Selective layer-free blood serum ionogram based on ion-specific interactions with a nanotransistor

Sivakumarasamy, Ragavendran; Hartkamp, Remco; Siboulet, Bertrand; Dufrêche, J.-F.; Nishiguchi, Katsuhiko; Fujiwara, Akira; Nicolas, Clément

doi:10.1038/s41563-017-0016-y

Cited by 42 publications

(51 citation statements)

References 52 publications

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“…[134] This characteristic offered an opportunity to study the interaction of other ions neglecting the effect of pH changes or pH-mediated reactions. [134] This characteristic offered an opportunity to study the interaction of other ions neglecting the effect of pH changes or pH-mediated reactions.…”

Section: Sensing the Ions Using Silicon Nanowires Fet (Isfet)mentioning

confidence: 99%

Hybrid Silicon Nanowire Devices and Their Functional Diversity

et al. 2019

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In the pool of nanostructured materials, silicon nanostructures are known as conventionally used building blocks of commercially available electronic devices. Their application areas span from miniaturized elements of devices and circuits to ultrasensitive biosensors for diagnostics. In this Review, the current trends in the developments of silicon nanowire‐based devices are summarized, and their functionalities, novel architectures, and applications are discussed from the point of view of analog electronics, arisen from the ability of (bio)chemical gating of the carrier channel. Hybrid nanowire‐based devices are introduced and described as systems decorated by, e.g., organic complexes (biomolecules, polymers, and organic films), aimed to substantially extend their functionality, compared to traditional systems. Their functional diversity is explored considering their architecture as well as areas of their applications, outlining several groups of devices that benefit from the coatings. The first group is the biosensors that are able to represent label‐free assays thanks to the attached biological receptors. The second group is represented by devices for optoelectronics that acquire higher optical sensitivity or efficiency due to the specific photosensitive decoration of the nanowires. Finally, the so‐called new bioinspired neuromorphic devices are shown, which are aimed to mimic the functions of the biological cells, e.g., neurons and synapses.

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Section: Sensing the Ions Using Silicon Nanowires Fet (Isfet)mentioning

confidence: 99%

Hybrid Silicon Nanowire Devices and Their Functional Diversity

et al. 2019

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“…(39), equipped with the density profile approximation in Eq. (14). After some algebraic manipulations, we obtain the following expression for the Darcy-Weisbach friction factor in nanochannels:…”

Section: Darcy-weisbach Friction Factor In Nanopipesmentioning

confidence: 99%

“…Fluid interfaces are ubiquitous in a wide spectrum of natural phenomena and technological applications, from the wetting properties of plant leaves 1 and insects walking and jumping on water 2 to recent technological advances in micro-/nanofluidics, 3,4 design of surfaces with controllable wetting properties, 5-8 colloidal science, 9,10 bioengineering, [11][12][13] sensing, 14 and biomimetics. 15,16 All these demand a molecular-level understanding of the fundamental physical properties of matter on interfaces.…”

Section: Introductionmentioning

confidence: 99%

Macroscopic relations for microscopic properties at the interface between solid substrates and dense fluids

Russo

Durán-Olivencia

Kalliadasis

et al. 2019

The Journal of Chemical Physics

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“…In addition, it has been shown to be sensitive to surface potential variations associated with the interaction occurring at the sensing interface, and it is hence a suitable platform to investigate ion-surface interactions. [20,21] pH value is an important parameter in numerous fields. Almost every biological process is pH-dependent, especially in the range from 8 to 3, where the pH variations reflect a myriad of critical information such as human health, [22,23] viral behavior, [24,25] bacterial activity, [26] and so on.…”

Section: Knowledge Of Interfacial Interactions Between Analytes and Fmentioning

confidence: 99%

Synergy of Ionic and Dipolar Effects by Molecular Design for pH Sensing beyond the Nernstian Limit

et al. 2019

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interface generates original signal and plays a crucial role in the sensing process. In ion sensors, the interaction between ions and ion receptors can lead to accumulation of interfacial charges, thereby causing an interfacial potential change that can be electronically readout. [3] A versatile sensing platform can also be designed by functionalizing the sensor surface with self-assembled organic monolayers (SAMs), which offers the possibility to tailor the chemical and/or physical interactions of the sensor surface with analytes. These interfacial interactions can generate additional changes in surface dipoles and/or charges on the sensing surface, [4,5] which can in turn affect the electrical properties of the surface and tune the sensitivity. [6][7][8] It can be emphasized that both surface charge and dipole play an equally important role in establishing the surface equilibrium state. The dipole effect can be engineered in a controllable and systematic way. Therefore, modulating the molecular dipole moment to enhance device performance holds promises in numerous applications. [9][10][11] However, the molecular dipole effect is strongly dependent on multiple parameters in practice, such as dipole orientation, distribution, and packing density of each molecule within the SAM. [12,13] These parameters are strongly inter-correlated. For example, increasing the dipole moment of the surface immobilized molecules can enhance the electrostatic repulsions between neighboring dipoles, influence the packing density, and even change the configuration of the SAM. Thus, in order to engineer the interfacial dipole in a controllable manner, a rational design of the system is needed.Since the dipole moment originates from the charge separation between atoms due to their difference in electronegativity, changing the electronegativity on the molecular substituent can be an efficient way to modulate the molecular dipole. A dipole moment can also be formed by ion pair of cation and anion, [14,15] which can be embodied by a well-known phenomenon that the electrostatic attraction between cations and anions can lead to a significant change in surface wettability. [16,17] This ionic dipole is strongly dependent on the polarizability of the ionic pair, and is affected by the properties of the ions such as ionic radius and hydration energy. [18,19] Therefore, artificial designs to form ion pairs can be an alternative to create dipoles on the sensing surface for modulation of its sensitivity. With proper molecular Knowledge of interfacial interactions between analytes and functionalized sensor surfaces, from where the signal originates, is key to the development and application of electronic sensors. The present work explores the tunability of pH sensitivity by the synergy of surface charge and molecular dipole moment induced by interfacial proton interactions. This synergy is demonstrated on a silicon-nanoribbon field-effect transistor (SiNR-FET) by functionalizing the sensor surface with properly designed chromophore molecules. The ch...

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Selective layer-free blood serum ionogram based on ion-specific interactions with a nanotransistor

Cited by 42 publications

References 52 publications

Hybrid Silicon Nanowire Devices and Their Functional Diversity

Hybrid Silicon Nanowire Devices and Their Functional Diversity

Macroscopic relations for microscopic properties at the interface between solid substrates and dense fluids

Synergy of Ionic and Dipolar Effects by Molecular Design for pH Sensing beyond the Nernstian Limit

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