Selective reduction of carboxylic acids into alcohols using sodium borohydride and iodine

N-Thiophenylethyl-2,2-dichloro-1-cyclopropanecarboxamides: modification of the amide part of carpropamid and examination of fungicidal activity

“…The last transformation proceeded well using a mild reducing reagent, isobutyl aluminum hydride, after the published protocol. 19) A similar method was used to prepare 2-(2-chlorothiazol-5yl)ethylamine.…”

Synthesis, reactivity and conformational stability of an l-phenylalanine derived oxadiazinanone

“…L L-Phenylalanine 4 was reduced to L L-phenylalaninol by reduction with sodium borohydride and iodine using a method developed by Kanth and Periasamy 11 and later optimized for a-amino acids by Meyers et al (Scheme 1). 12 The resultant b-aminoalcohol was reductively alkylated 13 with acetone and sodium borohydride to afford the N-isopropyl derivative 5, which was converted to its corresponding b-hydrazino-alcohol 6.…”

Reduction of 2,3-Seco-28-oxo-19β,28-epoxy-18α-olean-2,3-dicarboxylic acid and its cyclic anhydride

“…This was used earlier for selective reduction of different carboxylic acids [12]. The optimum conditions for this reaction were a three-fold excess of I 2 and heating at 40°C for 6 h. This practically completely converted starting 1 to the diol 6, which was isolated in 73% yield.…”

“…The optimum conditions for this reaction were a three-fold excess of I 2 and heating at 40°C for 6 h. This practically completely converted starting 1 to the diol 6, which was isolated in 73% yield. Carrying out the reaction at room temperature gave a low conversion of the starting compound that was probably due to the formation of insoluble intermediates [12]. Increasing the reaction time produced in the reaction mixture the product of further reduction, tetraol 3.…”