Selective Loss of the Photopic Negative Response in Patients With OpticNerve Atrophy

Gotoh, Yasutaka; Machida, Shigeki; Tazawa, Yutaka

doi:10.1001/archopht.122.3.341

Cited by 105 publications

(83 citation statements)

References 18 publications

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“…12,15 PhNR is also selectively reduced in eyes with optic nerve atrophy, which is induced by trauma, compression, inflammation, ischemia, or gene mutation. [8][9][10] Our results provide additional evidence that focal macular PhNR is immediately and strongly attenuated by the onset of optic neuritis and that PhNR did not improve even after patients were treated with systemic corticosteroids, which resulted to improved visual acuity and visual field but not optic atrophy.…”

Section: Discussionmentioning

confidence: 61%

“…A previous report has shown that PhNR amplitude remained unchanged in the early stages of optic neuropathy and that PhNR was reduced or completely lost as RNFL thinning progressed. 9 However, they recorded PhNR in patients with optic nerve atrophy by using full-field ERG, which is the summed response from the entire retina. Therefore, full-field ERG is not an ideal tool to assess the function of localized retinal areas.…”

Section: Reduction Of Focal Macular Erg In Patients With Optic Neuritismentioning

confidence: 99%

“…1,2 A number of studies suggest that the PhNR in the photopic ERG originates primarily from activity of RGCs and their axons. [1][2][3][4][5][6][7][8][9] In clinical studies using full-field ERGs, the PhNR amplitude was reduced in various diseases that involves RGC damageFfor example, glaucoma, [3][4][5] retinal vascular disease, 6,7 and optic nerve diseases. [8][9][10] Several researchers measured PhNR by using focal macular ERG in humans and monkeys.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4][5][6][7][8][9] In clinical studies using full-field ERGs, the PhNR amplitude was reduced in various diseases that involves RGC damageFfor example, glaucoma, [3][4][5] retinal vascular disease, 6,7 and optic nerve diseases. [8][9][10] Several researchers measured PhNR by using focal macular ERG in humans and monkeys. [11][12][13][14][15] Focal macular PhNR detected early glaucoma with higher sensitivity and specificity than full-field PhNR.…”

Section: Introductionmentioning

confidence: 99%

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Focal macular photopic negative response in patients with optic neuritis

Nakamura

Miyamoto

Yokota

et al. 2011

Eye

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Purpose To investigate, by focal macular electroretinography (ERG), the change of photopic negative response (PhNR) in the recovery of visual function in patients with optic neuritis. Methods Focal macular ERG was recorded from nine patients with acute optic neuritis (38.6±10.2 years). The photostimulator device projected 151 visual angle spotlight onto the macula. Focal macular ERG recording was performed at the onset and at 1 month and 6 months after the onset of optic neuritis. The results were compared between each recording for seven of the patients. Results All patients decreased in the vision below 20/100 and had central scotoma. Vision improved more than 20/20 within 1 month and full-visual field recovered within 6 months after the onset in all patients. The amplitude of the a-wave, b-wave, and PhNR of focal macular ERG at the onset was significantly attenuated in eyes with optic neuritis (66.8±15.5, 65.8±17.7, and 65.2±14.4% of normal control, respectively). The amplitude of the a-wave and b-wave increased gradually after steroid pulse therapy. The increase in a-wave amplitude was significant at 6 months (P ¼ 0.046), whereas the PhNR amplitude did not show any significant change over 6 months after the onset of optic neuritis. Conclusions Our results suggest that inflammation at the onset of optic neuritis leads to functional deficits that extend to at least the inner nuclear layers of the retina, and that all but the ganglion cell layers of retina recover.

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Section: Discussionmentioning

confidence: 61%

Section: Reduction Of Focal Macular Erg In Patients With Optic Neuritismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Focal macular photopic negative response in patients with optic neuritis

Nakamura

Miyamoto

Yokota

et al. 2011

Eye

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“…19 In addition, it has been reported that the PhNR is selectively attenuated in eyes with optic nerve atrophy induced by trauma, compression, infl ammation, gene mutation, and ischemia. 20,21,22 Colotto A et al reported signifi cant reduction in amplitude of PhNR (average 62%) in primary open angle glaucoma (POAG) as compared to normals. 23 Similarly, Vishwanathan S et al 20 , in a study of 62 normals, 18 POAG patients and 7 POAG suspects demonstrated that the amplitude of PhNR was greatly reduced in the POAG group as well as the suspect group in comparison to normals.…”

Section: Photopic Negative Response In Glaucomamentioning

confidence: 99%

Electrophysiology in Glaucoma - A Review

Goyal¹,

Seetharam²,

Arora³

et al. 2013

Delhi Journal of Ophthalmology

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Functional alterations of retinal neurons and vascular involvement progress simultaneously in the Psammomys obesus model of diabetic retinopathy

Dellaa¹,

Mbarek²,

Kahloun

et al. 2021

J Comp Neurol

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To investigate the progression of diabetic retinopathy (DR) in a new diurnal animal model, we monitored clinically the DR in Psammomys obesus (P. obesus) during 7 months using electroretinography (ERG) and imaging techniques. After the onset of DR, all ERG components decreased progressively. In scotopic conditions, by 3‐months of disease progression, the diabetic P. obesus displayed a significant decrease in amplitude of b‐max, b‐wave responses, and mixed b‐waves. While mixed a‐wave decreased between 4 and 7 months. Significant differences of OP2 appeared following 1 month of disease. In photopic conditions, we noticed a decrease in the a‐wave at 2 months, while it took more than 5 months in b‐wave amplitude. The photopic negative response (PhNR) and the i‐wave amplitudes decreased following 4 and 5 months. OP1 and OP2 were the first to be altered and a significant decrease in the amplitude started after 3 months. Finally, 30 Hz‐flicker and photopic S‐cone were impaired after 2 and 3 months, respectively. The assessment of the eye fundus of the retina revealed an abnormal vascular architecture appeared at Months 6 and 7. In addition, we noticed exudates in the superior periphery of the retina at the same stage. The retina thickness showed a significant reduction at Month 7. Our results indicate that the clinical correlates of human DR are present in diabetic P. obesus. The depressed of ERGs, disruption of retinal architecture, and the appearance of exudates may reflect vascular and neuronal damage throughout the retina as are seen in the advanced stages of human DR.

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Selective Loss of the Photopic Negative Response in Patients With OpticNerve Atrophy

Cited by 105 publications

References 18 publications

Focal macular photopic negative response in patients with optic neuritis

Focal macular photopic negative response in patients with optic neuritis

Electrophysiology in Glaucoma - A Review

Functional alterations of retinal neurons and vascular involvement progress simultaneously in the Psammomys obesus model of diabetic retinopathy

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