Selective Oxidation of Sulfides Catalyzed by the Nanocluster Polyoxomolybdate (NH4)12[Mo36(NO)4O108(H2O)16]

Amini, Mojtaba; Naslhajian, Hadi; Farnia, S. Morteza F.; Hołyńska, Małgorzata

doi:10.1002/ejic.201500528

Cited by 12 publications

(5 citation statements)

References 33 publications

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“…In case of Trp-SiW 10 , the two enantiomeric forms of tryptophan were investigated. The giant-wheel-shaped (NH 4 ) 12 [Mo 36 (NO) 4 O 108 (H 2 O) 16 ], Mo 36 POM, was also prepared ( Amini et al, 2015 ) to evaluate the impact of the dimensions and shape.…”

Section: Resultsmentioning

confidence: 99%

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Mechanism of CK2 Inhibition by a Ruthenium-Based Polyoxometalate

Fabbian

Giachin

Bellanda

et al. 2022

Front. Mol. Biosci.

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CK2 is a Ser/Thr protein kinase involved in many cellular processes such as gene expression, cell cycle progression, cell growth and differentiation, embryogenesis, and apoptosis. Aberrantly high CK2 activity is widely documented in cancer, but the enzyme is also involved in several other pathologies, such as diabetes, inflammation, neurodegeneration, and viral infections, including COVID-19. Over the last years, a large number of small-molecules able to inhibit the CK2 activity have been reported, mostly acting with an ATP-competitive mechanism. Polyoxometalates (POMs), are metal-oxide polyanionic clusters of various structures and dimensions, with unique chemical and physical properties. POMs were identified as nanomolar CK2 inhibitors, but their mechanism of inhibition and CK2 binding site remained elusive. Here, we present the biochemical and biophysical characterizing of the interaction of CK2α with a ruthenium-based polyoxometalate, [Ru4(μ-OH)2(μ-O)4(H2O)4 (γ-SiW10O36)2]10− (Ru4POM), a potent inhibitor of CK2. Using analytical Size-Exclusion Chromatography (SEC), Isothermal Titration Calorimetry (ITC), and SAXS we were able to unravel the mechanism of inhibition of Ru4POM. Ru4POM binds to the positively-charged substrate binding region of the enzyme through electrostatic interactions, triggering the dimerization of the enzyme which consequently is inactivated. Ru4POM is the first non-peptide molecule showing a substrate-competitive mechanism of inhibition for CK2. On the basis of SAXS data, a structural model of the inactivated (CK2α)2(Ru4POM)2 complex is presented.

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Section: Resultsmentioning

confidence: 99%

“…All hybrid POMs were characterized by FTIR and ESI-MS(-) to confirm their identity. (NH 4 ) 12 [Mo 36 (NO) 4 O 108 (H 2 O) 16 ], Mo 36 POM, was prepared as reported in ( Amini et al, 2015 ).…”

Section: Methodsmentioning

confidence: 99%

Mechanism of CK2 Inhibition by a Ruthenium-Based Polyoxometalate

Fabbian

Giachin

Bellanda

et al. 2022

Front. Mol. Biosci.

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“…[20] POMs have a potential for activation of environmental oxidants such as O 2 and H 2 O 2. [21] Hydrogen peroxide is a low-cost and green oxidant that is activated by polyoxometalates. [22 ] Hydrogen peroxide is a comparatively slow oxidant at the basic medium and ambient temperature.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of a new polyoxometalate nanocluster containing Mo and V as an environmentally green catalyst for oxidative degradation of organic pollutants from aquatic environments

Naslhajian

Amini

Hosseinifard

et al. 2021

Applied Organom Chemis

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A water-insoluble Keggin-type polyoxomolybdovanadate nanocluster, (Et 4 N) 4 [VMo 12 O 40 ]ÁMeCN (1) was synthesized and crystallized in acetonitrile.The catalyst was characterized by X-ray crystallography, UV-Vis, thermogravimetric analysis (TGA), cyclic voltammetry (CV), and FT-IR techniques. Degradation of organic dyes, Amido black 10B (AB10B) and Methylene blue (MB) was investigated by 1/H 2 O 2 system at room temperature and the influence of different conditions on the decomposition of AB10B and MB dyes such as catalyst dosage, oxidant concentration, pH, radical scavengers, and reusability of 1 were studied.

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“…Sulfoxides are important intermediates in many industrial reactions owing to biological and pharmaceutical activities. Efficient and selective oxidation of sulfides to sulfoxides is an essential part of synthetic design in modern pharmaceutical processes . The application of oxido–peroxido tungsten (VI) complexes are exciting due to tungsten centers activating peroxido groups for oxidation of a variety of organic substrates …”

Section: Introductionmentioning

confidence: 99%

Oxido‐peroxido W(VI)‐histidine–MgAl‐layered double hydroxide composite as an efficient catalyst in sulfide oxidation

Nikkhoo

Amini

Sohrabi

et al. 2018

Applied Organom Chemis

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Oxido-peroxido W(VI)-histidine-MgAl-layered double hydroxide composite was prepared by using MgAl-layered double hydroxide as a host and oxidoperoxido W(VI)-histidine complex as a guest. The composite was characterized by XRD, IR, EDX,SEM and TEM techniques. This composite is tested for catalytic selective sulfoxidation reactions using hydrogen peroxide as oxidant showing good to moderate conversion along with high selectivity.

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Selective Oxidation of Sulfides Catalyzed by the Nanocluster Polyoxomolybdate (NH₄)₁₂[Mo₃₆(NO)₄O₁₀₈(H₂O)₁₆]

Abstract: The (NH 4 ) 12 [Mo 36 (NO)

Cited by 12 publications

References 33 publications

Mechanism of CK2 Inhibition by a Ruthenium-Based Polyoxometalate

Mechanism of CK2 Inhibition by a Ruthenium-Based Polyoxometalate

Synthesis and characterization of a new polyoxometalate nanocluster containing Mo and V as an environmentally green catalyst for oxidative degradation of organic pollutants from aquatic environments

Oxido‐peroxido W(VI)‐histidine–MgAl‐layered double hydroxide composite as an efficient catalyst in sulfide oxidation

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