SELECTIVE INHIBITION OF THERMOGENESIS BY TRIBUTYL <i>S,S,S</i>,‐PHOSPHOROTRITHIOATE (DEF)

Ray, David

doi:10.1111/j.1476-5381.1980.tb07898.x

Cited by 10 publications

(1 citation statement)

References 9 publications

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“…However, there remains the possibility that the difference in SIH response was the result of the difference in heat conservation behavior seen during freezing behavior. Piloerection is observed during freezing behavior (Fernandez-Espejo & Mir, 1990) and is known as one of the heat conservation behaviors (Hart, 1988; Ray, 1980). It therefore seems likely that the more the animal shows the freezing behavior, the more its heat is conserved, and thus the more the SIH response is aggravated.…”

Section: Discussionmentioning

confidence: 99%

Partner's Stress Status Influences Social Buffering Effects in Rats.

Kiyokawa¹,

Kikusui²,

Takeuchi³

et al. 2004

Behavioral Neuroscience

150

105

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The relationship between a social partner's stress status and the social buffering effect was examined in adult male Wistar rats. Fear-conditioned rats were exposed to the same context along with either a shocked or nonshocked conspecific partner. Changes in body temperature and behavioral responses were monitored in order to compare the effects of social buffering, and the Fos protein in the paraventricular nucleus was immunostained. The presence of the partner rat attenuated stress-induced hyperthermia, as well as behavioral responses and Fos expression in response to the fearful context, and nonshocked partners were more effective than shocked partners. These findings suggest that the social buffering effect depends on the stress status of the accompanying conspecific animal.

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Section: Discussionmentioning

confidence: 99%

Partner's Stress Status Influences Social Buffering Effects in Rats.

Kiyokawa¹,

Kikusui²,

Takeuchi³

et al. 2004

Behavioral Neuroscience

150

105

View full text Add to dashboard Cite

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Hypothermia produced by tributyl S,S,S-phosphorotrithioate (DEF)

Ray

Cunningham

1985

Arch Toxicol

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Tributyl S,S,S-phosphorotrithioate (DEF) produces profound hypothermia in rats, mice and guinea pigs by inhibition of thermogenesis. Its actions on heat conservation and motor control are, however, minimal. It is effective against both shivering and non-shivering thermogenesis and completely blocks the increase in body temperature evoked by anterior hypothalamic stimulation. A number of other measures indicated that this is unlikely to be due to a lack of peripheral thermogenic capacity: thus plasma concentrations of glucose, free fatty acids, and ketone bodies remained normal or rose after DEF, and in vitro noradrenaline-stimulated lipolysis was normal in the presence of DEF. The metabolic response to the uncoupler, 2,4-dinitrophenol was unchanged by DEF, and the increase in temperature of brown fat evoked in vivo by nerve stimulation or noradrenaline was also unaffected. It is suggested that DEF (or more likely a DEF metabolite) acts selectively on a central thermogenic control process.

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Pleiotropic effect of the gene hairless on hepatotoxicity of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin in mice

Greig¹,

Francis²,

Kay³

et al. 1987

Arch Toxicol

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Treatment of mice of the A2G-hr/+ congenic line with 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) resulted in the development of hepatic porphyria over a period of 4 weeks. Female mice responded to a lesser extent than did males. The degree of porphyria in haired heterozygotes (hr/+) was less than in the corresponding hairless homozygotes (hr/hr) and the haired mice had lower resting metabolic rates than hairless mice. Adaptation of mice of either genotype to a 32-33 degrees C environment resulted in a decrease in resting metabolic rate and a reduction in hepatic porphyrin levels. Histologically-demonstrated necrotic changes in livers were accompanied by increased activity of alanine aminotransferase and sorbitol dehydrogenase in the plasma; however, there was no clear temporal trend in plasma enzyme levels. Elevated environmental temperature reduced the plasma alanine aminotransferase activity. The study provided evidence for a pleiotropic effect of variation at the hr locus being expressed in TCDD hepatotoxicity. Suggestions for mechanisms whereby the effect can be mediated through alterations in resting metabolic rate are made.

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SELECTIVE INHIBITION OF THERMOGENESIS BY TRIBUTYL S,S,S,‐PHOSPHOROTRITHIOATE (DEF)

Cited by 10 publications

References 9 publications

Partner's Stress Status Influences Social Buffering Effects in Rats.

Partner's Stress Status Influences Social Buffering Effects in Rats.

Hypothermia produced by tributyl S,S,S-phosphorotrithioate (DEF)

Pleiotropic effect of the gene hairless on hepatotoxicity of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin in mice

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