Selective Release of Multiple DNA Oligonucleotides from Gold Nanorods

Wijaya, Andy; Schaffer, Stefan Benjamin; Pallares, Ivan G.; Hamad‐Schifferli, Kimberly

doi:10.1021/nn800702n

Cited by 392 publications

(415 citation statements)

References 34 publications

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“…Modulation of the irradiance allows continuous control of heat production and consequently of drug release from thermosensitive devices. For the devices studied in the present report, we used hollow gold nanoshells (AuNSs) because they are less likely to deform than gold nanorods (8) and have previously been used for other biomedical applications (23). Synthetic routes toward AuNSs have been well established, and their absorbance maxima can be tuned anywhere within the NIR window to match the wavelength of the excitation source (23,24).…”

Section: Significancementioning

confidence: 99%

“…They have been realized as microchips (5), liposomes (6), microparticles (7), nanoparticles (8), and macroscale polymers (9) that release loaded drugs when the stimulus is applied. In principle, these materials enable control over the dose and timing of drug release and therefore can be used to achieve complex drug release regimens not possible with conventional passive sustained-release systems.…”

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confidence: 99%

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Near-infrared–actuated devices for remotely controlled drug delivery

Timko

Arruebo

Shankarappa

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

182

175

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A reservoir that could be remotely triggered to release a drug would enable the patient or physician to achieve on-demand, reproducible, repeated, and tunable dosing. Such a device would allow precise adjustment of dosage to desired effect, with a consequent minimization of toxicity, and could obviate repeated drug administrations or device implantations, enhancing patient compliance. It should exhibit low off-state leakage to minimize basal effects, and tunable on-state release profiles that could be adjusted from pulsatile to sustained in real time. Despite the clear clinical need for a device that meets these criteria, none has been reported to date to our knowledge. To address this deficiency, we developed an implantable reservoir capped by a nanocomposite membrane whose permeability was modulated by irradiation with a near-infrared laser. Irradiated devices could exhibit sustained onstate drug release for at least 3 h, and could reproducibly deliver short pulses over at least 10 cycles, with an on/off ratio of 30. Devices containing aspart, a fast-acting insulin analog, could achieve glycemic control after s.c. implantation in diabetic rats, with reproducible dosing controlled by the intensity and timing of irradiation over a 2-wk period. These devices can be loaded with a wide range of drug types, and therefore represent a platform technology that might be used to address a wide variety of clinical indications.gold | nanoshell | poly(n-isopropylacrylamide) | ethylcellulose | diabetes

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Section: Significancementioning

confidence: 99%

mentioning

confidence: 99%

Near-infrared–actuated devices for remotely controlled drug delivery

Timko

Arruebo

Shankarappa

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

182

175

View full text Add to dashboard Cite

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“…During the past few years, GNPs have demonstrated applicability in imaging, 1 sensing, 2Ϫ4 drug and gene delivery, 5,6 and in photothermal therapy. 7 Most applications take advantage of the unique optical properties of GNPs supported by their localized surface plasmon resonance (LSPR).…”

mentioning

confidence: 99%

Microglial Response to Gold Nanoparticles

et al. 2010

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“…Among the stimuli-sensitive NPs are the light-sensitive ones. For example, light-stimulated remote release of nucleic acid has been attempted by utilizing the tunable optical properties and moderating the Au-S bond strength of various gold nanomaterials [532,533] . For example, the temporally and spatially controlled delivery of siRNA using NIR-sensitive gold nanoshell-siRNA conjugates was explored [534] .…”

Section: Perspectives: Multimodal Theranostic Npsmentioning

confidence: 99%

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Trequesser¹,

Seznec²,

Delville

2013

Nanotechnology Reviews

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Abstract:The successful development of nanomaterials illustrates the considerable interest in the development of new molecular probes for medical diagnosis and imaging. Substantial progress was made in the synthesis protocol and characterization of these materials, whereas toxicological issues are sometimes incomplete. Nanoparticlebased contrast agents (CAs) tend to become efficient tools for enhancing medical diagnostics and surgery for a wide range of imaging modalities. The multimodal nanoparticles (NPs) are much more efficient than the conventional molecular-scale CAs. They provide new abilities for in vivo detection and enhanced targeting efficiencies through longer circulation times, designed clearance pathways, and multiple binding capacities. Properly protected, they can safely be used for the fabrication of various functional systems with targeting properties, reduced toxicity, and proper removal from the body. This review mainly describes the advances in the development of mono-to multimodal NPs and their in vitro and in vivo relevant biomedical applications ranging from imaging and tracking to cancer treatment. Besides the specific applications for classical imaging (magnetic resonance imaging, positron emission tomography, computed tomography, ultrasound, and photoacoustic imaging), the less common imaging techniques such as terahertz molecular imaging (THMI) or ion beam analysis (IBA) are mentioned. The perspectives on the multimodal theranostic NPs and their potential for clinical advances are also mentioned.

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Selective Release of Multiple DNA Oligonucleotides from Gold Nanorods

Cited by 392 publications

References 34 publications

Near-infrared–actuated devices for remotely controlled drug delivery

Near-infrared–actuated devices for remotely controlled drug delivery

Microglial Response to Gold Nanoparticles

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

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