2001
DOI: 10.1046/j.1523-1747.2001.01345.x
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Selective Pick-Up of Increased Iron by Deferoxamine-Coupled Cellulose Abrogates the Iron-Driven Induction of Matrix-Degrading Metalloproteinase 1 and Lipid Peroxidation in Human Dermal Fibroblasts In Vitro: A New Dressing Concept

Abstract: Using atomic absorption spectrum analysis, we found iron levels in exudates from chronic wounds to be significantly increased (3.71 +/- 1.56 micromol per g protein) compared to wound fluids from acute wounds derived from blister fluids (1.15 +/- 0.62 micromol per g protein, p < 0.02), drainage fluids of acute wounds (0.87 +/- 0.34 micromol per g protein, p < 0.002), and pooled human plasma of 50 volunteers (0.42 micromol per g protein). Increased free iron and an increase in reactive oxygen species released fr… Show more

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Cited by 102 publications
(95 citation statements)
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“…4-9,13,14 Wenk et al 7 and Yeoh-Ellerton 13 found increased iron levels in exudates from chronic leg ulcers as compared to acute wounds. They also observed significant concentrations of metabolites from oxidative stress.…”
Section: Iron Dependent Inflammation In Cvdmentioning
confidence: 98%
“…4-9,13,14 Wenk et al 7 and Yeoh-Ellerton 13 found increased iron levels in exudates from chronic leg ulcers as compared to acute wounds. They also observed significant concentrations of metabolites from oxidative stress.…”
Section: Iron Dependent Inflammation In Cvdmentioning
confidence: 98%
“…Dysregulated ROS generation may induce several pathological defects, such as damage to endothelial cells, prolonged recruitment of leukocytes to the ulcer site, and delayed keratinocyte migration and reepithelialization [ 34 ] . Apart from pathologically elevated ROS levels, an increase in free iron in macrophages and in the extracellular matrix at the wound site is also thought to lead to prolonged infl ammation, increased connective tissue degradation, and resultant lipid peroxidation in chronic ulcers due to the Fenton reaction [ 35 ] . In addition, the antioxidative defense system has been shown to be disturbed in chronic wound patients.…”
Section: Inflammation and Oxidative Stress In Chronic Woundsmentioning
confidence: 99%
“…Exuberant inflammation interferes with all subsequent wound healing processes and manifests itself as inadequate mesenchymal cell chemotaxis and proliferation, angiogenesis, epithelization, wound contraction, collagen synthesis and remodeling. There is increasing evidence that the persisting infiltration of neutrophils and macrophages plays a major role in the generation of a protease rich and prooxidant hostile microenvironment (21)(22)(23). Recent experimental and several comprehensive clinical studies demonstrated that the proteolytic activity of matrix metalloproteinases and serine proteinases is significantly upregulated in the exudate of chronic wounds (24)(25)(26)(27), thus contributing to the degradation of extracellular matrix molecules (24,25), growth factors and their receptors (28)(29)(30).…”
Section: Mechanisms Of Impaired Healingmentioning
confidence: 99%