Selective induction of IL-1β after a brief isoflurane anesthetic in children undergoing MRI examination

Whitaker, Emmett E.; Christofi, Fievos L.; Quinn, Kristen M.; Wiemann, Brianne; Xia, Jason C; Tobias, Joseph D.; Bissonnette, Bruno

doi:10.1007/s00540-016-2294-y

Cited by 19 publications

(11 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, in C5aR2 −/− mice, the concentrations of IL-1β, tumour necrosis factor (TNF) α and monocyte chemoattractant protein-1 (MCP-1) were significantly elevated after isolated fracture, indicating a pulmonary inflammatory response after bone fracture even in the absence of thoracic trauma. Moreover, MCP-1 was increased in BAL fluid of C5aR2 −/− mice without any injury, presumably because of general anaesthesia with isoflurane, which could induce an inflammatory response 22 , 23 .…”

Section: Resultsmentioning

confidence: 98%

Complement receptors C5aR1 and C5aR2 act differentially during the early immune response after bone fracture but are similarly involved in bone repair

Kovtun

Bergdolt

Hägele

et al. 2017

Sci Rep

View full text Add to dashboard Cite

Severely injured patients frequently suffer compromised fracture healing because of systemic post-traumatic inflammation. An important trigger of the posttraumatic immune response is the complement anaphylatoxin C5a, which acts via two receptors, C5aR1 and C5aR2, expressed on immune and bone cells. The blockade of C5a-mediated inflammation during the early inflammatory phase was demonstrated to improve fracture healing after severe injury. However, the distinct roles of the two complement receptors C5aR1 and C5aR2 in bone has to date not been studied. Here, we investigated bone turnover and regeneration in mice lacking either C5aR1 or C5aR2 in a model of isolated fracture and after severe injury, combining the fracture with an additional thoracic trauma. Both C5aR1−/− and C5aR2−/− mice displayed an increased bone mass compared to wild-type controls due to reduced osteoclast formation and increased osteoblast numbers, respectively. Following fracture, the inflammatory response was differently affected in these strains: It was decreased in C5aR1−/− mice but enhanced in C5aR2−/− mice. Both strains exhibited impaired fracture healing, disturbed osteoclastogenesis and delayed cartilage-to-bone transformation. Thus, our data suggest that C5aR1 and C5aR2 differentially regulate the immune response after fracture and are required for effective cartilage-to-bone transformation in the fracture callus and for undisturbed bone healing.

show abstract

Section: Resultsmentioning

confidence: 98%

Complement receptors C5aR1 and C5aR2 act differentially during the early immune response after bone fracture but are similarly involved in bone repair

Kovtun

Bergdolt

Hägele

et al. 2017

Sci Rep

View full text Add to dashboard Cite

show abstract

“…The mean physiological blood levels are relatively lower than those in the present study because the operation caused pain. The mean plasma IL-6 and IL-1β levels in patients who experience only narcosis are 2.04 and 38.53 pg/ml, respectively [ 18 , 40 ]. According to these values, the mean blood level of IL-6 is lower and the mean level of IL-1β is higher than the levels in the two groups from the present study.…”

Section: Discussionmentioning

confidence: 99%

Dexmedetomidine combined with suprascapular nerve block and axillary nerve block has a synergistic effect on relieving postoperative pain after arthroscopic rotator cuff repair

