Selective induction of B7/BB-1 on interferon-γ stimulated monocytes: A potential mechanism for amplification of T cell activation through the CD28 pathway

Freedman, Arnold S.; Freeman, Gordon J.; Rhynhart, Kurt K.; Nadler, Lee M.

doi:10.1016/0008-8749(91)90091-o

Cited by 300 publications

(154 citation statements)

References 41 publications

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“…CD28 is expressed by naïve T cells and supplies a coactivation signal for cell growth (46,47). This receptor binds B7-1 (CD80) and B7-2 (CD86) on APCs (48), and as more recently shown, B7-H1 (49).…”

Section: Discussionmentioning

confidence: 99%

RANTES Potentiates Antigen-Specific Mucosal Immune Responses

Lillard

Boyaka

Taub

et al. 2001

The Journal of Immunology

106

105

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RANTES is produced by lymphoid and epithelial cells of the mucosa in response to various external stimuli and is chemotactic for lymphocytes. The role of RANTES in adaptive mucosal immunity has not been studied. To better elucidate the role of this chemokine, we have characterized the effects of RANTES on mucosal and systemic immune responses to nasally coadministered OVA. RANTES enhanced Ag-specific serum Ab responses, inducing predominately anti-OVA IgG2a and IgG3 followed by IgG1 and IgG2b subclass Ab responses. RANTES also increased Ag-specific Ab titers in mucosal secretions and these Ab responses were associated with increased numbers of Ab-forming cells, derived from mucosal and systemic compartments. Splenic and mucosally derived CD4+ T cells of RANTES-treated mice displayed higher Ag-specific proliferative responses and IFN-γ, IL-2, IL-5, and IL-6 production than control groups receiving OVA alone. In vitro, RANTES up-regulated the expression of CD28, CD40 ligand, and IL-12R by Ag-activated primary T cells from DO11.10 (OVA-specific TCR-transgenic) mice and by resting T cells in a dose-dependent fashion. These studies suggest that RANTES can enhance mucosal and systemic humoral Ab responses through help provided by Th1- and select Th2-type cytokines as well as through the induction of costimulatory molecule and cytokine receptor expression on T lymphocytes. These effects could serve as a link between the initial innate signals of the host and the adaptive immune system.

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Section: Discussionmentioning

confidence: 99%

RANTES Potentiates Antigen-Specific Mucosal Immune Responses

Lillard

Boyaka

Taub

et al. 2001

The Journal of Immunology

106

105

View full text Add to dashboard Cite

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“…B7 is not expressed on resting B cells (19) but appears following crosslinking of surface Ig (10,19) or class II MHC (9) . Moreover, B7 is not expressed on unstimulated monorytes and is specifically induced by INF-y but not other stimuli which activate monocytes (20). Human B7 (hB7) 1 transfected cells or recombinant B7-Ig fusion protein augment proliferation and induce IL2, but not IIT4, synthesis in T cells which have been treated with phorbol ester or anti-CD3 mAb (7-9) .…”

Section: Discussionmentioning

confidence: 99%

Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7.

