Selective separation of no carrier added Sc-47 from reactor irradiated Ca using zirconium vanadate gel for nuclear medical applications

Abstract

Various concentrations of HCl or HNO3 on Zirconium Vanadate (ZrV) gel as an ion exchanger were studied by batch technique to determine the Kd values of 47 Ca(II) and 47 Sc(III) ions. A small chromatographic column packed with ZrV gel for 47 Sc(III) separation based on a high elution yield with high purity from the point of view chemical, radiochemical and radionuclidic. The maximum elution yield of 47 Sc (88 ± 2.2%) was obtained using 60% acetone-0.2 M HCl as an eluent. The 47 Sc was separated with acceptable radionuclidic purity (> 99.98±0.001%) and radiochemical purity (99.9±0.09%), in addition to a very low concentrations of Ca +2 ( 0.05 ppm) which is lower than the permissible level (10 ppm) for medical applications, particularly for the labelling of pharmaceutical compounds.

Scandium Radioisotopes—Toward New Targets and Imaging Modalities

“…The concentrations of metal impurities were at very low levels, differing favorably from their content in other separation procedures. Gizawy et al presented an interesting study regarding the use of zirconium vanadate gel (ZrV) for the effective separation of scandium-47 from the irradiated natural calcium target [54]. This inorganic sorbent was synthesized from zirconium oxychloride and sodium vanadate.…”

“…Gizawy et al presented an interesting study regarding the use of zirconium vanadate gel (ZrV) for the effective separation of scandium-47 from the irradiated natural calcium target [54]. This inorganic sorbent was synthesized from zirconium oxychloride and sodium vanadate.…”