Lee

Kim

Hwang

et al. 2020

Knee Surg Sports Traumatol Arthrosc

View full text Add to dashboard Cite

Purpose Suprascapular nerve block (SSNB) is the most commonly used block for the relief of postoperative pain from arthroscopic rotator cuff repair and can be used in combination with axillary nerve block (ANB). Dexmedetomidine (DEX) is a type of alpha agonist that can elongate the duration of regional block. The aim of this study was to compare the effects of the use of dexmedetomidine combined with SSNB and ANB with those of the use of SSNB and ANB alone on postoperative pain, satisfaction, and pain-related cytokines within the first 48 h after arthroscopic rotator cuff repair. Methods Forty patients with rotator cuff tears who had undergone arthroscopic rotator cuff repair were enrolled in this single-center, double-blinded randomized controlled trial study. Twenty patients were randomly allocated to group 1 and received ultrasound-guided SSNB and ANB using a mixture of 0.5 ml (50 μg) of DEX and 9.5 ml of 0.75% ropivacaine preemptively. The other 20 patients were allocated to group 2 and underwent ultrasound-guided SSNB and ANB alone using a mixture of 0.5 ml of normal saline and 9.5 ml of ropivacaine. The visual analog scale (VAS) for pain and patient satisfaction (SAT) scores were postoperatively checked within 48 h. The plasma interleukin (IL)-6, IL-8, IL-1β, cortisol, and serotonin levels were also postoperatively measured within 48 h. Results Group 1 showed a significantly lower mean VAS (visual analog scale of pain) score 1, 3, 6, 12, 18 and 24 h after operation, and a significantly higher mean SAT (patient satisfaction) score 1, 3, 6, 12, 18, 24 and 36 h after the operation than group 2. Group 1 showed a significantly lower mean plasma IL-8 level 1 and 48 h after the operation, and a significantly lower mean IL-1β level 48 h after the operation than group 2. Group 1 showed a significantly lower mean plasma serotonin level 12 h after the operation than group 2. The mean timing of rebound pain in group 1 was significantly later than that in group 2 (36 h > 23 h, p = 0.007). Six patients each in groups 1 and 2 showed rebound pain. The others did not show rebound pain. Conclusions Ultrasound-guided SSNA and ANB with DEX during arthroscopic rotator cuff repair resulted in a significantly lower mean VAS score and a significantly higher mean SAT score within 48 h after the operation than SSNB and ANB alone. Additionally, SSNB and ANB with DEX tended to result in a later mean timing of rebound pain accompanied by significant changes in IL-8, IL-1β, and serotonin levels within 48 h after the operation. The present study could provide the basis for selecting objective parameters of postoperative pain in deciding the optimal use of medication for relieving pain. Level of Evidence Level I. Trial Registration 2015–20, ClinicalTrials.gov Identifier: NCT04398589. IRB number 2015–20, Hallym University Chunc...

show abstract

“…Следовательно, локальная активация NF-kB -это предполагаемый механизм изофлю-ран -индуцированного нейровоспаления за счет повышения продукции провоспалительных цито-кинов [15]. Недавнее исследование уровней прово-спалительных и противовоспалительных цитокинов у детей в возрасте от 6 месяцев до 11 лет, которым без хирургического вмешательства выполнялась магнитно-резонансная томография с диагностиче-ской целью в условиях общей анестезии изофлю-раном с помощью ларингеальной маски, показало, что статистически значимым было существенное повышение уровней IL1β [16], указывающее на из-бирательную активацию иммунного ответа у детей в условиях общей анестезии изофлюраном.…”

Section: изофлюранunclassified

The Role of General Anesthetics in Modulation of the Systemic Inflammation Response During Perioperative Period

Savvina¹,

Kostareva²,

Федоров³

et al. 2017

Transl. med. (Print)

View full text Add to dashboard Cite

РезюмеОбщие анестетики оказывают воздействие на иммунную систему. Такая иммуномодуляция может иметь как отрицательный, так и положительный эффект на исход хирургического вмешательства и отдаленные результаты лечения. Публикация посвящена обсуждению и систематизации данных о нарушении регуляции иммунной системы в периоперационном периоде, эффектах некоторых наиболее распространенных препаратов для анестезии на клетки иммунной системы и цитокины, а также возможные клинические проявления иммуномодуляции при использовании общих анестетиков. AbstractGeneral anesthetics affect the immune system. Such immunomodulation can have both a negative and a positive effect on the outcome of surgical intervention and distant treatment results. Current review is devoted to the discussion and systematization of data on deregulation of the immune system in the perioperative period, the effects of some of the most common anesthetics on the immune cells and cytokines, as well as possible clinical manifestations of immunomodulation using general anesthetics.

show abstract

Selective induction of IL-1β after a brief isoflurane anesthetic in children undergoing MRI examination

Abstract: A brief (approximately 60 min) exposure to isoflurane general anesthesia, without induced surgical stress, significantly increased serum IL-1β, a selective activation marker of systemic inflammation (IL-1β pathway).

Cited by 19 publications

References 38 publications

Complement receptors C5aR1 and C5aR2 act differentially during the early immune response after bone fracture but are similarly involved in bone repair

Complement receptors C5aR1 and C5aR2 act differentially during the early immune response after bone fracture but are similarly involved in bone repair

Dexmedetomidine combined with suprascapular nerve block and axillary nerve block has a synergistic effect on relieving postoperative pain after arthroscopic rotator cuff repair

The Role of General Anesthetics in Modulation of the Systemic Inflammation Response During Perioperative Period

Contact Info

Product

Resources

About