Selective inner retinal layer involvement in early syphilitic retinitis as evidenced by spectral domain OCT

Klemencic, Stephanie A.; Newman, Tricia L.; Messner, Leonard V.

doi:10.1016/s1888-4296(11)70039-5

Cited by 2 publications

(2 citation statements)

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“…In our case series, one patient had anterior uveitis and three had panuveitis, with two cases also presenting with optic neuropathy. Acute syphilitic posterior placoid chorioretinitis, as seen in Case 2, is a specific but rare manifestation of ocular syphilis [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…While the pathogenesis of syphilitic uveitis is unclear, some hypotheses suggest direct invasion and secondary obstruction of the choriocapillaris by spirochetes, and deposition of soluble immune complexes in the tissues [ 11 ]. In acute syphilitic posterior placoid chorioretinitis, irregular hyper-reflectivity of the RPE with nodular elevations corresponds to hyperfluorescent dots within the yellow-white discoid lesions on FAF, indicating lipofuscin accumulation and incomplete phagocytosis of retinal photoreceptor cell outer segment [ 1 , 13 ].…”

Section: Discussionmentioning

confidence: 99%

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Syphilitic Uveitis With Diverse Clinical Presentations: Multimodal Imaging as a Useful Adjunctive Tool for Diagnosis and Treatment

Kawamoto,

Hiyama,

Sada

et al. 2024

Cureus

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We report four cases of syphilitic uveitis with diverse clinical presentations. All patients were men who have sex with women, and were aged 19-68 years, and none were HIV-positive. All cases were bilateral. One case presented with anterior uveitis, while three exhibited panuveitis. One patient had acute syphilitic posterior placoid chorioretinitis and two had retinal vasculitis resulting in damage to the outer retinal and retinal pigment epithelium. The rapid plasma reagin (RPR) test and Treponema pallidum (TP) hemagglutination test were both positive in all cases. Six of eight eyes had improved vision and best-corrected visual acuity better than 20/20 after antibiotic treatment. Serological testing is mandatory for the diagnosis of syphilitic uveitis. Additionally, multimodal imaging, including optical coherence tomography (OCT), fundus autofluorescence (FAF), and fluorescein angiography (FA), can provide useful adjunctive information for early diagnosis and assessment of treatment response.

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Section: Discussionmentioning

confidence: 99%