Selective Recognition of Kanamycin via Molecularly Imprinted Nanosensor

Abstract

K anamycin (KAN) indicates two forms of aminoglycoside, a crystalline monosulfate monohydrate, and salt with a higher sulfate content [1]. Due to their low cost of production, these compounds are widely used in the treatment of narrow therapeutic indexes, especially in veterinary medicine [2][3][4][5]. Despite its widespread use in the form of injections and capsules as a second-line antibiotic, there is increasing concern about KAN overuse, as well as overconsumption of KAN-containing animal-derived food because it could induce accumulation in an animal body and transferred into the food chain [3,5,6]. Residues of kanamycin were found to imperil people's health, causing severe side effects such as hearing loss, kidney damage, and allergic shock [3,7]. In this sense, there are effective strategies accessible for kanamycin detection in various mediums. Until now, numerous analytical methods have been applied for the KAN detection such as spectrophotometry [3,6], cantilever array sensor [5], high performance liquid chromatography (HPLC) [8, 9], solid-phase extraction (SPE) [9],

Molecularly Imprinted Polymer-Based Sensors for SARS-CoV-2: Where Are We Now?

“…Nevertheless, the synthesis of molecularly imprinted polymers (MIPs) was boosted by Wulff and Mosbach later in the 1970s [ 22 , 23 ]. Since then, a broad spectrum of analytes including low-molecular-weight molecules, such as pharmaceuticals, sugars, toxins, narcotic drugs, pesticides, and biomacromolecules such as proteins, nucleic acids, bacteria, and viruses have been described [ 20 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 ].…”