Selective protective effects of nitric oxide inhalation on allergen‐induced acute airway reactions in the pig

Abstract

These findings indicate that NO inhalation improves ventilation/perfusion matching and causes some bronchodilatation during the allergen-induced acute airway reaction, whereas histamine release is not affected. Moreover, NO inhalation enhanced the clearance of extravasated protein in the airways, possibly through increased bronchial blood flow. Even though some protective effects were seen, this study does not support a therapeutic role for exogenous NO in acute allergic reactions.

A Novel ELR-CXC Chemokine Antagonist Reduces Intestinal Ischemia Reperfusion-Induced Mortality, and Local and Remote Organ Injury

“…We also saw a very modest hepatic neutrophilia in the I/R injury animals, but G31P had no significant effect on this response. While we found no airway neutrophilia in our I/R injury animals, we did find evidence of increased vascular leakage, as determined using BAL fluid protein levels as a surrogate marker [28]. Airway protein levels and RBC numbers were increased at the 5 h time-point (Fig.…”

Pulsating flow and mass transfer in an asymmetric system of bifurcations

“…Interest has mainly been in deposition and targeted delivery of aerosols and gas [6,28,29]. For instance, it has been shown that NO has caused bronchodilation and improved ventilation [30,31]. It should be pointed out that in general there is a Reynolds number difference between the airway and the arterial system.…”