Selective Screening of Biological Thiols by Means of an Unreported Magenta Interaction and Evaluation Using Smartphones

Ortega-Higueruelo, Francisco J.; Langa, Fernando

doi:10.1021/acsomega.8b00783

Cited by 2 publications

References 38 publications

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Determination of N-acetyl-L-cysteine and glutathione by the colorimetric method with the use of a smartphone as a detector

Martinović Bevanda,

Arapović,

Vasilj

et al. 2024

Chem. Pap.

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The possibility of determining N-acetyl-L-cysteine or Glutathione based on the reaction with Cu(II)neocuproine complex according to a simple procedure and using a spectrophotometer or a smartphone as detectors is described. The analytical applicability of the methods was tested and the excellent characteristics of the smartphone as a detector in the analysis of pharmaceuticals were observed. The prepared reaction solutions were yellow and their absorbance was measured at a wavelength of 450 nm. Also, due to the yellow color of the solution, the intensity of the blue RGB channel decreased with increasing thiol concentration. The proposed procedures allow the determination of both thiols in the linear dynamic range from 3.0×10 − 6 to 2.0×10 − 4 mol L -1 for a spectrophotometer as a detector, or from 6.0×10 − 6 to 2.0×10 − 4 mol L -1 for a smartphone as a detector. The obtained results indicate the usefulness of the CUPRAC method in the analysis of thiols, but also represent a smartphone as a comparable detector with a UV-Vis spectrophotometer.

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Determination of N-acetyl-L-cysteine and glutathione by the colorimetric method with the use of a smartphone as a detector

Martinović Bevanda,

Arapović,

Vasilj

et al. 2024

Chem. Pap.

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show abstract

Determination of N-acetyl-L-Cysteine and Glutathione by the colorimetric method with the use of a smartphone as a detector

Bevanda,

Arapović,

Vasilj

et al. 2023

Preprint

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The possibility of determining N-acetyl-L-cysteine or Glutathione based on the reaction with Cu(II)-neocuproine complex according to a simple procedure and using a spectrophotometer or a smartphone as detectors is described. The analytical applicability of the methods was tested and the excellent characteristics of the smartphone as a detector in the analysis of pharmaceuticals were observed. The prepared reaction solutions were yellow and their absorbance was measured at a wavelength of 450 nm. Also, due to the yellow color of the solution, the intensity of the blue RGB channel decreased with increasing thiol concentration. The proposed procedures allow the determination of both thiols in the linear dynamic range from 3.0×10− 6 to 2.0×10− 4 mol L-1 for a spectrophotometer as a detector, or from 6.0×10− 6 to 2.0×10− 4 mol L-1 for a smartphone as a detector. The obtained results indicate the usefulness of the CUPRAC method in the analysis of thiols, but also represent a smartphone as a comparable detector with a UV-Vis spectrophotometer.

show abstract

Selective Screening of Biological Thiols by Means of an Unreported Magenta Interaction and Evaluation Using Smartphones

Cited by 2 publications

References 38 publications

Determination of N-acetyl-L-cysteine and glutathione by the colorimetric method with the use of a smartphone as a detector

Determination of N-acetyl-L-cysteine and glutathione by the colorimetric method with the use of a smartphone as a detector

Determination of N-acetyl-L-Cysteine and Glutathione by the colorimetric method with the use of a smartphone as a detector

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