Selective Peptide-Mediated Enhanced Deposition of Polymer Fragrance Delivery Systems on Human Hair

Abstract

The deposition of fragrance delivery systems onto human hair from a shampoo formulation is a challenging task, as the primary function of shampoo is to cleanse the hair by removing primarily hydrophobic moieties. In this work, to tackle this challenge, phage-display-identified peptides that can bind to human hair under shampooing conditions are first identified and subsequently used to enhance the deposition of model fragrance delivery systems. These delivery systems are based on either poly(N-(2-hydroxypropyl)methacrylamide) (PHPMA) copolymers as a representative for polymeric profragrances or polyurethane/polyurea-type core-shell microcapsules as a model physical fragrance carrier. The incorporation of a hair-binding peptide enhanced the deposition of PHPMA copolymers by a factor of 3.5-5.0 depending on the extent of peptide incorporation, whereas 10 wt % surface functionalization of microcapsules with the peptide led to a 20-fold increase in their deposition. In a final experiment, treatment of the hair samples under realistic application conditions with the peptide-functionalized microcapsules resulted in an increase in fragrance release from the hair surfaces.

Hydrocolloids: Nova materials assisting encapsulation of volatile phase change materials for cryogenic energy transport and storage

“…Capsules have long enjoyed their popularity in drug carrier design, [14][15][16] fragrance retention, [17][18][19] and self-healing materials, [20][21][22] while seeking niche application frontiers in reaction scavengers, 23 lithium-ion batteries, [24][25][26][27] fuel cells, 28 carbon capture, 29 and thermal energy storage. [30][31] In most cases, the active ingredients are non-volatile liquids or even solids at room temperature, 32 which extenuates the leakage problem and endorses a diverse range of synthesis routes.…”

A novel photothermo-responsive nanocarrier for the controlled release of low-volatile fragrances

“…The surface deposition of fragranced products is an important parameter that determines the long-lastingness of fragrance perception. [48][49][50] We thus examined the adhesion of fragranceloaded nanoparticles to the silk fabric and their washing durability. Fig.…”

Shape Dependent Colloidal Deposition and Detachment

“…For example, contact adhesion can be increased by chemical surface modification, including species adsorbed from solution [7] as well as specific interactions mediated by peptides. [12] In an example of another design constraint, composite capsule shells can be carefully designed to retain fragrant oils until capsules are ruptured for fragrance release. [13] Such core-shell capsules have been shown to buckle into nonspherical shapes, which has been shown to produce enhanced deposition on hair compared to spherical capsules.…”

“…Fragrance capsules are highly engineered to control their stability within formulations, deposition on substrates, and release of fragrant contents. For example, contact adhesion can be increased by chemical surface modification, including species adsorbed from solution as well as specific interactions mediated by peptides . In an example of another design constraint, composite capsule shells can be carefully designed to retain fragrant oils until capsules are ruptured for fragrance release .…”