Freeman

Gray

Gimmi

et al. 1991

The Journal of Experimental Medicine

326

146

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SummaryFollowing occupancy of the T cell receptor by antigen, T cell proliferation and lymphokine production are determined by a second costimulatory signal delivered by a ligand expressed on antigen presenting cells. The human B cell activation antigen B7, which is expressed on antigen presenting cells including activated B cells and 'Y interferon treated monorytes, has been shown to deliver such a costimulatory signal upon attachment to its ligand on T cells, CD28. We have cloned and sequenced the murine homologue of the human B7 gene . The predicted murine protein has 44% amino acid identity with human B7 . The greatest similarity is in the IgV and Ig-C like domains . Murine B7 mRNA was detected in murine hematopoietic cells of B cell but not T cell origin . Cells transfected with murine B7 provided a costimulatory signal to human CD28+ T lymphocytes. These results demonstrate the costimulatory activity of murine B7 and provide evidence that the ligand attachment site is conserved between the two species .Although occupancy of the TCR complex by antigen in 13, association with the MHC is necessary for the initiation of T cell activation, several lines of evidence suggest that a second costimulatory signal is essential for the induction of proliferation and lymphokine secretion (1-4) . In murine and human systems, this costimulatory signal is delivered by APC and requires cell to cell contact (2, 4) . Cells which can deliver this costimulatory signal include activated, but not resting B lymphocytes (5), INF-y activated monorytes, and dendritic cells (2, 6) .Several recent studies in human systems have provided compelling evidence that the B cell activation antigen B7 can provide one such costimulatory signal (7-9) . B7, a member of the Ig supergene family, has been shown to be a ligand for another member of this family, the T cell surface protein CD28, (10-13) . CD28 is constitutively expressed on 95% of human CD4+ T cells, 50% of CD8+ T cells, and on thymocytes which coexpress CD4 and CD8 (14-16) . Following suboptimal activation of T cells with anti-CD3 mAb (16), anti-CD2 mAb, or phorbol ester (17), crosslinking of CD28 by anti-CD28 mAb results in enhanced T cell proliferation and greatly augments synthesis of multiple lymphokines (18). B7 is likely to be an important regulator of T cell proliferation and lymphokine production as evidenced by its pattern of expression and functional activity. B7 is not expressed on resting B cells (19) but appears following crosslinking of surface Ig (10, 19) or class II MHC (9) . Moreover, B7 is not expressed on unstimulated monorytes and is specifically induced by INF-y but not other stimuli which activate monocytes (20). Human B7 (hB7) 1 transfected cells or recombinant B7-Ig fusion protein augment proliferation and induce IL2, but not IIT4, synthesis in T cells which have been treated with phorbol ester or anti-CD3 mAb (7-9) .In murine systems, a homologue for CD28 has recently been cloned (21); however, a conserved functional activity has not yet been demonstrated . In ...

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“…In the majority of tumors analyzed, factor kemia cell line with IFN␥ also leads to increased B7-1 expression. 76,78 In contrast, two other groups have demonindependence appeared to have been achieved by autocrine GM-CSF production. Results obtained from this system supstrated differential up-regulation of B7-2 and down-regulation of B7-1 consequent to IFN␥ stimulation in peritoneal macroport our earlier observations in which irradiated syngeneic or GMT mice received factor-dependent, FDC-P1 cells.…”

Section: Dendritic Cell Features Of Igm36 Cellsmentioning

confidence: 99%

Establishment of multipotential and antigen presenting cell lines derived from myeloid leukemias in GM-CSF transgenic mice

et al. 1997

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In this study neonatal mice expressing a GM-CSF transgeneanalyses of most human myeloid leukemias at diagnosis (GMT mice), and their normal littermate controls, were infected reveal that they remain growth factor-dependent and responwith Moloney murine leukemia virus (MoMLV) to examine in sive to a number of cytokines at typical concentrations. [15][16][17][18] vivo tumorigenesis. By 200 days, all of the GMT mice had died Therefore GM-CSF (and other cytokines) may be an essential whereas median survival had not been reached in the litco-factor either contributing to the in vivo expansion of the termates (P Ͻ 0.0003). Thymomas developed in 32% of GMT mice and were more frequently CD4 ؉ CD8 ؉ (83%) compared to transformed myeloid clone itself or amplifying the number of the CD4 ؉ CD8 ؊ phenotype seen in 90% of thymomas developing partially transformed cells as targets for further mutations. The experiments reported here were undertaken to deter-

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Selective induction of B7/BB-1 on interferon-γ stimulated monocytes: A potential mechanism for amplification of T cell activation through the CD28 pathway

Cited by 300 publications

References 41 publications

RANTES Potentiates Antigen-Specific Mucosal Immune Responses

RANTES Potentiates Antigen-Specific Mucosal Immune Responses

Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7.

Establishment of multipotential and antigen presenting cell lines derived from myeloid leukemias in GM-CSF transgenic mice

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