Selective Removal of Silver Impurity from Oxaliplatin by Sorption on Functionalized Polymer

Abstract

This report relates to synthesis of functionalized polymeric adsorbents for selective removal of silver ion in the presence of platinum (II) from crude oxaliplatin, thus providing an effective method for its purification with a desired impurity profile for silver. Two chelating ligands, thiourea and thiosemicarbazide, were grafted on styrene back-bone cross-linked with 2 % divinyl benzene (DVB) and tested by batch adsorption studies for the uptake of silver and platinum. The maximum sorption capacity values for both the adsorbents for Ag + were 101.58 and 67.75 (mg/g), respectively, with an exceptionally high value of separation factor (α = 1155 and 231) over platinum. The experimental sorption data were fitted well with the Langmuir model. Desorption of silver from the polymer can be achieved by using 0.3M Na 2 S solution for regeneration.

Experimental and DFT studies for selective separation of Sb(iii) and Sb(v) from mixtures with Zr(iv)/Co(ii) using thiourea grafted polystyrene adsorbent

“…average pore size and pore volume of TPS-DVB were measured in co-ordinance with our 3 previous reports on the similar adsorbents 30. 31 4 4.1.…”

“…The synthesis (Scheme 1) and characterization of thiourea graed on poly(styrene-DVB) copolymer (TPS-DVB) was performed according to previous reports. 30,31 3.1.2. Batch adsorption studies.…”

“…7,24 In addition, thiourea immobilized as thiol and isothiouronium resins have also been reported for selective removal of heavier transition metals. [25][26][27][28][29][30] The current work reports the use of thiourea based polystyrene adsorbent (TPS-DVB) for selective and optimum adsorption of antimony(III and V) ions from mixtures with cobalt and zirconium. The DFT studies were also performed for the complexation of the metal ion with the functionalized adsorbent providing structural, energetics and electronic information.…”

“…A 18 radiofrequency (RF) generator with 1400 W power and 27.12 MHz frequency was used along 19 with charge-coupled device (CCD). 30 The 21 samples were injected into the plasma by maintaining the pump speed of 30 rpm.…”

Silver recovery from greywater: Role of competing cations and regeneration

“…El -Ghaffar et al (2009) [26] prepared resin derived from condensation of 3-amino-1,2,4, triazole-5-thiol and glutaraldehyde which recovered 3.6 mmoles of silver per gram of its dry weight. A thiourea-modified adsorbent having styrene backbone selectively removed silver in the presence of platinum with an uptake capacity of 101.58 mg/g and a high separation factor of 1155 [27]. Quang et al (2013) [28] prepared silica beads by grafting thiol functional group on silica gel which recovered as well as reduced silver with an uptake capacity of 75.8 mg/g.…”