Selective microstructural integrity impairments of the anterior corpus callosum are associated with cognitive deficits in obstructive sleep apnea

Zhang, Biao; Zhu, Daomin; Zhao, Wenming; Yang, Ying; Zhang, Cun; Zhu, Jiajia; Yu, Yongqiang

doi:10.1002/brb3.1482

Cited by 21 publications

(33 citation statements)

References 56 publications

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“…Furthermore, a recent study performed by Baril et al (2020) (N = 65) found that mild OSA was associated with widespread areas of lower diffusivity along the skeleton in the centre of white matter (WM) in projection, association, and commissural fibres but not the brainstem, as well as lower free-water fraction and no changes in fractional anisotropy (FA) or WM hyperintensity volume, while subjects with moderate to severe OSA showed lower axonal diffusivity in the corpus callosum (CC) [13]. A similar result has also been reported by Zhang et al (2019) (N = 44), where subjects with moderate-severe OSA exhibited significant lower FA and higher mean and radial diffusivity in the anterior CC [25]. Furthermore, Koo et al (2020) (N = 79, male only) found OSA to be associated with lower FA in the bilateral anterior thalamic radiations and the right uncinated fasciculus [26].…”

Section: Introductionsupporting

confidence: 69%

“…In this review, we have summarised recent findings on the association between OSA and brain structure, cognition, and the two most common neurodegenerative disorders, namely Alzheimer's dementia and Parkinson's disease. Overall, recent studies reported associations between OSA and grey and white matter alterations [3, 10-12, 20, 22-24], and changes in brain diffusion [13,25,26], as well as impaired cognition, specifically regarding memory [5,6,26,32], attention [5,7,8,30,31], and executive control [7,8]. Furthermore, subjects with OSA were found to have a higher risk of developing mild cognitive impairment (MCI) [5,27], Alzheimer's dementia [16,17,[39][40][41], and Parkinson's disease [47], and show shorter progression times between cognitively normal and MCI or MCI and Alzheimer's dementia [17].…”

Section: Discussionmentioning

confidence: 98%

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The Link Between Obstructive Sleep Apnoea and Neurodegeneration and Cognition

Weihs

Frenzel

Grabe

2021

Curr Sleep Medicine Rep

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Purpose of Review Obstructive sleep apnoea (OSA) is increasingly found to have an impact on neurodegeneration. In this review, we summarise recent findings on the association between OSA and brain morphology, cognition, and processes related to Alzheimer’s dementia (AD) and Parkinson’s disease (PD). Recent Findings Associations between OSA and alterations in grey and white matter, brain diffusivity, and deficits in memory, attention, and executive control were reported. Furthermore, OSA was correlated with higher risks of developing AD and PD and associated pathophysiology. Treatment was found to alleviate but not reverse some of the damage. Summary There are strong indications that OSA plays a major role in neurodegenerative processes. The broad picture however remains elusive, likely due to insufficient sample sizes, heterogeneous outcomes, and OSA definitions failing to quantify the disorder’s sub-processes. While studies resolving these issues are required, the available evidence shows OSA to be a promising target to slow neurodegeneration and delay the onset of related disorders.

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Section: Introductionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 98%

The Link Between Obstructive Sleep Apnoea and Neurodegeneration and Cognition

Weihs

Frenzel

Grabe

2021

Curr Sleep Medicine Rep

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“…A more heterogeneous portrait was found in middle‐aged adults with OSA (results are summarized in Table ) (Castronovo et al, ; Chen et al, ; Koo et al, ; Kumar et al, ; Kumar et al, ; Lee et al, ; Macey et al, ; Macey et al, ; Zhang et al, ). In fact, while decreased FA suggesting poor white matter integrity was repeatedly found in middle‐aged individuals with OSA, as would be predicted by ongoing neurodegenerative processes (Sexton et al, ), lower diffusivities (MD, RD, and AD) were reported more consistently than higher diffusivities.…”

Section: Introductionmentioning

confidence: 98%

Cerebral white matter diffusion properties and free‐water with obstructive sleep apnea severity in older adults

Baril

Gagnon

Descoteaux

et al. 2020

Human Brain Mapping

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Characterizing the effects of obstructive sleep apnea (OSA) on the aging brain could be key in our understanding of neurodegeneration in this population. Our objective was to assess white matter properties in newly diagnosed and untreated adults with mild to severe OSA. Sixty‐five adults aged 55 to 85 were recruited and divided into three groups: control (apnea‐hypopnea index ≤5/hr; n = 18; 65.2 ± 7.2 years old), mild (>5 to ≤15 hr; n = 27; 64.2 ± 5.3 years old) and moderate to severe OSA (>15/hr; n = 20; 65.2 ± 5.5 years old). Diffusion tensor imaging metrics (fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity, and mean diffusivity) were compared between groups with Tract‐Based Spatial Statistics within the white matter skeleton created by the technique. Groups were also compared for white matter hyperintensities volume and the free‐water (FW) fraction. Compared with controls, mild OSA participants showed widespread areas of lower diffusivity (p < .05 corrected) and lower FW fraction (p < .05). Participants with moderate to severe OSA showed lower AD in the corpus callosum compared with controls (p < .05 corrected). No between‐group differences were observed for FA or white matter hyperintensities. Lower white matter diffusivity metrics is especially marked in mild OSA, suggesting that even the milder form may lead to detrimental outcomes. In moderate to severe OSA, competing pathological responses might have led to partial normalization of diffusion metrics.

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“…Many neuro-imaging studies have been conducted to reveal the structural changes in the brain in OSA, the pathophysiology of which has not yet been fully elucidated [ 8 , 9 ]. One of the common aims of studies on neurological diseases is to examine anatomic and functional changes of the brain and to evaluate their relationship with the disruption in cognitive processes.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the corpus callosum shape in patients with obstructive sleep apnea

et al. 2021

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Background The aim of this study was to examine whether or not there was a difference in corpus callosum shape between patients with mild to moderate and severe obstructive sleep apnea (OSA) compared with patients who have simple snoring. Methods The landmark coordinate data was obtained from the mid-sagittal magnetic resonance imaging (MRI) images of 70 patients who underwent polysomnography. For comparisons, mild and moderate OSA groups were combined and analyses were performed on three groups; simple snoring/control group, mild or moderate OSA group, and severe OSA group. Results The corpus callosum shape of controls was significantly different from that of the severe OSA group. The most prominent deformities were observed in the genu and rostral body of the corpus callosum for the patients with severe OSA. No significant difference was found between mild/moderate OSA group and simple snoring group in terms of global corpus callosum shape. Conclusion The data demonstrated that severe OSA patients have structural changes in the corpus callosum and deformities may vary as the severity of disease changes.

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Selective microstructural integrity impairments of the anterior corpus callosum are associated with cognitive deficits in obstructive sleep apnea

Cited by 21 publications

References 56 publications

The Link Between Obstructive Sleep Apnoea and Neurodegeneration and Cognition

The Link Between Obstructive Sleep Apnoea and Neurodegeneration and Cognition

Cerebral white matter diffusion properties and free‐water with obstructive sleep apnea severity in older adults

Evaluation of the corpus callosum shape in patients with obstructive sleep apnea

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