Selective laser trabeculoplasty: A review

Landers, John

doi:10.1111/ceo.13979

Cited by 9 publications

(2 citation statements)

References 83 publications

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“…The only factor reliably shown to be associated with SLT efficacy is pre‐SLT IOP. A higher IOP before SLT seems to be associated with a greater SLT response (Landers, 2021).…”

Section: Introductionmentioning

confidence: 99%

The impact of topical NSAID treatment on selective laser trabeculoplasty efficacy

Dahlgren

Ayala

Zetterberg

2022

Acta Ophthalmologica

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Purpose: Selective laser trabeculoplasty (SLT) is a first-line intervention for glaucoma, with the aim to reduce the intraocular pressure (IOP). Topical non-steroidal anti-inflammatory drugs (NSAIDs) are sometimes prescribed after SLT. However, it has been proposed that such treatment may either increase or reduce SLT efficacy. The purpose of this study was to investigate this further. Methods:The study was a retrospective chart review, including 192 eyes of 192 patients, half of which received a course of NSAID eyedrops after SLT. Absolute and relative IOP reduction 3-12 weeks after SLT was compared. Furthermore, subgroup analyses, a multiple linear regression analysis, and a Kaplan-Meier survival analysis regarding time to treatment escalation were performed. Results:The mean absolute IOP reduction was 4.3 ± 3.4 mmHg in the NSAID group and 5.4 ± 4.1 mmHg in the control group (p = 0.049). Relative IOP reduction was 17.5% ± 13.0% and 21.8% ± 14.8% in the NSAID and control groups, respectively (p = 0.033). The same tendency of superior results in control eyes compared with NSAID eyes was seen in an extensive subgroup analysis. A multiple linear regression analysis confirmed NSAID treatment as a negative predictor of IOP reduction after adjustment for covariates (p = 0.023). Survival analysis showed a longer median time to treatment escalation in the control group, though not statistically significant. Conclusion:Topical NSAID treatment was not associated with an increased SLT efficacy. On the contrary, the present study is the first to demonstrate that SLT effectiveness may even be reduced by NSAIDs.

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“…The only factor reliably shown to be associated with SLT efficacy is pre‐SLT IOP. A higher IOP before SLT seems to be associated with a greater SLT response (Landers, 2021).…”

Section: Introductionmentioning

confidence: 99%

The impact of topical NSAID treatment on selective laser trabeculoplasty efficacy

Dahlgren

Ayala

Zetterberg

2022

Acta Ophthalmologica

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“…Since 2000, the management of glaucoma has continued to expand beyond intraocular pressure lowering eye drops and filtering surgery to include selective laser trabeculoplasty and microinvasive glaucoma surgery, or SLT and MIGS, respectively. Landers 16 provided a comprehensive review of SLT, covering mechanism of action, technical aspects of the procedure, application in different subtypes of glaucoma, outcomes and complications, repeatability and cost effectiveness. Berdahl et al 17 reported the 4-year outcomes of a trabecular microbypass stent (iStent inject) implantation, combined with travoprost eye drops, in a prospective, non-randomised study involving 53 individuals with open-angle glaucoma.…”

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confidence: 99%

A focus on glaucoma

Smith

2022

Clinical Exper Ophthalmology

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Glaucoma is the focus of the 2022 Clinical and Experimental Ophthalmology Special Issue. This condition has a worldwide prevalence of approximately 3.5%, 1 and it is the most common cause of irreversible blindness globally. 2 Across eight articles, our Special Issue covers a range of glaucoma-related topics, including epidemiology and public health, 3 genetics and personalised risk assessment, 4 pathogenesis, 5 ophthalmic imaging for diagnosis and monitoring, 6 medical therapy 7 and surgical management, 8 plus childhood glaucoma 9 and normaltension glaucoma. 10 I anticipate that this collection of articles, authored by experts in the field from Australia, Brazil, Hong Kong SAR and the United States, will wet the reader's appetite for additional content on glaucoma; over the past 2 years, Clinical and Experimental Ophthalmology has published close to 30 articles on various aspects of this important condition.Several papers have showed the value of optical coherence tomography (OCT) in identifying and following glaucoma. Chen et al. 11 employed anterior segment swept source-OCT to measure various iris dimensions in 40 individuals with primary open-angle glaucoma and 114 healthy persons. A comparison of the parameters between the groups demonstrated that iris area (with cutoff set at 1.43 mm 2 ) had an 85% sensitivity and a 65% specificity for identifying those people with glaucoma. In the report of a cross-sectional study of 100 eyes with open angles, suspected of glaucoma or having recently developed glaucoma, plus a longitudinal study of 61 eyes, the PROGRESSA Study Group 12 compared common spectral domain-OCT machines. They showed that different devices were equally effective in tracking progression of nerve fibre layer and ganglion cell layer/inner plexiform layer changes, and found that nerve fibre layer loss advanced relatively rapidly.The main focus of glaucoma management is reduction of intraocular pressure, and numerous life-style factors have been shown to impact the pressure level. Vera et al. 13 followed up on previous observations related to two common and unrelated factors: consumption of caffeine and low-intensity exercise, known to, respectively, increase and decrease the intraocular pressure. In a placebo-controlled, double-blind, balanced cross-over

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Safety and efficacy of laser trabeculoplasty compared to drug therapy for the management of open-angle glaucoma: systematic review and meta-analysis study

Zhang,

Yang,

et al. 2024

Graefes Arch Clin Exp Ophthalmol

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Selective laser trabeculoplasty: A review

Cited by 9 publications

References 83 publications

The impact of topical NSAID treatment on selective laser trabeculoplasty efficacy

The impact of topical NSAID treatment on selective laser trabeculoplasty efficacy

A focus on glaucoma

Safety and efficacy of laser trabeculoplasty compared to drug therapy for the management of open-angle glaucoma: systematic review and meta-analysis study

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