Selective recruitment of CCR6-expressing cells by increased production of MIP-3α in rheumatoid arthritis

Matsui, Toshimichi; Akahoshi, Tohru; Namai, Rie; Hashimoto, Akihiko; Kurihara, Yoshitaka; Rana, Mitra S.; Nishimura, Akinobu; Endo, Hirahito; Kitasato, Hidero; Kawai, Shinichi; Takagishi, Kenji; Kondo, Hirobumi

doi:10.1046/j.1365-2249.2001.01542.x

Cited by 125 publications

(108 citation statements)

References 33 publications

Supporting

Mentioning

105

Contrasting

Unclassified

Order By: Relevance

“…32 Infiltrating mononuclear cells and synovial fibroblasts produce MIP3a in rheumatoid arthritis patients in response to IL-1 and TNFa. 33 MIP3a then recruits leukocytes such as memory T cells, naïve B cells and dendritic cells. 33 RANTES, a pro-inflammatory chemokine, is also stimulated by IL-1 and TNFa, produced by fibroblasts, and involved in trafficking leukocytes subsets into inflamed tissues.…”

Section: Discussionmentioning

confidence: 99%

“…33 MIP3a then recruits leukocytes such as memory T cells, naïve B cells and dendritic cells. 33 RANTES, a pro-inflammatory chemokine, is also stimulated by IL-1 and TNFa, produced by fibroblasts, and involved in trafficking leukocytes subsets into inflamed tissues. 34 We found significantly increased numbers in distal forelimb loose connective tissues in LRNF rats, bilaterally, in week 6.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Serum and tissue cytokines and chemokines increase with repetitive upper extremity tasks

Barbe

Elliott

Abdelmagid

et al. 2008

Journal Orthopaedic Research

112

View full text Add to dashboard Cite

We investigated inflammation in rats performing a low repetition, negligible force (LRNF) or high repetition, negligible force (HRNF) task of reaching and retrieving food pellets at target rates of two or four reaches/min for 2 h/day, for 6-8 weeks. Serum was assayed for 11 cytokines and chemokines; forelimb tissues for four cytokines. Macrophages were counted in forelimb tissues of LRNF rats to add to results from our previous studies of HRNF rats. In HRNF rats, serum IL-1a, IL-1b, TNFa, MIP2, MIP3a, and RANTES were elevated in weeks 6 and 8. In contrast, only MIP2 and MIP3a increased in serum of LRNF rats. In 8 week HRNF reach limb tissues, IL-1a, IL-1b, TNFa, and IL-10 increased in distal bones, IL-1a and -b in muscles, and TNFa in tendons. Only IL-10 increased in LRNF reach limb muscles in week 8. Serum IL-1a and MIP2 correlated with macrophages in LRNF loose connective tissues, serum MIP3a and MIP2 correlated negatively with grip strength, while serum TNFa, MIP3a, and MIP2 correlated positively with total number of reaches. Thus, several tissue and circulating cytokines/chemokines increase in an exposure dependent manner following short-term performance of repetitive reaching tasks and correlate with macrophage infiltration and decreasing grip strength. Keywords: cytokines; chemokines; macrophages; repetitive motion injury; WMSD Repetitive motion injuries (RMI) of the wrist and hand are painful, potentially disabling, and costly. Recent work suggests that RMIs induce injury in several tissue types in animal models, 1-6 as well as an early inflammatory response at the tissue level. 2,3,[7][8][9] Increases in four circulating inflammatory mediators, C-reactive protein, interleukin 1 beta (IL-1b), IL-6, and tumor necrosis factor alpha (TNFa) have also been shown to increase in patients with upper extremity overuse disorders. 10 The factors triggering underlying pathophysiological responses are still under investigation, which impedes progress toward their primary and secondary prevention.Using a rat model, we have reported that repetitive reaching causes injury and wide-spread increases in macrophage influx into musculotendinous tissues and peripheral nerves, extraneural fibrosis, decreased nerve conduction, and decreased grip strength. [2][3][4]7,9 The macrophage response is associated with increased inflammatory cytokines in the median nerve, 9 and increased serum IL-1a following HRNF task performance. 2 A variety of inflammatory mediators including cytokines and chemokines are released by injured cells and infiltrating macrophages. 9,11 Although serum cytokine and chemokine response patterns to exercise of varying intensities 12-15 and multiple organ trauma and fractures have been studied, [16][17][18] exposure to more chronic, lower levels of injury are not yet well characterized.Here, we examine several cytokines and chemokines in forelimb musculoskeletal tissues and serum to identify their response profiles, as well as potential cellular sources, after the performance of a voluntary repetitive ...

