Selective Oxidation Using In Situ-Generated Hydrogen Peroxide

Abstract

Metrics & MoreArticle Recommendations CONSPECTUS: Hydrogen peroxide (H 2 O 2 ) for industrial applications is manufactured through an indirect process that relies on the sequential reduction and reoxidation of quinone carriers. While highly effective, production is typically centralized and entails numerous energyintensive concentration steps. Furthermore, the overhydrogenation of the quinone necessitates periodic replacement, leading to incomplete atom efficiency. These factors, in addition to the presence of propriety stabilizing agents and concerns associated with their separation from product streams, have driven interest in alternative technologies for chemical upgrading. The decoupling of oxidative transformations from commercially synthesized H 2 O 2 may offer significant economic savings and a reduction in greenhouse gas emissions for several industrially relevant processes. Indeed, the production and utilization of the oxidant in situ, from the elements, would represent a positive step toward a more sustainable chemical synthesis sector, offering the potential for total atom efficiency, while avoiding the drawbacks associated with current industrial routes, which are inherently linked to commercial H 2 O 2 production. Such interest is perhaps now more pertinent than ever given the rapidly improving viability of green hydrogen production.The application of in situ-generated H 2 O 2 has been a long-standing goal in feedstock valorization, with perhaps the most significant interest placed on propylene epoxidation. Until very recently a viable in situ alternative to current industrial oxidative processes has been lacking, with prior approaches typically hindered by low rates of conversion or poor selectivity toward desired products, often resulting from competitive hydrogenation reactions. Based on over 20 years of research, which has led to the development of catalysts for the direct synthesis of H 2 O 2 that offer high synthesis rates and >99% H 2 utilization, we have recently turned our attention to a range of oxidative transformations where H 2 O 2 is generated and utilized in situ. Indeed, we have recently demonstrated that it is possible to rival state-of-the-art industrial processes through in situ H 2 O 2 synthesis, establishing the potential for significant process intensification and considerable decarbonization of the chemical synthesis sector.We have further established the potential of an in situ route to both bulk and fine chemical synthesis through a chemo-catalytic/ enzymatic one-pot approach, where H 2 O 2 is synthesized over heterogeneous surfaces and subsequently utilized by a class of unspecific peroxygenase enzymes for C−H bond functionalization. Strikingly, through careful control of the chemo-catalyst, it is possible to ensure that competitive, nonenzymatic pathways are inhibited while also avoiding the regiospecific and selectivity concerns associated with current energy-intensive industrial processes, with further cost savings associated with the operation of the chemo-enzymatic appr...

Design of poly(N-isopropylacrylamide) coated MnO2 nanoparticles for thermally regulated catalytic decomposition of H2O2

“…The catalytic decomposition of H 2 O 2 holds immense importance in laboratory chemical reactions due to its ability to serve as a controlled source of oxygen. 3,4 Common catalysts for this purpose include transition metal ions, such as manganese (Mn), iron (Fe), and palladium (Pd). 5–8 The controlled release of oxygen in chemical reactions is valuable for enhancing reaction rates and promoting specific pathways, making catalytic decomposition a key aspect of numerous chemical and biochemical processes such as oxidation reactions and the synthesis of organic compounds.…”