2006
DOI: 10.1177/1087057106287933
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Selective Inhibitors of Bacterial DNA Adenine Methyltransferases

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Cited by 52 publications
(51 citation statements)
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References 34 publications
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“…Mutants with deletions of the dam gene lack adenine methylase and are almost uniquely sensitive to TRI. Mashhoon, Reich, and coworkers have identified a number of compounds that specifically inhibit bacterial methylases, including the Dam methylase (58,59). Using these inhibitors in the presence of TRI on the wild-type strain would be equivalent to using a dam mutant strain with TRI and, thus, could be an effective drug combination.…”
Section: Resultsmentioning
confidence: 99%
“…Mutants with deletions of the dam gene lack adenine methylase and are almost uniquely sensitive to TRI. Mashhoon, Reich, and coworkers have identified a number of compounds that specifically inhibit bacterial methylases, including the Dam methylase (58,59). Using these inhibitors in the presence of TRI on the wild-type strain would be equivalent to using a dam mutant strain with TRI and, thus, could be an effective drug combination.…”
Section: Resultsmentioning
confidence: 99%
“…A high-throughput small molecule screen identified several lead compounds including those which appear to bind specifically to the allosteric sites of Dam [72]. Some compounds showed greater than 400-fold selectivity for Dam compared to murine DNA cytosine methyltransferase (Dnmt1).…”
Section: Dna Methyltransferasesmentioning
confidence: 99%
“…This plethora of virulence-related alterations, combined with the long persistence of dam mutants in infected animals, makes Dam-deficient strains highly suitable as live vaccines (13,14,22). On the other hand, the essential role played by Dam methylation in the virulence of Salmonella and other bacterial pathogens (24) has raised the possibility of using Dam inhibitors as antibacterial drugs (34).…”
mentioning
confidence: 99%