Selective method for the determination of cefdinir in human plasma using liquid chromatography electrospray ionization tandam mass spectrometry

Simultaneous determination of cefdinir and cefixime in human plasma by RP-HPLC/UV detection method: Method development, optimization, validation, and its application to a pharmacokinetic study

“…1, showing that a simple extraction proce- dure consisting of deproteination and extraction with 3 parts of 6% TCA solution (aqueous) followed by volume make up with the aqueous component of the mobile phase obtained maximum recoveries of both cefixime and cefdinir from human plasma samples. These results were consistent with the previous results [10,16]. The solid-phase extraction procedure has also been reported for the extraction of the cefdinir from plasma samples [11].…”

“…To our knowledge, only three papers [10][11][12] have been reported so far on the liquid-chromatographic determination of cefdinir in biological samples. However, one of these methods [10] have utilized very expensive mass spectrometric detector, one involves tedious and expensive solid-phase extraction technique and it is not validated according to international guidelines [11], and the third one, which is not very much sensitive, hardly involves any sample pre-treatment technique [12].…”

“…However, one of these methods [10] have utilized very expensive mass spectrometric detector, one involves tedious and expensive solid-phase extraction technique and it is not validated according to international guidelines [11], and the third one, which is not very much sensitive, hardly involves any sample pre-treatment technique [12]. Thus it is not suitable for selective extraction of cefdinir from plasma samples.…”

Rapid quantification of lisinopril in human plasma by liquid chromatography/tandem mass spectrometry

“…Owing to the inherent high selectivity and sensitivity of the LC-MS/MS technique, protein precipitation (PPT) has become one of the most widely used biological sample pretreatment methods for its simple and timesaving procedure (Chen et al, 2006;Ramakrishna et al, 2006;Medvedovici et al, 2005). To obtain a clean chromatogram and achieve a sufficient extraction recovery, three types of precipitation reagents (methanol, acetonitrile and perchloric acid) were investigated during the experiment.…”

Development and Validation of New Rp-Uplc Method for the Determination of Cefdinir in Bulk and Dosage Form

“…As a result, many organisms resistant to penicillin's and some cephalosporin are susceptible to Cefdinir [9]. Entire survey of the literature of cefdinir exposed several methods for determination in pharmaceutical formulations and biological matrices like spectro-photometry [10], polarographic technique [11], HPLC [12] and LC/MS/MS methods [13]. However, maximum of these analytical methods do not appear to have general utility especially at the industrial level where simple, cost-effective and specific methods are needed [14].…”