2012
DOI: 10.1074/jbc.m111.300194
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Selective Roles for cAMP Response Element-binding Protein Binding Protein and p300 Protein as Coregulators for Androgen-regulated Gene Expression in Advanced Prostate Cancer Cells

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Cited by 104 publications
(72 citation statements)
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“…We hypothesized that this dependence on coactivator proteins for the functional output of AR activation may present a potential point of intervention in CRPC. The highly homologous histone acetyltransferases CBP [cAMP response element binding protein (CREB) binding protein] and p300 are known coactivators of AR and have been implicated in enhancing the response to androgen (16)(17)(18). Consistent with this, CBP/p300 has been proposed to play an oncogenic role in prostate cancer, and upregulation of both proteins has been observed in tumors (19)(20)(21).…”
Section: Introductionsupporting
confidence: 48%
“…We hypothesized that this dependence on coactivator proteins for the functional output of AR activation may present a potential point of intervention in CRPC. The highly homologous histone acetyltransferases CBP [cAMP response element binding protein (CREB) binding protein] and p300 are known coactivators of AR and have been implicated in enhancing the response to androgen (16)(17)(18). Consistent with this, CBP/p300 has been proposed to play an oncogenic role in prostate cancer, and upregulation of both proteins has been observed in tumors (19)(20)(21).…”
Section: Introductionsupporting
confidence: 48%
“…It should also be realized that the step at which a factor binds is not always equivalent to when that factor exerts its biological effect. For example, the number of genomic binding sites for GRs is ϳ10-fold greater than the number of induced genes (59,60), there is no temporal correlation between GR binding to enhancer regions and the transcriptional response (61), p300 is recruited to the androgen-responsive elements of the TMPRSS2 and FKBP5 genes but is required for androgen induction of only TMPRSS2 (62), and paused RNA polymerase II is bound well before it is active in transcriptional elongation.…”
Section: Discussionmentioning
confidence: 99%
“…The number of binding sites in the genome for the glucocorticoid receptor (GR) 4 is ϳ10-fold greater than the number of induced genes (14,15). p300 is recruited by added androgen to the androgen-responsive elements of the TMPRSS2 and FKBP5 genes but is required for androgen induction of only the former gene (13). RNA polymerase II is frequently found bound to pausing sites at about 50 bp downstream from the start of transcription of the induced gene but is not engaged in elongation until a later time (16 -18).…”
mentioning
confidence: 99%