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Serum and tissue cytokines and chemokines increase with repetitive upper extremity tasks

Barbe

Elliott

Abdelmagid

et al. 2008

Journal Orthopaedic Research

112

View full text Add to dashboard Cite

show abstract

“…Other chemokine receptors may also be involved in RA. CCR6, a receptor for MIP-3␣/CCL20, was detected on infiltrating white blood cells in the RA ST (69). XCR1, the lymphotactin/XCL1 receptor, was immunolocalized to ST lymphocytes, macrophages, and fibroblasts.…”

Section: Chemokine Receptorsmentioning

confidence: 97%

“…In the ST, mainly infiltrating macrophages and ST lining cells expressed MIP-3␣/CCL20. RA ST fibroblasts produced this chemokine in response to cytokines, including TNF␣, IL-1, IL-17, or IL-18 (69)(70)(71). MIP-3␣ is potently chemotactic for monocytes (70).…”

Section: Chemokinesmentioning

confidence: 99%

Chemokines and their receptors in rheumatoid arthritis: Future targets?

Koch¹

2005

Arthritis & Rheumatism

225

208

View full text Add to dashboard Cite

“…MIP-3α is a CC chemokine which attracts memory T-lymphocytes and dendritic cells expressing the CCR6 receptor [19,20,21]. The expression of MIP-3α is up-regulated in psoriatic skin [22], atopic dermatitis [23] and rheumatoid arthritis [24] and MIP-3α is involved in the amplification of local inflammatory responses in the liver [25]. Fractalkine is the single member of the CX3C family of chemokines.…”

mentioning

confidence: 99%

IL-1β and IFN-γ induce the expression of diverse chemokines and IL-15 in human and rat pancreatic islet cells, and in islets from pre-diabetic NOD mice

et al. 2003

View full text Add to dashboard Cite

Aims/hypothesis. Cytokines and chemokines are important mediators of immune responses due to their ability to recruit and activate leukocytes. Using microarray analysis we observed that rat beta cells exposed to IL-1β and IFN-γ have increased mRNA levels of chemokines and IL-15. The aim of this study was to characterize the expression of IP-10, MIP-3α, fractalkine and IL-15 in rat beta cells, human pancreatic islets, and in islets isolated from NOD mice, both during the pre-diabetic period and following islet transplantation. Methods. FACS-purified rat beta cells and human islets were cultured with IL-1β, IFN-γ and/or TNF-α. Islets were isolated from NOD or BALB/c mice at different ages. For syngeneic islet transplantation, 2-or 3-week-old NOD islets were grafted under the kidney capsule of spontaneously diabetic NOD recipients. Chemokine and IL-15 mRNA expression and protein release were evaluated, respectively, by RT-PCR and ELISA.Results. Human islets and rat beta cells express IP-10, MIP-3α, fractalkine and IL-15 mRNAs upon exposure to cytokines. The expression of IL-15, IP-10 and fractalkine is regulated by IFN-γ, while the expression of MIP-3α is IL-1β-dependent. Moreover, cytokines induced IL-15, IP-10, Mig, I-TAC and MIP-3α protein accumulation in culture medium from human islets. In vivo, there was an age-related increase in IL-15, IP-10 and MIP-3α expression in islets isolated from NOD mice. Following syngeneic islet transplantation, increased expression of IL-1β, IFN-γ, fractalkine, IP-10, MCP-1 and MIP-3α mRNAs were observed in the grafts. Conclusion/interpretation. Cytokine-exposed islets or beta cells express chemokines and IL-15. This could contribute to the recruitment and activation of mononuclear cells and development of insulitis in early Type 1 diabetes and during graft destruction. [Diabetologia (2003) 46:255-266] Keywords Type 1 diabetes mellitus, chemokines, IL-15, NOD mice, beta cells, interferon-γ, interleukin-1β, pancreatic islets, islet transplantation, insulitis.

show abstract

Selective recruitment of CCR6-expressing cells by increased production of MIP-3α in rheumatoid arthritis

Cited by 125 publications

References 33 publications

Serum and tissue cytokines and chemokines increase with repetitive upper extremity tasks

Serum and tissue cytokines and chemokines increase with repetitive upper extremity tasks

Chemokines and their receptors in rheumatoid arthritis: Future targets?

IL-1β and IFN-γ induce the expression of diverse chemokines and IL-15 in human and rat pancreatic islet cells, and in islets from pre-diabetic NOD mice

Contact Info

Product

Resources

About