Selective NMR detection of individual reaction components hyperpolarised by reversible exchange with para-hydrogen

Abstract

NMR spectroscopy can sometimes be hampered by two inherent weaknesses: low sensitivity and overlap of signals in complex mixtures. Hyperpolarisation techniques using para-hydrogen (including the method known as SABRE) can...

NMR methods for the analysis of mixtures

“…In a different approach, Norcott has combined SABRE hyperpolarisation with selective experiments to analyse the reaction mixtures produced by the methanolysis of an amide, at different stages of the reactions. 129 The spin order of parahydrogen can also be released by hydrogenation of the target substrate, using a metal catalyst. This concept, named para-hydrogen induced polarisation (PHIP), was first described by Bowers and Weitekamp in 1986, and reported experimentally a year later.…”

“…In a different approach, Norcott has combined SABRE hyperpolarisation with selective experiments to analyse the reaction mixtures produced by the methanolysis of an amide, at different stages of the reactions. 129 …”

HR-MAS DREAMTIME NMR for Slow Spinning ex Vivo and in Vivo Samples

“…Readers interested in the details of DREAMTIME NMR are encouraged to read the original treatise . However, to date, DREAMTIME NMR has only been applied to standard 5 mm solution-state NMR systems. − …”