Selective inhibition of arthropod-borne and arenaviruses in vitro by 3′-fluoro-3′-deoxyadenosine

Nucleoside Inhibitors of Tick-Borne Encephalitis Virus

“…Regarding flaviviruses, nucleoside analogues have been demonstrated to be efficacious in HCV replicon assays (12)(13)(14)(15)(16) and also against DENV (17)(18)(19)(20)(21), WNV (22), and YFV (23). Some of them were described as broad-spectrum inhibitors of various RNA viruses (24)(25)(26)(27). 2=-Modified nucleoside analogues exhibit a high antiflavivirus activity and good pharmacokinetic properties (9).…”

Biodistribution and PET imaging of [18F]-fluoroadenosine derivatives

“…These two new radiotracers have been tested in tumor-bearing nude mice in order to identify them as potential PET imaging agents for tumor proliferation and/or viral gene expression. Since fluorinated analogues of adenosine, particularly, the 3′-deoxy-3′-fluoro-ribo compounds have shown antiviral activity [9][10][11], we have evaluated both compounds in human colon cancer xenografts produced by inoculation of wild type cells and stably transduced cell with HSV1-tk gene in nude mice. The data generated from this study suggests that none of these compounds are substrate for HSV-tk gene, on the other hand, one compound appears to be a marker for tumor proliferation and the other compound may be a heart imaging agent.…”

“…Many fluorinated analogues of adenosine nucleoside have been synthesized and studied as potential antitumor and antiviral agents [1][2][3][4][5][6][7][8][9][10][11]. Among these, 2′-deoxy-2′-fluoro-2-chloro-9β-D-arabinofuranosyl-adenine has been found to be active against human colon tumor xenografts [6,7].…”

“…Among these, 2′-deoxy-2′-fluoro-2-chloro-9β-D-arabinofuranosyl-adenine has been found to be active against human colon tumor xenografts [6,7]. The 2′-deoxy-2′-fluoro-arabino compounds gained much attention as anticancer agents [6][7][8], and the 3′-deoxy-3′-fluoro-ribo compounds have shown antiviral activity [9][10][11]. However, little information is available regarding the biological properties of the xylo-derivative, 3′-fluoro-9-β-D-xylofuranosyl-adenine [1,12,13].…”

Effects of Monoclonal Antibody Combined with Ganciclovir or <i>(S</i><i>)</i>-1-[3-Hydroxy-(2-phosphonylmethoxy)-propyl]cytosine against Murine Cytomegalovirus Infections in Cell Culture and in Severe Combined Immunodeficient Mice

“…After 4 h, varying con centrations of antibody and/or drug were added in me dium containing 10% scrum. After 4 days, the cells were enumerated using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay de scribed previously [24]. This required transfer of 100 pi of the MTT formazen product from each well to a 96-well plate in order to be quantified by an ELISA plate reader (at 600 nm wavelength).…”