Selective laser sintering of β-TCP/nano-58S composite scaffolds with improved mechanical properties

Liu, Jinglin; Gao, Chengde; Feng, Pei; Peng, Shuping; Shuai, Cijun

doi:10.1016/j.matdes.2015.06.161

Cited by 18 publications

(7 citation statements)

References 35 publications

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“…Research has demonstrated that the addition of ≤ 5 wt% of BG® [453,454], as well as other bioactive glass [455], can improve the biological properties of HA. Equally, increases in mechanical properties were also reported when BG was added, and for other bioresorbable ceramics as well [220,290,456]. At typical HA sintering temperatures, the glasses melt, and through capillary forces and particle rearrangement, enhances the densification of HA [455][456][457][458].…”

Section: Introductionmentioning

confidence: 85%

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Porous hydroxyapatite scaffolds fabricated from nano-sized powder via honeycomb extrusion

Elbadawi¹

2017

Adv. Mater. Lett.

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Section: Introductionmentioning

confidence: 85%

“…This allows for complex geometries to be obtained, with a relatively high spatial resolution. SFF approaches include the use of a laser to sinter CaP powders layer-by-layer [220], or an inkjet print-head that deposits inks that bind adjacent CaP powders to form green bodies [221].…”

Section: Solid Freeform Fabricationmentioning

confidence: 99%

Porous hydroxyapatite scaffolds fabricated from nano-sized powder via honeycomb extrusion

Elbadawi¹

2017

Adv. Mater. Lett.

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“…296 More recently, nano-sized 58S bioactive glass (composition: 58 mol % SiO 2 , 33 mol % CaO, 9 mol % P 2 O 5 ) synthesized by sol-gel method has been added to b-TCP in order to obtain composite scaffold prepared via selective laser sintering. 297 It was observed that, for low glass amounts, the nano-58S dispersed phase was able to improve the mechanical performance of the samples. On the other hand, an excessive glass addition decreased the mechanical strength of the scaffolds.…”

Section: B-tcp/bioglass Composites: a Brief Overviewmentioning

confidence: 98%

“…Composite scaffolds based on β‐TCP and bioactive glasses have been also proposed by Cai et al In this case, a calcium phosphate glass belonging to the Na 2 O‐MgO‐CaO‐P 2 O 5 family was employed . More recently, nano‐sized 58S bioactive glass (composition: 58 mol % SiO 2 , 33 mol % CaO, 9 mol % P 2 O 5 ) synthesized by sol–gel method has been added to β‐TCP in order to obtain composite scaffold prepared via selective laser sintering . It was observed that, for low glass amounts, the nano‐58S dispersed phase was able to improve the mechanical performance of the samples.…”

Section: β‐Tcp/bioglass Composites: a Brief Overviewmentioning

confidence: 99%

Hydroxyapatite and tricalcium phosphate composites with bioactive glass as second phase: State of the art and current applications

Bellucci

Sola

Cannillo

2015

J Biomedical Materials Res

121

102

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Calcium phosphates are among the most common biomaterials employed in orthopaedic and dental surgery. The efficacy of such systems as bone substitutes and bioactive coatings on metallic prostheses has been proved by several clinical studies. Among these materials, hydroxyapatite (HA) and tricalcium phosphate (TCP) play a prominent role in medical practice since the '80s. In the last years, numerous attempts to combine HA or TCP with bioactive glasses have been made. There are two main motivations for sintering calcium phosphates with a glassy phase: on the one hand, it is possible to tune the dissolution of the final system and to enhance its biological response through the synergistic combination of two bioactive phases; on the other hand, the glass acts as a sintering aid with the aim to increase the densification of the composite and thus its mechanical strength. In this sense, TCP and HA are penalized by their relatively poor fracture toughness and tensile strength compared to natural bone, which makes it impossible to use them in load-bearing applications. Moreover, the bioactivity index of pure calcium phosphates is typically lower with respect to that of many bioactive glasses. In this review, the state of the art and current applications of composites, based on HA or TCP with bioactive glass as second phase, are presented and discussed. A special emphasis is given to the processing and mechanical behaviour of these systems, together with their biological implications, as a function of the composition of the glass employed as second phase.

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“…This approach also enhances the bioactivity of composite materials through the combination of two bioactive phases. [13][14][15] Bioactive glasses, specially 45S5 bioglass, are well known to be biocompatible, highly bioactive, and both osteoconductive and osteoinductive. These bioceramics are able to bond strongly to hard and soft tissues through the development of a surface layer of hydroxycarbonate apatite, and their ionic dissolution products (e.g.…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of highly porous ceramic-based nanocomposite scaffolds with improved mechanical properties using the liquid phase-assisted sintering method

Kazemi

Nazari

et al. 2018

Proceedings of the Institution of Mechanical Engineers, Part L:

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Recent advances in the field of biomaterials have led to the development of ceramic–matrix nanocomposites with enhanced mechanical properties, which is essential for hard tissue scaffolds. In this study, the improvement in mechanical and biological properties of β-tricalcium phosphate reinforced with 45S5 bioactive glass under different sintering conditions was studied. In order to improve the thermal stability and biological responses, β-tricalcium phosphate was doped with 5 mol% strontium ions. Highly porous nanocomposites, with different weight ratios of Sr-tricalcium phosphate/bioactive glass (75/25, 50/50, 25/75), were fabricated through the foam replication method by sintering samples under various thermal conditions (1200–1250 ℃/0–1 h). The effects of bioactive glass content and sintering parameters on microstructure and mechanical behaviors of the nanocomposites were assessed. The obtained results showed that increasing 45S5 bioactive glass content, sintering temperature, and dwelling time gradually improved the mechanical properties of final products which were ascribed to the improved ceramic densification. The composites with the optimal compressive strength were selected to apply in further characterization and cell culture experiments. The selected scaffolds showed excellent bioactivity since a continuous layer of minerals covered the entire surface of composites after immersion in simulated body fluid solution for two weeks. Moreover, the cell culture studies demonstrated that the composite scaffolds could well support the attachment and proliferation of MG-63 osteoblast-like cells. This investigation clearly concluded that the appropriate incorporation of 45S5 bioactive glass into the β-tricalcium phosphate matrix can effectively promote the mechanical behavior, bioactivity, and biocompatibility of the resultant composite scaffolds.

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Selective laser sintering of β-TCP/nano-58S composite scaffolds with improved mechanical properties

Cited by 18 publications

References 35 publications

Porous hydroxyapatite scaffolds fabricated from nano-sized powder via honeycomb extrusion

Porous hydroxyapatite scaffolds fabricated from nano-sized powder via honeycomb extrusion

Hydroxyapatite and tricalcium phosphate composites with bioactive glass as second phase: State of the art and current applications

Preparation and characterization of highly porous ceramic-based nanocomposite scaffolds with improved mechanical properties using the liquid phase-assisted sintering method

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