Selective recognition of the amyloid marker single thioflavin T using DNA origami-based gold nanobipyramid nanoantennas

Abstract

The development of effective methods for the detection of indication of protein misfolding is highly beneficial for early stage medical diagnostics and prevention of many neurodegenerative diseases. Self-assembled plasmonic nanoantennas...

DNA-Assembled SERS-Active Multimeric Nanoparticle Structures

“…144−146 A gold nanopyramid nanoparticle dimer structure was assembled for sensitive detection of thioflavin T (ThT), a known marker for amyloid formation. 147 In another study, gold nanocubes (edge length of 50 nm) were assembled into plasmonic gap structures with exquisite geometrical configurations and precise nanogaps. Using ROX-modified oligonucleotides, a colossal enhancement of Raman signatures was observed, leading to the Raman reporter's single-molecule detection.…”

“…Rectangular origami structures were elegantly used to assemble gold nanostar dimer structures, which show more than 10 10 -fold enhancement of a Raman reporter (Texas red) . Later, gold nanostars were modified into gold–silver hybrid structures and used for sensitive pyocyanin, dopamine, and thrombin detection. − A gold nanopyramid nanoparticle dimer structure was assembled for sensitive detection of thioflavin T (ThT), a known marker for amyloid formation . In another study, gold nanocubes (edge length of 50 nm) were assembled into plasmonic gap structures with exquisite geometrical configurations and precise nanogaps.…”

Quantifying Shape Transition in Anisotropic Plasmonic Nanoparticles through Geometric Inversion. Application to Gold Bipyramids

“…Anisotropic plasmonic nanoparticles stand out in finely tuning their localized surface plasmon resonance (LSPR) and creating strong electric fields by precisely adjusting the nanoparticle aspect ratio, particularly the length-to-width ratio, surpassing the impact of size variations in isotropic nanoparticles. − While gold (Au) nanorods remain the most versatile and consolidated type of anisotropic nanoparticles, − Au bipyramids (AuBPs) become an optimal alternative due to a superior number of physical properties and applications across plasmon resonance, ,− electric field enhancement, ,,− thermal stability, coupling processes, − sensing capabilities, − photocatalysis, , acoustic characteristics, and nonlinear optics. − Tuning the shape and size of plasmonic nanoparticles under optical excitation can initiate/elicit chemical transformations near/on their surfaces . These processes leverage the enhanced localized electric fields associated with plasmon excitation (by photothermal effect and/or hot carriers generation), presenting possibilities to drive reduction or oxidation reactions. − Also, AuBPs are particularly appealing for bottom-up fabrication, offering a wide range of structural diversity in two-dimensional (2D) systems and three-dimensional (3D) supercrystals .…”

“…Anisotropic plasmonic nanoparticles stand out in finely tuning their localized surface plasmon resonance (LSPR) and creating strong electric fields by precisely adjusting the nanoparticle aspect ratio, particularly the length-to-width ratio, surpassing the impact of size variations in isotropic nanoparticles. 1 − 3 While gold (Au) nanorods remain the most versatile and consolidated type of anisotropic nanoparticles, 4 − 7 Au bipyramids (AuBPs) become an optimal alternative due to a superior number of physical properties and applications across plasmon resonance, 4 , 8 − 10 electric field enhancement, 4 , 9 , 11 − 14 thermal stability, 15 coupling processes, 15 − 22 sensing capabilities, 23 − 31 photocatalysis, 32 , 33 acoustic characteristics, 34 and nonlinear optics. 35 − 37 Tuning the shape and size of plasmonic nanoparticles under optical excitation can initiate/elicit chemical transformations near/on their surfaces.…”

Immobilising an acid-cleavable dimeric phthalocyanine on gold nanobipyramids for intracellular pH detection and photodynamic elimination of cancer cells

“…10 Despite the superior plasmonic features, owing to the low number purities (<60%) of colloidal AuBP samples prepared by common seed-mediated growth methods, 11 only a few AuBP-based SERS bioprobes have been reported so far. 12 The dimeric phthalocyanine also serves as an acid-activatable photosensitiser, which can photodynamically eliminate cancer cells upon light irradiation, endowing an additional therapeutic function to this nanocomposite (Fig. 1).…”