Selective inhibition of pinacidil effects by estrogen in guinea pig heart

Kocić, Ivan; Gruchała, Marta; Petrusewicz, Jacek

doi:10.1016/j.ijcard.2005.06.033

Cited by 6 publications

(5 citation statements)

References 15 publications

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“…[36, 37] Antiarrhythmic drugs that prolong the QT interval increase risk for torsade-de-pointes in women and was the reason some such drugs were removed from the market. [38] Estrogenic compounds modulate potassium currents in atrial tissue [39, 40], but the relationship between endogenous and exogenous estrogen on incidence of AF in women is not established.…”

Section: The Heartmentioning

confidence: 99%

Sex-Specific Physiology and Cardiovascular Disease

Shufelt

Pacheco

et al. 2018

Advances in Experimental Medicine and Biology

119

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Sex differences in cardiovascular diseases can be classified as those which are specific to one sex and those that differ in incidence, prevalence, etiology, symptomatology, response to treatment, morbidity, and mortality in one sex compared to the other. All sex differences in cardiovascular conditions have their basis in the combined expression of genetic and hormonal differences between women and men. This chapter addresses how understanding basic mechanisms of hormone responses, imaging diagnostics, and integration of genomics and proteomics has advanced diagnosis and improved outcomes for cardiovascular conditions, apart from those related to pregnancy that are more prevalent in women. These conditions include obstructive coronary artery disease, coronary microvascular dysfunction, spontaneous coronary artery dissection, diseases of the cardiac muscle including heart failure and takotsubo cardiomyopathy, and conditions related to neurovascular dysregulation including hot flashes and night sweats associated with menopause and effects of exogenous hormones on vascular function. Improvement in technologies allowing for noninvasive assessment of neuronally mediated vascular reactivity will further improve our understanding of the basic etiology of the neurovascular disorders. Consideration of sex, hormonal status, and pregnancy history in diagnosis and treatment protocols will improve prevention and outcomes of cardiovascular disease in women as they age.

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Section: The Heartmentioning

confidence: 99%

Sex-Specific Physiology and Cardiovascular Disease

Shufelt

Pacheco

et al. 2018

Advances in Experimental Medicine and Biology

119

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“…It has been suggested that estrogen changes the modulation of the sarcK ATP channel binding site for pinacidil. 39 If this is true for rat ventricular myocytes, estrogen may prevent the modulation of sarcK ATP channels in female rats that have been given pinacidil.…”

Section: The Effect Of K Atp Channel Modulators On I/r-induced Arrhythmias In Femalesmentioning

confidence: 99%

Both Mitochondrial KATP Channel Opening and Sarcolemmal KATP Channel Blockage Confer Protection Against Ischemia/Reperfusion-Induced Arrhythmia in Anesthetized Male Rats

Gonca

Bozdoğan

2010

J Cardiovasc Pharmacol Ther

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results of the current study indicate that both mitochondrial K(ATP) channel activation and sarcolemmal K(ATP) channel inhibition exert antiarrhythmic action in male rats. The antiarrhythmic effect of pinacidil is not depend on the sarcolemmal K(ATP) channel opening. These results also indicate that K(ATP) channel modulators show no discernable effect in female rats due to the already low incidence of arrhythmias in females.

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“…It could be explanation for recently demonstrated increase in mortality due to cardiovascular events in postmenopausal women treated by hormone replacement therapy [13]. Therefore, apart from recently published data about estrogen effects on the function of ATP-sensitive K + channels [24], here we presented additional data about an important action of estrogen on the β-adrenoceptors in the heart, which are crucial for the regulation of heart work during ischaemia.…”

Section: Discussionmentioning

confidence: 85%