1986
DOI: 10.1182/blood.v67.6.1631.bloodjournal6761631
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Selective inhibition of the growth of human erythroid bursts by monoclonal antibodies against transferrin or the transferrin receptor

Abstract: The relative requirements of colonies derived from erythroid (BFU-E) and myeloid (CFU-c) progenitors for transferrin were examined using monoclonal antibodies directed against the transferrin molecule (TF-6) or its cell surface receptor (TFR-A12, TFR1–2B). Growth of erythroid bursts was profoundly reduced at concentrations of all three antibodies that had no effect on CFU-c-derived colonies. When TFR1–2B was layered over cultures established one to seven days previously, further burst development was inhibited… Show more

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“…Removing Tf or iron from the medium causes reduced cell growth and eventual cell death. These observations indicate that in mononuclear cells TfR expression is associated with cell activation, growth control and cell proliferation (Cook et al, 1993;May & Cuatrecasas, 1985;Teatle, 1990;Hedley et al, 1985;Musgrove et al, 1984;Shannon et al, 1986).…”
mentioning
confidence: 92%
“…Removing Tf or iron from the medium causes reduced cell growth and eventual cell death. These observations indicate that in mononuclear cells TfR expression is associated with cell activation, growth control and cell proliferation (Cook et al, 1993;May & Cuatrecasas, 1985;Teatle, 1990;Hedley et al, 1985;Musgrove et al, 1984;Shannon et al, 1986).…”
mentioning
confidence: 92%