2008
DOI: 10.1002/med.20125
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Selective inhibitors of picornavirus replication

Abstract: Picornaviruses cover a large family of pathogens that have a major impact on human but also on veterinary health. Although most infections in man subside mildly or asymptomatically, picornaviruses can also be responsible for severe, potentially life-threatening disease. To date, no therapy has been approved for the treatment of picornavirus infections. However, efforts to develop an antiviral that is effective in treating picornavirus-associated diseases are ongoing. In 2007, Schering-Plough, under license of … Show more

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Cited by 232 publications
(223 citation statements)
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References 367 publications
(349 reference statements)
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“…However, until now there is only experimental data confirming the NTPase but not the helicase activity of this nonstructural protein of norovirus (Hardy, 2005). , 2008a;De Palma et al, 2008c;Norder et al, 2011) could as well be inhibitors of the NTPase of norovirus. The multiple mechanisms through which compounds could inhibit the helicase/NTPase have been extensively described elsewhere .…”
Section: Ntpasementioning
confidence: 96%
See 1 more Smart Citation
“…However, until now there is only experimental data confirming the NTPase but not the helicase activity of this nonstructural protein of norovirus (Hardy, 2005). , 2008a;De Palma et al, 2008c;Norder et al, 2011) could as well be inhibitors of the NTPase of norovirus. The multiple mechanisms through which compounds could inhibit the helicase/NTPase have been extensively described elsewhere .…”
Section: Ntpasementioning
confidence: 96%
“…The inhibitors of the 3C protease of picornavirus, such as ruprintrivir, may potentially inhibit the norovirus protease given the overall similarity between the proteases of these viruses. (Binford et al, 2005;De Palma et al, 2008c;Leyssen et al, 2008).…”
Section: Proteasementioning
confidence: 99%
“…As of today no therapeutics have been approved for the treatment of these infections (De Palma et al, 2008;Schmidtke, 2011)(De Palma et al, 2008;Rollinger and Schmidtke, 2011). Several capsid-binding inhibitorsmolecules (CIs) are being investigated as promising drug candidates (Andries et al, 1991;Diana, 2003;Makarov et al, 2005;Watson et al, 2003) (Andries et al, 1991;Diana, 2003;Makarov et al, 2005;Watson et al, 2003), the most developed ones being pleconaril and vapendavir (Diana et al, 1995;Feil et al, 2012) (Diana et al, 1995;Feil et al, 2012).…”
Section: Introductionmentioning
confidence: 99%
“…They cause a wide range of acute and chronic diseases such as respiratory infections, meningitis, pancreatitis, encephalitis, and myocarditis (Pallansch and Roos, 2007;Turner and Couch, 2007). As of today no therapeutics have been approved for the treatment of these infections (De Palma et al, 2008;Rollinger and Schmidtke, 2011). Several capsid-binding molecules (CIs) are being investigated as promising drug candidates (Andries et al, 1991;Diana, 2003;Makarov et al, 2005;Watson et al, 2003), the most developed ones being pleconaril and vapendavir (Diana et al, 1995;Feil et al, 2012).…”
Section: Introductionmentioning
confidence: 99%
“…Um grande número de agentes experimentais foi testado para suas atividades anti-picornavírus, com resultados pouco animadores, porém alguns têm sido submetidos à fase inicial de testes clínicos (SMITH et al, 1986;DE PALMA et al, 2008).…”
Section: -Diagnóstico Tratamento E Prevençãounclassified