large classes of enzymes involved in specialized metabolism were also found to have apparent tissue-specific expression, suggesting that gene expression itself may play an important role in regulating metabolite production in these plants.

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Section: Resultsmentioning

confidence: 99%

Ginger and turmeric expressed sequence tags identify signature genes for rhizome identity and development and the biosynthesis of curcuminoids, gingerols and terpenoids

Koo

McDowell

et al. 2013

BMC Plant Biol

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“…The anti-invasive effects of curcumin in estrogen receptor-negative MDA-MB-231 cells have been demonstrated by Shao et al (Shao et al, 2002), nevertheless, the suppressive activities of other constituents of CL, such as α-turmerone, on this cell type are worth attention. Besides, apoptosis induced by ar-turmerone in leukemia cells has been reported (Aratanechemuge et al, 2002; Ji et al, 2004). To date, the molecular mechanisms of action of α-turmerone and its effects on breast cancer cells are not fully understood.…”

Section: Discussionmentioning

confidence: 99%

“…Volatile oil isolated from CL had been reported to have antibacterial (Norajit et al, 2007) and antifungal activities (Roth et al, 1998), anti-proliferation in human leukemia (Shi et al, 2003) and lung cancer cells (Wang et al, 2005). Previous studies have shown that aromatic turmerone isolated from CL could induce apoptosis in human leukemia cells (Aratanechemuge et al, 2002) and murine leukemia cells (Ji et al, 2004). The aromatic turmerone also possessed antioxidant (Jayaprakasha et al, 2002) and antiplatelet activities (Lee, 2006).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of in vitro anti-proliferative and immunomodulatory activities of compounds isolated from Curcuma longa

Yue

Chan

Hon

et al. 2010

Food and Chemical Toxicology

133

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The rhizome of Curcuma longa (CL) has been commonly used in Asia as a potential candidate for the treatment of different diseases, including inflammatory disorders and cancers. The present study evaluated the anti-proliferative activities of the isolated compounds (3 curcuminoids and 2 turmerones) from CL, using human cancer cell lines HepG2, MCF-7 and MDA-MB-231. The immunomodulatory activities of turmerones (α and aromatic) isolated from CL were also examined using human peripheral blood mononuclear cells (PBMC). Our results showed that the curcuminoids (curcumin, demethoxycurcumin and bisdemethoxycurcumin) and α-turmerone significantly inhibited proliferation of cancer cells in dose-dependent manner. The IC50 values of these compounds in cancer cells ranged from 11.0–41.8 μg/ml. Alpha-turmerone induced MDA-MB-231 cells to undergo apoptosis, which was confirmed by annexin-V & propidium iodide staining, and DNA fragmentation assay. The caspase cascade was activated as shown by a significant decrease of procaspases-3, -8 and -9 in α-turmerone treated cells. Both α-turmerone and aromatic-turmerone showed stimulatory effects on PBMC proliferation and cytokine production. The anti-proliferative effect of α-turmerone and immunomodulatory activities of ar-turmerone were shown for the first time. The findings revealed the potential use of CL crude extract (containing curcuminoids and volatile oil including turmerones) as chemopreventive agent.

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“…Both sesamin and episesamin (an epimer of sesamin) induce apoptosis in human lymphoid leukemia cells in vitro , as demonstrated by such morphological changes as apoptotic bodies (196). Both sesamolin and turmerone induce apoptosis in human leukemia cells seen by DNA fragmentation into oligonucleosomal-sized fragments (197). …”

Section: Introductionmentioning

confidence: 99%

Molecular Targets of Nutraceuticals Derived from Dietary Spices: Potential Role in Suppression of Inflammation and Tumorigenesis

Aggarwal

Kuiken

Iyer

et al. 2009

Exp Biol Med (Maywood)

179

149

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Despite the fact cancer is primarily a preventable disease, recent statistics indicate cancer will become the number one killer worldwide in 2010. Since certain cancers are more prevalent in the people of some countries than others, suggests the role of lifestyle. For instance cancer incidence among people from the Indian subcontinent, where most spices are consumed, is much lower than that in the Western World. Spices have been consumed for centuries for a variety of purposes—as flavoring agents, colorants, and preservatives. However, there is increasing evidence for the importance of plant-based foods in regular diet to lowering the risk of most chronic diseases, so spices are now emerging as more than just flavor aids, but as agents that can not only prevent but may even treat disease. In this article, we discuss the role of 41 common dietary spices with over 182 spice-derived nutraceuticals for their effects against different stages of tumorigenesis. Besides suppressing inflammatory pathways, spice-derived nutraceuticals can suppress survival, proliferation, invasion, and angiogenesis of tumor cells. We discuss how spice-derived nutraceuticals mediate such diverse effects and what their molecular targets are. Overall our review suggests “adding spice to your life” may serve as a healthy and delicious way to ward off cancer and other chronic diseases.

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Selective induction of apoptosis by ar-turmerone isolated from turmeric (Curcuma longa L) in two human leukemia cell lines, but not in human stomach cancer cell line

Cited by 22 publications

References 0 publications

Ginger and turmeric expressed sequence tags identify signature genes for rhizome identity and development and the biosynthesis of curcuminoids, gingerols and terpenoids

Ginger and turmeric expressed sequence tags identify signature genes for rhizome identity and development and the biosynthesis of curcuminoids, gingerols and terpenoids

Evaluation of in vitro anti-proliferative and immunomodulatory activities of compounds isolated from Curcuma longa

Molecular Targets of Nutraceuticals Derived from Dietary Spices: Potential Role in Suppression of Inflammation and Tumorigenesis

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